Results 11 to 20 of about 9,967 (136)
A Crosstalk between the Receptor Tyrosine Kinase-Like Orphan Receptors ROR1/2 and S1P Signaling Pathways in Lung Cancer. [PDF]
Asian Pac J Cancer PrevAvailability of multimodal treatment strategies, including targeted therapies and immunotherapies, have improved the survival of non-small cell lung carcinoma (NSCLC). However, some patients still progress or respond poorly due to inherent resistance, acquired resistance, or lack of druggable driver mutations. Sphingosine-1-phosphate (S1P) and receptor
Nema R, Pandey R, Kumar A.
europepmc +3 more sources
ROR2 (receptor tyrosine kinase-like orphan receptor 2) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on ROR2 (receptor tyrosine kinase-like orphan receptor 2), with data on DNA, on the protein encoded, and where the gene is implicated.
Wright, TM, Rathmell, WK
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ROR1 and ROR2 in Human Malignancies: Potentials for Targeted Therapy
Frontiers in Oncology, 2012 Targeted therapies require cellular protein expression that meets specific requirements that will maximize effectiveness, minimize off-target toxicities, and provide an opportunity for a therapeutic effect.
Guilly eRebagay +4 more
doaj +1 more source
A Wnt/Calcium Signaling Cascade Regulates Neuronal Excitability and Trafficking of NMDARs
Cell Reports, 2017 Wnt signaling controls multiple biological process, particularly the embryonic development of metazoans. Sustained expression of Wnt signaling components in the mature mammalian CNS and their apparent deregulation in certain neuropathologies suggest that
Andrea McQuate +2 more
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The Role of Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1) in Cancer Stem Cell Signaling. [PDF]
Int J Mol SciReceptor tyrosine kinase-like orphan receptor 1 (ROR1) is a key regulator of cancer stem cell (CSC) biology and signaling. In CSCs, ROR1 acts as a receptor or co-receptor, interacting with non-canonical WNT ligands, and forming complexes with proteins like CD19 and HER2, to activate diverse downstream signaling pathways. ROR1 signaling in CSCs promotes
Jung MS +4 more
europepmc +3 more sources
International Journal of Hematology-Oncology and Stem Cell Research, 2023 Background: The transmembrane receptor tyrosine kinase-like orphan receptor 1 (ROR1) has acted on the causation and sustentation of mature B cell lymphomagenesis for chronic lymphocytic leukemia (CLL) cells. The aim of this study was to show whether there is a relationship between the level of ROR1 surface expression in CLL cells and disease findings.
Akinci, Sema +6 more
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Blood Advances, 2017 : Dendritic cells (DCs) represent essential antigen-presenting cells that are critical for linking innate and adaptive immunity, and influencing T-cell responses.
Maria Dolores Lopez Robles +16 more
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In-Silico Drug discovery approach targeting receptor tyrosine kinase-like orphan receptor 1 for cancer treatment [PDF]
Scientific Reports, 2017 AbstractReceptor tyrosine kinases (RTK) are important cell signaling molecules that influence many cellular processes. Receptor tyrosine kinase such as orphan receptor 1 (Ror1), a surface antigen, is a member of the RTK family of Ror, which plays a crucial role in cancers that have high-grade histology.
Nath, Onkar +2 more
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PLoS ONE, 2019 Triple Negative Breast Cancer (TNBC), the most aggressive subtype of breast cancer, is characterized by the absence of hormone receptors usually targeted by hormone therapies like Tamoxifen.
Norman Fultang +7 more
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HemaSphere, 2019 Background:B‐cell chronic lymphocytic leukemia (CLL) is the most common haematological malignancy in advanced age. The clinical course of the disease is highly variable, therefore there is a need to investigate the various prognostic factors. The transmembrane receptor tyrosine kinase‐like orphan receptor 1 (ROR1) is upragulated in chronic lymphocytic ...
A. Senturk Yikilmaz +6 more
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