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Heterogeneous expression and role of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in small cell lung canceropenaire
Meta-Analysis of Survival Effects of Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1)
Medicina (Lithuania), 2022 Background and Objectives: Identification and targeting of membrane proteins in tumor cells is one of the key steps in the development of cancer drugs. The receptor tyrosine kinase-like orphan receptor (ROR) type 1 is a type-I transmembrane protein expressed in various cancer tissues, which is in contrast to its limited expression in normal tissues ...
So Yoon Park +2 more
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Acta Crystallographica Section F, Structural Biology Communications, 2022 Receptor tyrosine kinase-like orphan receptors (RORs) are monotopic membrane proteins belonging to the receptor tyrosine kinase (RTK) family. RTKs play a role in the control of most basic cellular processes, including cell proliferation, differentiation, migration and metabolism.
Maria Chiara Capillo, Federico Forneris
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Therapeutic approaches for targeting receptor tyrosine kinase like orphan receptor-1 in cancer cells
Expert Opinion on Therapeutic Targets, 2019There is a high expression of receptor tyrosine kinase like orphan receptor-1 (ROR-1), a tyrosine kinase receptor, in various tumor-cell types. ROR-1 is involved in many key processes in cancer including proliferation, survival and metastasis. Hence, ROR-1 is an attractive and promising therapeutic target.
Amir Mehdizadeh +2 more
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Receptor tyrosine kinase-like orphan receptor 1: a novel target for cancer immunotherapy
Expert Opinion on Therapeutic Targets, 2015Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the receptor tyrosine kinase family. ROR1 is selectively overexpressed in a number of solid and hematological malignancies without significant expression in normal adult tissues. There are also some lines of evidence, which support the critical role of ROR1 in tumorigenesis.
Fazel Shokri
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Receptor tyrosine kinase-like orphan receptor serves as a potential target in cancer immunotherapy
Journal of Leukocyte BiologyAbstract Receptor tyrosine kinase-like orphan receptor (ROR), consisting of ROR1 and ROR2, is a conserved family of receptor tyrosine kinase superfamily that plays crucial roles during embryonic development with limited expression in adult normal tissues.
Qi Zhao
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Cancer Treatment Reviews, 2019
Identification of membrane proteins expressed exclusively on tumor cells is a goal for cancer drug development. The receptor tyrosine kinase-like orphan receptor type 1 and 2 (ROR1/2), are type-I transmembrane proteins expressed in cancer but not in adult normal tissue.
Ramy R Saleh +2 more
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Identification of membrane proteins expressed exclusively on tumor cells is a goal for cancer drug development. The receptor tyrosine kinase-like orphan receptor type 1 and 2 (ROR1/2), are type-I transmembrane proteins expressed in cancer but not in adult normal tissue.
Ramy R Saleh +2 more
exaly +3 more sources