Results 111 to 120 of about 9,967 (136)

Receptor tyrosine kinase-like orphan receptors ROR1/2: Insights into the mechanism of action, inhibition, and therapeutic potential

2022
Archana Singh, Indrakant K Singh
exaly   +2 more sources

Heterogeneous expression and role of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in small cell lung cancer

Human Cell, 2022
The present study investigated the expression and role of ROR2 in small cell lung cancer (SCLC). To examine the expression of ROR2, 27 surgically resected SCLC tissue samples were immunostained for ROR2. Sixteen tissue samples were positive and some showed intratumor heterogeneity in staining intensity.
Mune Sanada, Masaya Yamazaki, Tatsuya Yamada, Kosuke Fujino, Shinji Kudoh, Yuki Tenjin, Haruki Saito, Noritaka Kudo, Younosuke Sato, Akira Matsuo, Makoto Suzuki, Takaaki Ito   +11 more
openaire   +2 more sources

Exploration of macrocyclic peptide binders to the extracellular CRD domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1)

Bioorganic & Medicinal Chemistry Letters, 2023
Elevated levels of receptor tyrosine kinase-like orphan receptor 1 (RORl) expression are observed in multiple hematological and solid tumors, but not in most of the healthy adult tissues, identifying ROR1 as an attractive target for tumor-specific therapy.
Jennifer X. Qiao, Mark R. Witmer, Ving Lee, Tammy C. Wang, Patrick C. Reid, Yuki Arioka, Glen Farr, Melissa Hill-Drzewi, Liang Schweizer, Aaron Yamniuk, Lin Cheng, Bozena Abramczyk, Martin Corbett, Deepa Calambur, Nicolas Szapiel, Rolf Ryseck, Paul Ponath, Michael A. Poss, Percy Carter   +18 more
openaire   +2 more sources

Use of the receptor tyrosine kinase-like orphan receptor 1 (ROR1) as a diagnostic tool in chronic lymphocytic leukemia (CLL)

Leukemia Research, 2011
Flow cytometry is commonly used to establish the diagnosis of chronic lymphocytic leukemia (CLL). A defined combination of antibodies discriminates between normal B cells and CLL cells (coexpression of CD5, CD19, and CD23). The receptor tyrosine-like orphan receptor one (ROR1) is an embryonic glycoprotein involved in several developmental processes. It
Christina Schmidt, Karl-Anton Kreuzer
exaly   +3 more sources

Purification and characterization of the extracellular region of human receptor tyrosine kinase like orphan receptor 2 (ROR2)

Protein Expression and Purification, 2019
Receptor tyrosine kinase like orphan receptor 2 (ROR2) is a co-receptor for some Wnt proteins including Wnt5a that activate the noncanonical Wnt/planar cell polarity (PCP) signaling pathway. Upregulation of ROR2 is associated with several cancer forms. The extracellular region of ROR2, which contains an immunoglobulin (Ig)-like domain, a Frizzled like ...
Yuan, Li, Xu, Han, Wenqing, Xu, Zihe, Rao, Xin, Li   +4 more
openaire   +2 more sources

Receptor Tyrosine Kinase-like Orphan Receptor 2 (Ror2) Expression Creates a Poised State of Wnt Signaling in Renal Cancer [PDF]

Journal of Biological Chemistry, 2013
Expression of the receptor tyrosine kinase-like orphan receptor 2 (Ror2) has been identified in an increasing array of tumor types and is known to play a role as an important mediator of Wnt signaling cascades. In this study, we aimed to clarify Ror2 interactions with the Wnt pathways within the context of renal cell carcinoma (RCC).
Neal R Rasmussen, Adam B Sendor, Matthew P Walker   +2 more
exaly   +3 more sources

Discovery of Novel Receptor Tyrosine Kinase-like Orphan Receptor 1 (ROR1) Inhibitors for Cancer Treatment

Journal of Medicinal Chemistry
Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncogenic membrane protein in several malignancies and has been considered an attractive target for the treatment of human cancers. In this study, structure-based virtual screening and structure optimization were conducted to identify novel ROR1 inhibitors.
Dongdong Luo, Xingyang Qiu, Qingquan Zheng, Yue Ming, Wencheng Pu, Ming Ai, Jianhua He, Yong Peng   +7 more
openaire   +2 more sources

Role of receptor tyrosine kinase like orphan receptor 2 in treatment-resistant prostate cancer

2020
Potent androgen receptor pathway inhibitors such as Enzalutamide (ENZ) and Abiraterone (Abi) have become the gold standard for patients with castration resistant prostate cancer (CRPC). However, treatment resistance is inevitable and all patients eventually become insensitive to these treatments.
openaire   +1 more source

Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) - a Putative Diagnostic Marker for Chronic Lymphocytic Leukemia (CLL).

Blood, 2009
Abstract Abstract 1587 Poster Board I-613 In chronic lymphocytic leukemia (CLL) WNT signaling is constitutively active and several members of this signaling pathway are uniformely upregulated in these cells. Apart from classical WNT receptors like FZD and LRP6, receptor tyrosine kinase-like orphan receptor 1
Sabrina Uhrmacher, Magdalena Hertweck, Julian Paesler, Felix Erdfelder, Alexandra Filipovich, Simon Jonas Poll-Wolbeck, Regina Razavi, Rajesh Kumar Gandhirajan, Iris Gehrke, Michael Hallek, Karl Anton Kreuzer   +10 more
openaire   +1 more source

Backbone and side-chain chemical shift assignments of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1)

Biomolecular NMR Assignments, 2018
Receptor tyrosine kinase-like orphan receptor 1 (ROR1) expresses at high level in many cancers and has been suggested as a potential therapeutic target. It was reported that the Kringle (KNG) domain of ROR1 extracellular region is involved in ROR1/ROR2 heterooligomerization.
Xiaofang Ma, Yingying Zhang, Bin Liu, Jiahui Yang, Kaifeng Hu   +4 more
openaire   +2 more sources