Results 181 to 190 of about 409,522 (315)

Clustering and a conformational switch drive activation of the mammalian receptor tyrosine kinase ROS1. [PDF]

Nat Commun
Li H, Zhang J, Li T, Wang Y, Alarcón CR, Klein DE.   +5 more
europepmc   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Autoregulation of the MET receptor tyrosine kinase by its intracellular juxtamembrane domain. [PDF]

Biochem J
Linossi EM, Espinoza CA, Estevam GO, Fraser JS, Jura N.   +4 more
europepmc   +1 more source

Long‐Term Ambient Benzene Exposure and Brain Disorders Among Urban Adults: Effect Modification by Genetic Susceptibility and Potential Mediation by Plasma Proteins

Advanced Science, EarlyView.
Low‐level ambient benzene exposure is associated with increased risks of multiple brain disorders in urban adults. Genetic susceptibility modifies these associations, while plasma proteomics points to potential biological pathways linking benzene exposure to adverse brain health.
Jianhui Guo, Xia Zhong, Petros Koutrakis, Carolina L. Zilli Vieira, Feifei Si, Yaqi Wang, Xinyao Lian, Yi Fan, Zhaokun Wang, Shaodan Huang, Jing Li   +10 more
wiley   +1 more source

Cholesterol promotes the formation of dimers and oligomers of the receptor tyrosine kinase ROR1. [PDF]

J Biol Chem
Ward A, Baeza-Ballesteros LJ, Schuck R, García-Murria MJ, Lamichhane R, Mingarro I, Barrera FN.   +6 more
europepmc   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Receptor Tyrosine Kinase Activation in Human Carcinoma Cells [PDF]

, 2004
Fischer, O., Fischer, Oliver, Fischer, Oliver Martin   +2 more
core  

Human brain and organoid transcriptomes reveal key receptor tyrosine kinase pathways and genetic signatures in Alzheimer's disease. [PDF]

Exp Mol Med
Shin S, Zhu X, Amartumur S, Lee T, Yu WJ, Park S, Etemadi N, Jamsranjav A, Kang R, Bak G, Lee D, Kim J, Han JW, Heo C, Cho H, Chang S, Mook-Jung I, Lee SE, Park JC.   +18 more
europepmc   +1 more source

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

Hand-foot skin reaction associated with vascular endothelial growth factor receptor tyrosine kinase inhibitors: a FAERS-based pharmacovigilance study. [PDF]

Front Med (Lausanne)
Chen J, Xu Q, Wang B, Sun H, Shu Q.
europepmc   +1 more source