Results 11 to 20 of about 409,522 (315)

Efficacy of Next-Generation EGFR-TKIs in Patients With Non-Small Cell Lung Cancer: A Meta-Analysis of Randomized Controlled Trials

Technology in Cancer Research & Treatment, 2020
Background: The efficacy of next-generation epidermal growth factor receptor-tyrosine kinase inhibitors in patients with advanced non-small cell lung cancer who have failed first-generation epidermal growth factor receptor-tyrosine kinase inhibitors ...
Yi-Tian Qi MM, Yi Hou PhD, Liang-Chen Qi MD   +2 more
doaj   +1 more source

The deleted in brachydactyly B domain of ROR2 is required for receptor activation by recruitment of Src. [PDF]

PLoS ONE, 2008
The transmembrane receptor 'ROR2' resembles members of the receptor tyrosine kinase family of signalling receptors in sequence but its' signal transduction mechanisms remain enigmatic.
Shiva Akbarzadeh, Lee M Wheldon, Steve M M Sweet, Sonia Talma, Faraz Khosravi Mardakheh, John K Heath   +5 more
doaj   +1 more source

The Relationship between IGF Pathway and Acquired Resistance to Tyrosine Kinase Inhibitors in Cancer Therapy

Frontiers in Bioscience-Landmark, 2023
The tyrosine kinase signaling pathway is an important pathway for cell signal transduction, and is involved in regulating cell proliferation, cell cycle, apoptosis and other essential biological functions.
Yanjing Peng, Jinjing Tan
doaj   +1 more source

Crystal structure of the kinase domain of a receptor tyrosine kinase from a choanoflagellate, Monosiga brevicollis.

PLoS ONE, 2023
Genomic analysis of the unicellular choanoflagellate, Monosiga brevicollis (MB), revealed the remarkable presence of cell signaling and adhesion protein domains that are characteristically associated with metazoans. Strikingly, receptor tyrosine kinases,
Teena Bajaj, John Kuriyan, Christine L Gee   +2 more
doaj   +1 more source

ISOLATION AND CHARACTERIZATION OF INSULIN RECEPTOR OF PLASMA MEMBRANES OF RAT LIVER CELLS AT MODEL OF TYPE 2 DIABETES [PDF]

Biotechnologia Acta, 2014
The insulin receptor was isolated from the liver cell membranes of control and diabetic rats. The protein purity was controlled by electrophoresis and Western blot.
T. I. Halenova, M. Y. Kuznetsova, O. M. Savchuk, L. I. Ostapchenko   +3 more
doaj   +1 more source

The Abl/Abi signaling links WAVE regulatory complex to Cbl E3 ubiquitin ligase and is essential for breast cancer cell metastasis

Neoplasia: An International Journal for Oncology Research, 2022
The family of Abelson interactor (Abi) proteins is a component of WAVE regulatory complex (WRC) and a downstream target of Abelson (Abl) tyrosine kinase.
Peixin Jiang, Suni Tang, Hogan Hudgins, Tate Smalligan, Xue Zhou, Anuja Kamat, Janaki Dharmarpandi, Tarek Naguib, Xinli Liu, Zonghan Dai   +9 more
doaj   +1 more source

Construction of a circRNA-miRNA-mRNA Regulated Pathway Involved in EGFR-TKI Lung Adenocarcinoma Resistance

Technology in Cancer Research & Treatment, 2021
Objectives: Epidermal growth factor receptor-tyrosine kinase inhibitors are widely used for lung epidermal growth factor receptor-positive lung adenocarcinomas, but acquired resistance is inevitable.
Chenyue Dai MM, Bing Liu MD, Shaolei Li PhD, Yang Hong PhD, Jiahui Si PhD, Ying Xiong MSc, Nan Wu MD, Yuanyuan Ma PhD   +7 more
doaj   +1 more source

Resistance mechanisms of epidermal growth factor receptor tyrosine kinase inhibitors in non‐small cell lung cancer patients: A meta‐analysis

Thoracic Cancer, 2021
Background Differences in the resistance mechanisms of epidermal growth factor receptor tyrosine kinase inhibitors in patients with non‐small cell lung cancer (NSCLC) harboring epidermal growth factor receptor mutations are unknown.
Nobuaki Kobayashi, Seigo Katakura, Chisato Kamimaki, Kohei Somekawa, Nobuhiko Fukuda, Katsushi Tanaka, Keisuke Watanabe, Nobuyuki Horita, Yu Hara, Hongmei Piao, Takeshi Kaneko   +10 more
doaj   +1 more source

Receptor tyrosine kinases in carcinogenesis

Oncology Letters, 2016
[This retracts the article DOI: 10.3892/ol.2016.5200.].
Zhang, Xiao-Ying, Zhang, Pei-Ying
openaire   +4 more sources

PTK2 and PTPN11 expression in myelodysplastic syndromes

Clinics, 2013
OBJECTIVE: The aim of this study was to evaluate the expression of protein tyrosine kinase 2 and protein tyrosine phosphatase non-receptor type 11, which respectively encode focal adhesion kinase protein and src homology 2 domain-containing protein ...
Mariana Lazarini, Joao Agostinho Machado-Neto, Leticia Frohlich Archangelo, Bruna Fernandes Mendes-Silva, Carolina Louzao Bigarella, Fabiola Traina, Sara Teresinha Olalla Saad   +6 more
doaj   +1 more source