Results 71 to 80 of about 409,522 (315)

Receptor tyrosine kinases and their activation in melanoma [PDF]

Pigment Cell & Melanoma Research, 2011
SummaryReceptor tyrosine kinases (RTKs) and their downstream signalling pathways have long been hypothesized to play key roles in melanoma development. A decade ago, evidence was derived largely from animal models, RTK expression studies and detection of activated RAS isoforms in a small fraction of melanomas.
Easty, David, Gray, Steven, O'Byrne, Kenneth, O'Donnell, Dearbhaile, Bennett, Dorothy   +4 more
openaire   +4 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The role of receptor tyrosine kinase signalling in HER-2-positive cells and trastuzumab (Herceptin) resistance in breast cancer [PDF]

, 2009
HER-2 gene amplification or overexpression occurs in approximately 25 % of breast cancers, and trastuzumab (Tmab) is a monoclonal antibody currently used to treat patients with HER-2-overexpressing breast cancer.
Browne, Brigid
core  

Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway

, 2003
Background: The regulation of platelet function by pharmacological agents that modulate platelet signaling haspharmacolo proven a successful approach to the prevention of thrombosis.
Cicmil, M, Jordan, P.A., Sage, T., C. M. Williams, G. P. Hubbard, T. Sage, Lovegrove, J.A., Stevens, J M; id_orcid, P. A. Jordan, J. M. Gibbins, Hubbard, G.P., M. Cicmil, Sage, T, Gibbins, J.M., Williams, C M, Williams, C.M., Gibbins, J M, Jordan, P A, Lovegrove, J A, Hubbard, G P, Stevens, J.M., J. A. Lovegrove, J. M. Stevens, Cicmil, M.   +23 more
core   +1 more source

A role for Syk-kinase in the control of the binding cycle of the β2 integrins (CD11/CD18) in human polymorphonuclear neutrophils [PDF]

, 2003
A fine control of β2 integrin (CD11/CD18)-mediated firm adhesion of human neutrophils to the endothelial cell monolayer is required to allow ordered emigration.
Walzog, Barbara, Prange, Peggy, Willeke, Thomas, Zahler, Stefan, Schymeinsky, Jürgen   +4 more
core   +1 more source

Cell Signaling by Receptor Tyrosine Kinases [PDF]

Cell, 2010
Recent structural studies of receptor tyrosine kinases (RTKs) have revealed unexpected diversity in the mechanisms of their activation by growth factor ligands. Strategies for inducing dimerization by ligand binding are surprisingly diverse, as are mechanisms that couple this event to activation of the intracellular tyrosine kinase domains.
Lemmon, Mark A., Schlessinger, Joseph
openaire   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway

BMC Biology, 2004
Background Gab1 is a docking protein that recruits phosphatidylinositol-3 kinase (PI-3 kinase) and other effector proteins in response to the activation of many receptor tyrosine kinases (RTKs).
Lamothe Betty, Mattoon Dawn R, Lax Irit, Schlessinger Joseph   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Syk-mediated translocation of PI3Kδ to the leading edge controls lamellipodium formation and migration of leukocytes [PDF]

, 2007
The non-receptor tyrosine kinase Syk is mainly expressed in the hematopoietic system and plays an essential role in β2 integrin-mediated leukocyte activation.
Jakus, Zoltán, Walzog, Barbara, Cornelia Then, Scharffetter-Kochanek, Karin, Then, Cornelia, Victor L. J. Tybulewicz, Barbara Walzog, Ronald Gerstl, Zoltán Jakus, Sindrilaru, Anca, Jürgen Schymeinsky, Schymeinsky, Juergen, Anca Sindrilaru, Gerstl, Ronald, Tybulewicz, Victor L. J., Victor L J Tybulewicz, Karin Scharffetter-Kochanek, Schymeinsky, Jürgen, Tybulewicz, Victor LJ   +18 more
core   +1 more source