Results 111 to 120 of about 83,663 (312)

A role for the locus coeruleus in the analgesic efficacy of N-acetylaspartylglutamate peptidase (GCPII) inhibitors ZJ43 and 2-PMPA

Molecular Pain, 2017
N-acetylaspartylglutamate (NAAG) is the third most prevalent and widely distributed neurotransmitter in the mammalian nervous system. NAAG activates a group II metabotropic glutamate receptor (mGluR3) and is inactivated by an extracellular enzyme ...
Takahiro Nonaka, Toshihiko Yamada, Tatsuhiro Ishimura, Daiying Zuo, John R Moffett, Joseph H Neale, Tatsuo Yamamoto   +6 more
doaj   +1 more source

Jervell and Lange‐Nielsen Syndrome Related Clinical Genetics and Experimental Models

Pediatric Discovery, EarlyView.
ABSTRACT Jervell and Lange‐Nielsen syndrome (JLNS) is defined by electrocardiographic QT prolongation and sensorineural hearing loss, caused by homozygous or compound heterozygous variants in KCNQ1 and/or KCNE1. KCNQ1 encodes the alpha subunit Kv7.1 of the ion channels accountable for slow delayed rectifier potassium currents (IKs), whereas KCNE1 ...
Yafei Zhou, Christopher L.‐H. Huang, Ying Yang, Yanmin Zhang   +3 more
wiley   +1 more source

The effects of ganglionic and adrenergic blockade on the circulation of the young chimpanzee Final technical report, 1 Oct. 1963 - 30 Apr. 1965 [PDF]

Ganglionic and adrenergic blockade effects on circulatory system studied on young ...
Carter, V. L., Schoenfeld, C. D., Warren, J. V., Weissler, A. M.   +3 more
core   +1 more source

Kaposiform hemangioendothelioma: Diagnosis and treatment

Pediatric Investigation, EarlyView.
Vascular endothelial growth factor‐C (VEGF‐C)/vascular endothelial growth factor receptor‐3 (VEGFR‐3) and angiopoietin‐2 (Ang‐2)/tyrosine kinase with immunoglobulin‐like and EGF‐like domain 2 (TIE2) signaling pathways play an important role in lymphangiogenesis.
Yi Tian, Yuanyuan Tian, Li Wei, Zigang Xu, Li Li, Lin Ma   +5 more
wiley   +1 more source

Interaction between Nuclear Receptor and Alpha-Adrenergic Agonist Subtypes in Metabolism and Systemic Hemodynamics of Spontaneously Hypertensive Rats

PPAR Research
Partial and full PPAR-γ agonists have shown promising effects and antihypertensive and antidiabetic agents through increased plasma adiponectin concentration.
Sheryar Afzal, Munavvar Abdul Sattar, Ibrahim Albokhadaim, Ali Attiq, Mahmoud Kandeel, Aimi Syamima Abdul Manap, Sameer M. Alhojaily   +6 more
doaj   +1 more source

An Investigation of Novel Series of 2-Thioxo-1,3-dithiol-carboxamides as Potential Antispasmodic Agents: Design, Synthesis via Coupling Reactions, Density Functional Theory Calculations, and Molecular Docking

Molecules
This study reports the synthesis of 2-thioxo-1,3-dithiol-carboxamides (TDTCAs) under mild conditions at room temperature using HBTU as a coupling agent, which significantly improved amide bond formation. The synthesized compounds were characterized using
Riham Sghyar, Mouad Lahyaoui, Noura Aflak, Oussama Moussaoui, Alae Chda, Rachid Bencheikh, El Mestafa El Hadrami, Nada Kheira Sebbar, Ashwag S. Alanazi, Mohamed Hefnawy   +9 more
doaj   +1 more source

Gαq and its \u3ci\u3eAkt\u3c/i\u3eions [PDF]

, 2006
No abstract ...
Eckhart, Andrea D., Harris, David M., Koch, Walter J.   +2 more
core   +1 more source

Role of novel automated methods in pulse signal analysis to screen for sleep‐disordered breathing among patients on chronotropic medications

Sleep Research, EarlyView.
Abstract Study objectives To investigate the use of automated analysis to detect heart rate accelerations (HRAs) to screen for sleep‐disordered breathing (SDB) among patients who use chronotropic medications. Methods Nocturnal polysomnography (NPSG) recordings from 933 participants in the Sleep Heart Health Study were analyzed using an automated method
Nabila Ahmed, Moustafa Habra, Raya Nashef, Scott Maresh, Abed Najjar, Shivapriya Chandu, Adhithi Athikumar, Omar Ismail, Laurel A. Ravelo, Paul E. Peppard, M. Safwan Badr, Abdulghani Sankari   +11 more
wiley   +1 more source

Effects of central imidazolinergic and alpha2-adrenergic activation on water intake

Brazilian Journal of Medical and Biological Research, 2001
Non-adrenergic ligands that bind to imidazoline receptors (I-R), a selective ligand that binds to alpha2-adrenoceptors (alpha2-AR) and mixed ligands that bind to both receptors were tested for their action on water intake behavior of 24-h water-deprived ...
Sugawara A.M., Miguel T.T., Pereira D.T.B., Menani J.V., De Luca Jr. L.A.   +4 more
doaj  

Autonomic Regulation of Splanchnic Circulation

Canadian Journal of Gastroenterology, 1991
The role of the autonomic nervous system in circulatory regulation of the splanchnic organs (stomach, small intestine, colon, liver, pancreas and spleen) is reviewed.
Kathleen A Fraser, Samuel S Lee
doaj   +1 more source