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The B-cell antigen receptor of the five immunoglobulin classes
Nature, 1991Several proteins associate with surface IgM to form the antigen receptor. We show that just two, the alpha and beta associated chains, are sufficient to reconstitute an IgM surface receptor in fibroblasts. Contrary to expectation, a common alpha chain associates with all five immunoglobulin classes. We propose that B-cell antigen receptors consist of a
A R, Venkitaraman +3 more
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Is expression of the b-cell antigen receptor repertoire chaotic?
Research in Immunology, 1992terization of uncommited B cell precursors from fetal liver at 12 days of gestation. EMBO J., 11, 593-601. Cumano, A., Paige, C.J., Iscove, N.N. & Brady, G. (1982), Bipotential precursors of B cells and macrophages identified in murine fetal liver at day 12 of gestation. Nature (Lond.), 356, 612-615. Kalled, S.L. & Broder, P.H.
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GENETIC ANALYSIS OF B CELL ANTIGEN RECEPTOR SIGNALING
Annual Review of Immunology, 1999▪ Abstract In B lymphocytes, a signaling complex that contributes to cell fate decisions is the B cell antigen receptor (BCR). Data from knockout experiments in cell lines and mice have revealed distinct functions for the intracellular protein tyrosine kinases (Lyn, Syk, Btk) in BCR signaling and B cell development.
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To make antibodies or not: signaling by the B-cell antigen receptor
Trends in Pharmacological Sciences, 2002Antibodies produced by B cells play an essential role in protecting against disease-causing pathogens. B cells detect the presence of pathogens via B-cell antigen receptors (BCRs), which consist of a transmembrane form of an antibody that is associated with a signaling subunit. Signaling by BCRs not only initiates antibody production but also regulates
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Critical Care Management of Chimeric Antigen Receptor T-Cell Therapy Recipients
Ca-A Cancer Journal for Clinicians, 2022Sandrine Valadè +2 more
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Signalling Function of the B‐Cell Antigen Receptors
Immunological Reviews, 1993K M, Kim, G, Alber, P, Weiser, M, Reth
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