Results 91 to 100 of about 1,196,650 (308)

P1 receptors and cytokine secretion [PDF]

, 2007
Evidence has accumulated in the last three decades to suggest tissue protection and regeneration by adenosine in multiple different cell types. Adenosine produced in hypoxic or inflamed environments reduces tissue injury and promotes repair by receptor ...
Stefania Ceruti, S. Ceruti, M.P. Abbracchio, Maria P. Abbracchio   +3 more
core   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Putative Transcriptomic Biomarkers in the Inflammatory Cytokine Pathway Differentiate Major Depressive Disorder Patients from Control Subjects and Bipolar Disorder Patients [PDF]

, 2014
Mood disorders consist of two etiologically related, but distinctly treated illnesses, major depressive disorder (MDD) and bipolar disorder (BPD). These disorders share similarities in their clinical presentation, and thus show high rates of misdiagnosis.
Farmer, A., Farmer, Anne E, Powell, Timothy R, Matthews Keith, Day, Richard K, Anne E. Farmer (215007), Powell Timothy R., Farmer, Anne E., Hosang Georgina M., Farmer Anne E., Martin, C, Leonard C. Schalkwyk (27674), Day, Richard K., Cohen-Woods Sarah, Katherine E. Tansey (128003), Cohen-Woods, Sarah, Richard K Day, Timothy R. Powell (533562), McGuffin Peter, Day Richard K., Farmer, AE, Matthews, K, Hosang, GM, Schalkwyk, Leonard, Schalkwyk, L., Timothy R Powell, Keith Matthews (22202), Tansey, Katherine E., Powell, TR, Matthews, K., Tansey, Katherine E, Powell, Timothy; id_orcid, Georgina M Hosang, Sarah Cohen-Woods (214940), Tansey, K., Martin, Charlotte, Martin, C., Hosang, Georgina, McGuffin, P., Tansey Katherine E., D'Souza Ursula M., Matthews, Keith, Leonard C Schalkwyk, Schalkwyk Leonard C., Charlotte Martin (533565), Day, RK, Matthews, Kieth, Anne E Farmer, Martin Charlotte, Hosang, G., D'Souza, Ursula M., Charlotte Martin, Powell, T., McGuffin, P, Schalkwyk, LC, Peter McGuffin, Tansey, KE, Georgina M. Hosang (533564), Ursula M D'Souza, Sarah Cohen-Woods, Schalkwyk, Leonard C., D'Souza, U., D'Souza, Ursula M, Keith Matthews, Peter McGuffin (51507), Day, R., Hosang, Georgina M., Katherine E Tansey, McGuffin, Peter, Ursula M. D'Souza (533563), Cohen-Woods, S, McGuffin, Peter W, Schalkwyk, Leonard C, Cohen-Woods, S., Powell, Timothy R., D'Souza, UM, Richard K. Day (533566)   +76 more
core   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

eLife, 2019
Cytokines activate signaling via assembly of cell surface receptors, but it is unclear whether modulation of cytokine-receptor binding parameters can modify biological outcomes.
Jonathan Martinez-Fabregas, Stephan Wilmes, Luopin Wang, Maximillian Hafer, Elizabeth Pohler, Juliane Lokau, Christoph Garbers, Adeline Cozzani, Paul K Fyfe, Jacob Piehler, Majid Kazemian, Suman Mitra, Ignacio Moraga   +12 more
doaj   +1 more source

Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors. [PDF]

, 2013
Recent investigations have revealed that the genetic deletion of P2X7 receptors (P2rx7) results in an antidepressant phenotype in mice. However, the link between the deficiency of P2rx7 and changes in behavior has not yet been explored.
Zsilla Gabriella, Csölle Cecília, Csölle, Cecília, Illes Peter, Flóra Gölöncsér, Gabriella Zsilla, Mária Baranyi, Sperlágh, Beáta, Baranyi, Mária, Kittel Ágnes, Peter Illes, Baranyi Mária, Beáta Sperlágh, Vizi E. Szilveszter, E Sylvester Vizi, Zsilla, Gabriella, Papp Edit, Gölöncsér Flóra, Illés, Péter, Gölöncsér, Flóra, E. Sylvester Vizi, Sperlágh Beáta, Illes P, Vizi, E. Szilveszter, Papp, Edit, Edit Papp, Kittel, Ágnes, Agnes Kittel, Cecilia Csölle, Vizi E. Sylvester   +29 more
core   +2 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Participation of pro-inflammatory cytokines in neuropathic pain evoked by chemotherapeutic oxaliplatin via central GABAergic pathway

Molecular Pain, 2018
Background Neuropathic pain is observed in patients as chemotherapeutic oxaliplatin is used to treat metastatic digestive tumors; however, the mechanisms responsible for hyperalgesia are not well understood.
Dongsheng Xu, Hui Zhao, Han Gao, Huiling Zhao, Dandan Liu, Jing Li   +5 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Five layers of receptor signalling in γδ T cell differentiation and activation

Frontiers in Immunology, 2015
The contributions of gamma-delta T cells to immunity to infection or tumours critically depend on their activation and differentiation into effectors capable of secreting cytokines and killing infected or transformed cells.
Sérgio T. Ribeiro, Julie C. Ribot, Bruno eSilva-Santos   +2 more
doaj   +1 more source