Results 141 to 150 of about 3,641,661 (311)

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

PTPN6/SHP-1 in autoimmune disease: immune tolerance, regulatory mechanisms, and therapeutic targeting. [PDF]

Front Immunol
Chang RC, Lasalle C, Wang Y, Markovics A, Amber KT, Mansini AP.   +5 more
europepmc   +1 more source

T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma.

Immunity, 2008
Xuexian O. Yang, B. Pappu, R. Nurieva, A. Akimzhanov, H. Kang, Yeonseok Chung, Li Ma, Bhavin Shah, Athanasia D. Panopoulos, K. Schluns, S. Watowich, Qiang Tian, A. Jetten, C. Dong   +13 more
semanticscholar   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Resveratrol Attenuates Heat Stress-Induced Luteal Injury Through Modulation of Oxidative Stress and Cytokine-Chemokine Inflammatory Networks in Pregnant Mice. [PDF]

Antioxidants (Basel)
Tariq M, Quddus A, Victor KKAS, Beshah KH, Yan Y, Mao D.   +5 more
europepmc   +1 more source

Signaling to NF-?B by Toll-like receptors

, 2007
T. Kawai, S. Akira
semanticscholar   +1 more source

Coaxially Electrospun Myocardial dECM‐ Based Nanofibrous Scaffolds Demonstrate Enhanced Cardiomyocyte Biocompatibility

Advanced Healthcare Materials, EarlyView.
Our coaxial electrospinning system is capable of incorporating decellularized myocardial extracellular matrix in a core‐sheath configuration, creating nanofibrous scaffolds. These scaffolds, in turn, support the maintenance of functional cardiomyocytes adhered to the surface of these bioactive scaffolds.
Dhanusha N. Rajapakse, Mahtab Khodadadi, Kiran M. Ali, Suh Hee Cook, Bryson T. Proctor, Tanya Upadhyay, Daxian Zha, Fatema Tuj Jahura, Marziyeh Boosaliki, Jessica M. Gluck   +9 more
wiley   +1 more source

Human neutrophils recognize group B streptococci <i>via</i> formylated peptide receptors and toll-like receptor 8. [PDF]

Front Immunol
Fiore L, De Gaetano GV, Grasso F, Coppolino F, Famà A, Stifano M, Petrungaro A, Vita F, Quartarone E, Cipollina C, Lentini G, Beninati C.   +11 more
europepmc   +1 more source

Structural design and molecular evolution of a cytokine receptor superfamily.

Proceedings of the National Academy of Sciences of the United States of America, 1990
J. Bazan
semanticscholar   +1 more source