Results 171 to 180 of about 287,271 (313)

Selective degradation processes in plants are not limited to autophagy. [PDF]

Plant Cell Rep
Michalak KM, Bagniewska-Zadworna A.
europepmc   +1 more source

GSH‐Responsive Nanoparticles Enhance Hepatocellular Carcinoma Immunotherapy Through Synergistic Effects of Cuproptosis and PI3K Inhibitor Combination

Advanced Science, EarlyView.
ABSTRACT Cuproptosis, an emerging form of programmed cell death, is capable of inducing mitochondrial dysfunction. Moreover, the PI3K‐AKT‐mTOR signaling pathway contributes to tumor cell progression by reprogramming mitochondrial morphology and function.
Lei Wu, Jintong Na, Xiyu Liu, Dongsheng Tang, Zhungang Yang, Zheng Cao, Xinyue He, Haihua Xiao, Liping Zhong, Yuan Liao, Yongxiang Zhao   +10 more
wiley   +1 more source

Gene expression regulation by Ca²⁺ signaling: an updated systematic review. [PDF]

Cell Mol Biol Lett
Zou M, Wang H, Zeng X, Zhang X.
europepmc   +1 more source

Synthesis and intracellular transport of mitochondrial proteins [PDF]

, 1985
A Lustig, A Lustig, A Ohashi, A Viebrock, AJ Lamb, AP Autor, AS Lewin, AS Lewin, B Hennig, B Schmidt, BE Roberts, BG Barrell, C Cote, C Zwizinski, CJ Leaver, DI Meyer, DI Meyer, DL Stigall, DM Kolansky, E Komar, E Marra, E Pratje, E Schmelzer, G Attardi, G Blobel, G Daum, G Daum, G Hallermayer, G Hallermayer, G Kreibich, G Kreil, G Macino, G Reid, G Schatz, G Schatz, G Schatz, G Srivastava, GC Shore, GC Shore, H Freitag, H Koehler, H Korb, H Riezman, H Weiss, IG Macreadie, IZ Ades, IZ Ades, J Kaput, JG Conboy, JP Kraus, K Mihara, K Mihara, K Mihara, K Watanabe, L Ernster, L Randall, LA Grivell, LE Aziz, M Inouye, M Klingenberg, M Klingenberg, M Maccechini, M Mori, M Mori, M Schleyer, M Suissa, M Teintze, M Wikstrom, M Yamamoto, M-L Maccechini, MA Harmey, MA Harmey, MD Hampsey, MM Mueckler, N Cerletti, N Nabi, N Nelson, NK Bhat, P Boehni, P Boehni, P Boogart van den, P Borst, P Borst, P Borst, P McAda, P Sonderegger, P Walter, PC Heinrich, PC Kreibich, PG Adolphus, R Jaussi, R Michel, R Sakakibara, R Zimmermann, R Zimmermann, R Zimmermann, R Zimmermann, RE Kellems, RE Kellems, RO Poyton, S Matsuura, S Miura, S Passarella, S Werner, SD Emr, SM Gasser, SM Gasser, SM Gasser, T Hunt, T Monta, T Oda, VA Rucker, W Neupert, W Wickner, Y Kamisaki, Y Raymond, Y Sagara, Y Yoshida   +117 more
core   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

Rheostats, not switches: Nuclear receptor dosage tunes somatic-to-iPSC reprogramming. [PDF]

Stem Cell Reports
Chronis C.
europepmc   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Importin α1 contributes to Venezuelan equine encephalitis virus-induced cell death, but is not required for the capsid-mediated blockage of nucleocytoplasmic trafficking. [PDF]

Front Microbiol
Jamiu AT, Akhrymuk I, Boyer G, Petruncio GM, Akhrymuk M, Delfing BM, Foreman HC, Foreman KW, Klimov DK, Paige M, Kehn-Hall K.   +10 more
europepmc   +1 more source

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source