Results 101 to 110 of about 673,565 (253)

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Neuromorphic Devices and Computing for Sensing, Memory, and Control

Advanced Science, EarlyView.
This review introduces neuromorphic devices made from diverse materials. These devices mimic neuronal functions and architectures and, when integrated with artificial or biological computing, can form closed loops with neurons for pressure, optical, acoustic, and biochemical sensing and modulation.
Zhengguang Zhu, Nicholas Schaffer, Xiao Yang   +2 more
wiley   +1 more source

Dopamine /

, 2005
Dopamine is a major neurotransmitter of the brain involved in the control of movement, emotion, and cognition; disturbance in dopamine function is associated with disorders like Parkinsons disease, schizophrenia and attention deficit hyperactivity ...
Dunnett, S. B.(Stephen B.)
core  

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

The transfection of BDNF to dopamine neurons potentiates the effect of dopamine D3 receptor agonist recovering the striatal innervation, dendritic spines and motor behavior in an aged rat model of Parkinson's disease.

PLoS ONE, 2015
The progressive degeneration of the dopamine neurons of the pars compacta of substantia nigra and the consequent loss of the dopamine innervation of the striatum leads to the impairment of motor behavior in Parkinson's disease.
Luis F Razgado-Hernandez, Armando J Espadas-Alvarez, Patricia Reyna-Velazquez, Arturo Sierra-Sanchez, Veronica Anaya-Martinez, Ismael Jimenez-Estrada, Michael J Bannon, Daniel Martinez-Fong, Jorge Aceves-Ruiz   +8 more
doaj   +1 more source

Identification of a domain which affects kinetics and antagonistic potency of clozapine at 5-HT3 receptors. [PDF]

, 2009
The widely used atypical antipsychotic clozapine is a potent competitive antagonist at 5-HT(3) receptors which may contribute to its unique psychopharmacological profile. Clozapine binds to 5-HT(3) receptors of various species.
Gerhard Rammes, Caroline Nothdurfter, Tanasic, S., Rammes, G., Rupprecht, R., Eisensamer, Brigitte, Zieglgänsberger Walter, Christine Hosp, Tanasic, Sascha, Hosp Christine, Walter Zieglgänsberger, Rupprecht Rainer, Rammes, Gerhard, Sascha Tanasic, Hosp, C., Rammes Gerhard, Nothdurfter, C., Tanasic Sascha, Rupprecht, Rainer, Nothdurfter Caroline, Brigitte Eisensamer, Eisensamer, B., Zieglgänsberger, Walter, Zieglgänsberger, W., Hosp, Christine, Rainer Rupprecht, Nothdurfter, Caroline, Eisensamer Brigitte, Rammes, G;Hosp, C;Eisensamer, B;Tanasic, S;Nothdurfter, C;Zieglgänsberger, W;Rupprecht, R   +28 more
core   +2 more sources

Thermal‐Ionic Coupling in Transpiration‐Inspired Janus Nanofiber Membranes: Synergistic Dry‐Wet Interface Engineering for Solar‐Driven Electricity Generation

Advanced Science, EarlyView.
A transpiration‐inspired Janus nanofiber membrane creates a persistent dry‐wet interface that couples localized solar heating with hydration‐induced ion regulation. The asymmetric architecture sustains directional water and ion transport, suppresses salt accumulation, and enables simultaneous seawater evaporation and stable electricity generation ...
Qin Su, Haidi Wu, Tingting Zheng, Di He, Huaiguo Xue, Longcheng Tang, Yongqian Shi, Xuejun Lai, Jiefeng Gao, Wancheng Gu, Jun Yan   +10 more
wiley   +1 more source

Probing Cortical Sites of Antipsychotic Drug Action with in vivo Receptor Imaging

Behavioural Neurology, 2000
Imaging receptors using radioactive ligands has allowed direct determination of the sites of action of antipsychotic drugs. Initial studies relating antipsychotic drug efficacy to action at striatal dopamine D2-like receptors have recently been ...
P. Shaw, L. S. Pilowsky
doaj   +1 more source

A role for accumbal glycine receptors in modulation of dopamine release by the glycine transporter-1 inhibitor Org25935

Frontiers in Psychiatry, 2011
Accumbal glycine modulates basal and ethanol-induced dopamine levels in the nucleus accumbens (nAc) as well as voluntary ethanol consumption. Also, systemic administration of the glycine transporter-1 inhibitor Org25935 elevates dopamine levels in nAc ...
Helga eHöifödt Lidö, Mia eEricson, Hugh eMarston, Bo eSöderpalm, Bo eSöderpalm   +4 more
doaj   +1 more source

A Photothermally Amplified Enzyme–Nitric Oxide Co‐Regulatory System Reprograms Pathological ECM–Fibroblast Crosstalk to Alleviate Hypertrophic Scarring

Advanced Science, EarlyView.
An enzyme–nitric oxide (NO) co‐regulatory strategy reprograms pathological extracellular matrix (ECM)–fibroblast crosstalk in hypertrophic scars. Enzymatic degradation of pre‐existing ECM relieves aberrant mechanical cues, while NO‐mediated fibroblast phenotypic modulation restrains excessive collagen synthesis.
Junzhe Fu, Fan Jia, Yixian Mu, Wanzhe Liu, Dingqi Tang, Qiao Jin, Jian Ji, Youxiang Wang   +7 more
wiley   +1 more source