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Dopamine receptors and hypertension
Current Hypertension Reports, 2008Dopamine plays an important role in regulating renal function and blood pressure. Dopamine synthesis and dopamine receptor subtypes have been shown in the kidney. Dopamine acts via cell surface receptors coupled to G proteins; the receptors are classified via pharmacologic and molecular cloning studies into two families, D1-like and D2-like.
Anees Ahmad Banday +1 more
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1981
Publisher Summary This chapter discusses the characterization of dopamine receptor subtypes, and characteristics of radioligand-binding to dopamine receptors, and its application for neurology and psychiatry. Recently, the function of dopamine in the brain has been elevated from that of a precursor for the neurotransmitter norepinephrine to a ...
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Publisher Summary This chapter discusses the characterization of dopamine receptor subtypes, and characteristics of radioligand-binding to dopamine receptors, and its application for neurology and psychiatry. Recently, the function of dopamine in the brain has been elevated from that of a precursor for the neurotransmitter norepinephrine to a ...
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Annals of Clinical Psychiatry, 1994
This paper reviews recent developments in dopamine receptor biology, with an emphasis on our recent understanding of the anatomical locations of where various genes for the dopamine receptors are expressed. At least five genes encoding dopamine receptors have been discovered. These five receptors have distinct pharmacological profiles as well as unique
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This paper reviews recent developments in dopamine receptor biology, with an emphasis on our recent understanding of the anatomical locations of where various genes for the dopamine receptors are expressed. At least five genes encoding dopamine receptors have been discovered. These five receptors have distinct pharmacological profiles as well as unique
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Receptors | Dopamine Receptors
Encyclopedia of Biological Chemistry III, 2021semanticscholar +1 more source
Comparative and General Pharmacology, 1971
Abstract 1. 1. This review considers the evidence for specific dopamine receptors in the mammalian peripheral vascular system, the mammalian central nervous system, and in the brain of Helix aspera. 2. 2. From the evidence of structure-activity studies on dog kidney and snail brain it seems that dopamine receptors show a higher degree of ...
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Abstract 1. 1. This review considers the evidence for specific dopamine receptors in the mammalian peripheral vascular system, the mammalian central nervous system, and in the brain of Helix aspera. 2. 2. From the evidence of structure-activity studies on dog kidney and snail brain it seems that dopamine receptors show a higher degree of ...
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Dopamine receptor agonists: selectivity and dopamine D1 receptor efficacy
European Journal of Pharmacology: Molecular Pharmacology, 1990Dopamine receptor selectivity was investigated for a number of dopamine receptor agonists. In vitro, the benzazepine derivatives, e.g., SKF 38393 and SKF 75670 as well as the isoquinoline derivatives, SKF 89626 and SKF 89615, were D1 receptor-selective. All other compounds like apomorphine, CY 208-243, 6,7-ADTN and 3-PPP were either D2-selective or did
Jens Aas Jansen, Peter H. Andersen
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Polypharmacology of dopamine receptor ligands
Progress in Neurobiology, 2016Most neurological diseases have a multifactorial nature and the number of molecular mechanisms discovered as underpinning these diseases is continuously evolving. The old concept of developing selective agents for a single target does not fit with the medical need of most neurological diseases.
BUTINI, STEFANIA +10 more
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Schizophrenia and dopamine receptors
European Neuropsychopharmacology, 2013Schizophrenia patients are behaviorally supersensitive to dopamine-like drugs such as amphetamine or methylphenidate, meaning that patients respond to such drugs with increased psychotic symptoms, as compared to control subjects. A basis of such supersensitivity may be an increased pre-synaptic release of dopamine or a post-synaptic elevation of D2 ...
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American Journal of Hypertension, 1990
Since 1979 when two subtypes of peripheral dopamine receptors (DA1 and DA2) were first proposed, much progress has been made to confirm such a view. Cumulative experience with the dog in vivo models suggests that the potency order: fenoldopam greater than dopamine greater than dipropyl dopamine greater than apomorphine characterizes the DA1 receptor ...
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Since 1979 when two subtypes of peripheral dopamine receptors (DA1 and DA2) were first proposed, much progress has been made to confirm such a view. Cumulative experience with the dog in vivo models suggests that the potency order: fenoldopam greater than dopamine greater than dipropyl dopamine greater than apomorphine characterizes the DA1 receptor ...
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2001
Publisher Summary This chapter provides an overview of the role of the Dl-like dopamine receptors in nervous system function. The goal is to provide a broader, integrated overview that relates the structure and function of these interesting receptors to how the D1 receptors may interact with human neurological and psychiatric diseases. The peripheral
Cindy P. Lawler +4 more
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Publisher Summary This chapter provides an overview of the role of the Dl-like dopamine receptors in nervous system function. The goal is to provide a broader, integrated overview that relates the structure and function of these interesting receptors to how the D1 receptors may interact with human neurological and psychiatric diseases. The peripheral
Cindy P. Lawler +4 more
openaire +3 more sources