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Polypharmacology of dopamine receptor ligands
Progress in Neurobiology, 2016Most neurological diseases have a multifactorial nature and the number of molecular mechanisms discovered as underpinning these diseases is continuously evolving. The old concept of developing selective agents for a single target does not fit with the medical need of most neurological diseases.
S. Butini +10 more
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American Journal of Hypertension, 1990
Since 1979 when two subtypes of peripheral dopamine receptors (DA1 and DA2) were first proposed, much progress has been made to confirm such a view. Cumulative experience with the dog in vivo models suggests that the potency order: fenoldopam greater than dopamine greater than dipropyl dopamine greater than apomorphine characterizes the DA1 receptor ...
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Since 1979 when two subtypes of peripheral dopamine receptors (DA1 and DA2) were first proposed, much progress has been made to confirm such a view. Cumulative experience with the dog in vivo models suggests that the potency order: fenoldopam greater than dopamine greater than dipropyl dopamine greater than apomorphine characterizes the DA1 receptor ...
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2001
Publisher Summary This chapter provides an overview of the role of the Dl-like dopamine receptors in nervous system function. The goal is to provide a broader, integrated overview that relates the structure and function of these interesting receptors to how the D1 receptors may interact with human neurological and psychiatric diseases. The peripheral
Cindy P. Lawler +4 more
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Publisher Summary This chapter provides an overview of the role of the Dl-like dopamine receptors in nervous system function. The goal is to provide a broader, integrated overview that relates the structure and function of these interesting receptors to how the D1 receptors may interact with human neurological and psychiatric diseases. The peripheral
Cindy P. Lawler +4 more
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American Journal of Psychiatry, 2001
OBJECTIVE The role of dopamine in the addictive process (loss of control and compulsive drug intake) is poorly understood. A consistent finding in drug-addicted subjects is a lower level of dopamine D2 receptors.
N. Volkow +12 more
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OBJECTIVE The role of dopamine in the addictive process (loss of control and compulsive drug intake) is poorly understood. A consistent finding in drug-addicted subjects is a lower level of dopamine D2 receptors.
N. Volkow +12 more
semanticscholar +1 more source
Receptor reserve at striatal dopamine receptors modulating the release of [3H]dopamine
European Journal of Pharmacology, 1988Electrically stimulated release of [3H]dopamine [( 3H]DA) in slices of rat striatum was dose dependently inhibited by apomorphine (67% maximal inhibition) with an EC50 of 17 nM. DA receptor inactivation with N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ; 0.5 and 2 mg/kg) dose dependently shifted the ED50 for apomorphine to the right and reduced ...
Hideyasu Yokoo +2 more
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1997
Table of Contents Preface Historical Overview: Introduction to the Dopamine Receptors Philip Seeman Gene and Promoter Structures of the Dopamine Receptors Ursula M. D'Souza Structural Basis of Dopamine Receptor Activation Irina S. Moreira, Lei Shi, Zachary Freyberg, Spencer S. Eriksen, Harel Weinstein, and Johnathan A. Javitch Dopamine Receptor Subtype-
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Table of Contents Preface Historical Overview: Introduction to the Dopamine Receptors Philip Seeman Gene and Promoter Structures of the Dopamine Receptors Ursula M. D'Souza Structural Basis of Dopamine Receptor Activation Irina S. Moreira, Lei Shi, Zachary Freyberg, Spencer S. Eriksen, Harel Weinstein, and Johnathan A. Javitch Dopamine Receptor Subtype-
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Caffeine mimics dopamine receptor agonists without stimulation of dopamine receptors
Neuropharmacology, 1986The purpose of this study was to examine whether caffeine stimulates dopamine (DA) receptors. The effects of caffeine on the binding of [3H]spiperone to membranes from the striatum, accumulation of L-DOPA in the striatum in mice receiving gamma-butyrolactone, and regional levels of 3,4-dihydroxyphenylacetic acid in the brain of the rat were ...
H. Watanabe, H. Uramoto
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Dopamine D2 receptors in discrimination learning and spine enlargement
Nature, 2020Y. Iino +6 more
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Dopamine and dopamine receptor agonists in cardiovascular therapy
Critical Care Medicine, 1990Dopamine (DA)--previously regarded simply as the precursor of norepinephrine--is now known to have its own unique effects on cardiovascular regulation which are mediated, in part, by activating specific DA receptors. DA has long been used in the treatment of shock and heart failure.
Michael B. Murphy, William J. Elliott
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Dopamine Receptor Oligomerization
2009Each dopamine (DA) receptor subtype physically interacts with its own kind (homomers) or other receptors (heteromers) in the plasma membrane of neurons in the basal ganglia to form dimeric or high-order receptor oligomers, termed dimeric or high-order receptor mosaics (RMs).
Fuxe K +4 more
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