Results 111 to 120 of about 6,763,423 (338)
iScience, 2020 Summary: Compared with conventional chemotherapy and radiotherapy, targeted molecular therapy, e.g., antibody-drug conjugates or aptamer-drug conjugates, can specifically identify overexpressed natural receptors on the cancer cell, perform targeted ...
Hoda Safari Yazd +9 more
doaj
Hallucinogens: mechanisms and medical complications [PDF]
, 2013 Thesis (M.A.)--Boston UniversityHallucinogens are drugs that alter consciousness by distorting primarily auditory and visual perception but they can affect any sensory system. Hallucinogens also affect judgment, orientation, memory, or emotion.
Chan, Ryan Harry Alexander
core +1 more source
Hypothesis of Rfmra Development – the Receptor-focused Magnetic and Resonant Anesthesia [PDF]
, 2016 This article is described the hypothesis of the solution how to create the "ideal anesthesia". Theoretical justification of the innovative technique of the Receptor-focused Magnetic Resonance anesthesia is offered. It should be use the "ideal anesthetic"
Golyanishchev, M. (Maxim)
core +2 more sources
STRUCTURE OF THE D2 DOPAMINE RECEPTOR BOUND TO THE ATYPICAL ANTIPSYCHOTIC DRUG RISPERIDONE
Nature, 2018 Dopamine is a neurotransmitter that has been implicated in processes as diverse as reward, addiction, control of coordinated movement, metabolism and hormonal secretion.
Sheng Wang +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti +10 more
wiley +1 more source
Elucidating Signal Transduction Modulatory Drug Target Network of Colon Cancer: A Network Biology Approach [PDF]
, 2010 Latest evaluation and validation of cancer drugs and their targets has demonstrated the lack and inadequate development of new and better drugs, based on available protocols.
Biplab Bhattacharjee +5 more
core +1 more source
Selective disruption of stimulus-reward learning in glutamate receptor gria 1 knockout mice. [PDF]
, 2003 Glutamatergic neurotransmission via AMPA receptors has been an important focus of studies investigating neuronal plasticity. AMPA receptor glutamate receptor 1 (GluR1) subunits play a critical role in long-term potentiation (LTP).
Mead, Andy N, Stephens, David N
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Adenosine receptors as drug targets [PDF]
Experimental Cell Research, 2010 There are four adenosine receptors, A(1), A(2A), A(2B) and A(3), together forming a defined subgroup of G protein coupled receptors. They are well conserved and widely expressed. The endogenous agonist, adenosine, has a minimal concentration in body fluids (20-200 nM) that is sufficient to slightly activate the receptors where they are very highly ...
openaire +3 more sources
Application of hyaluronic acid as carriers in drug delivery
Drug Delivery, 2018 Hyaluronic acid has good biocompatibility, biodegradability, and nonimmunogenicity. In addition, it has the ability to recognize specific receptors that are overexpressed on the surface of tumor cells, and cancer drugs can be targeted to the tumor cells ...
G. Huang, Hualiang Huang
semanticscholar +1 more source
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source