Results 261 to 270 of about 2,998,144 (312)

Challenges for receptor theory as a tool for drug and drug receptor classification

Trends in Pharmacological Sciences, 1989
Increased understanding in the field of receptor pharmacology, born of the sophisticated techniques now available to us, has confounded rather than simplified the problem of receptor classification. The International Union of Pharmacology (IUPHAR) is currently sponsoring a Receptor Nomenclature Committee whose aims are to recommend a rational system of
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Interaction of muscarinic drugs with their receptor

General Pharmacology: The Vascular System, 1985
Interaction of muscarinic drugs with their receptor was studied in the logitudinal muscle of guinea pig ileum. The pD2-value, the index for agonistic activity of a partial agonist was practically equal to its pA2-value, the index for competitive antagonistic activity and to its pKA-value which was a negative logarithm of a dissociation constant (KA ...
I, Takayanagi, K, Okumura, K, Koike
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Immunophilin Receptors for Immunosuppressive Drugs

Therapeutic Drug Monitoring, 1993
The major immunophilins that bind cyclosporine (cyclophilin) and FK-506/rapamycin (FK-BP 12) have been well characterized. They possess rotamase activity, which is inhibited by the immunosuppressant that binds to them. The immunosuppressive action does not appear to be coupled to rotamase activity. The literature is reviewed on some possible mechanisms
S J, Soldin, J N, Murthy, J G, Donnelly, Y, Chen, N, Goodyear   +4 more
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The emergence of the drug receptor theory

Nature Reviews Drug Discovery, 2002
Today, the concept of specific receptors for drugs and transmitters lies at the very heart of pharmacology. Less than one hundred years ago, this novel idea met with considerable resistance in the scientific community. To mark the 150th anniversary of the birth of John Newport Langley, one of the founders of the receptor concept, we highlight his most ...
Andreas-Holger, Maehle, Cay-Rüdiger, Prüll, Robert F, Halliwell   +2 more
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Drugs affecting serotonin receptors

Baillière's Clinical Gastroenterology, 1994
A greater understanding of the various serotonin receptor subtypes has led to a clearer appreciation of the role of serotonin in gastrointestinal motility, sensation and secretion. Serotonin is definitely involved in the aetiopathogenesis of cisplatin-induced emesis and carcinoid diarrhoea. The application of serotonergic drugs in clinical therapeutics
M, Camilleri, M R, Von der Ohe
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Photoproteins as models of drug receptors

Life Sciences, 1978
Abstract The calcium-sensitive photoprotein aequorin has properties that make it well suited for studies of protein-ligand interactions. Its behavior resembles that of classical drug receptors in many ways. A two-state model reproduces many of the properties of aequorin, including two that are not consistent with the conventional occupancy model.
J R, Blinks, D G, Allen, F G, Prendergast, G C, Harrer   +3 more
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Angiotensin receptor blockers and drug–drug interactions

Expert Opinion on Drug Safety, 2005
The pharmacokinetic characteristics of the angiotensin receptor blocker class are such that significant drug-drug interactions are unlikely. Moreover, this drug class is devoid of relevant class-specific side effects. These features provide some of the basis for the excellent tolerance of drugs in this class.
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The classification of drugs and drug receptors in isolated tissues.

Pharmacological Reviews, 1984
The major premise of this review is that isolated more effective therapeutic agents for man. In this contissues can be used efıctively to obtain information text, the bias of this paper will be pharmacological in about drugs and drug receptors which transcends species that receptors will be used to gain information about and function. This information,
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Receptors, Neurotransmitters and Drug Responses

New England Journal of Medicine, 1979
ABNORMALITIES in sensitivity to endogenous hormones and neurotransmitters as well as to exogenous drugs pervade clinical medicine.
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Nuclear receptor drug discovery

Current Opinion in Chemical Biology, 2008
Nuclear receptors (NR) are ligand-activated transcription factors that regulate the activation of a variety of important target genes. There are 48 genes that encode NRs in the human genome, and these receptors now represent one of the most important targets for therapeutic drug development.
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