Results 251 to 260 of about 1,154,493 (312)
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Gastrointestinal Drug Receptors
Journal of Clinical Gastroenterology, 1983Drug receptors consist of recognition sites coupled to transducer and cellular amplifier mechanisms. Slight differences in receptor recognition sites can be exploited pharmacologically to provide drugs with a high degree of selectivity for activating or blocking individual receptor subtypes.
T F, Burks, J J, Galligan, F, Porreca
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Drugs affecting serotonin receptors
Baillière's Clinical Gastroenterology, 1994A greater understanding of the various serotonin receptor subtypes has led to a clearer appreciation of the role of serotonin in gastrointestinal motility, sensation and secretion. Serotonin is definitely involved in the aetiopathogenesis of cisplatin-induced emesis and carcinoid diarrhoea. The application of serotonergic drugs in clinical therapeutics
M, Camilleri, M R, Von der Ohe
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Current Protocols in Pharmacology, 2006
AbstractReceptors, located on both the cell surface and within the cell, are the molecular targets through which drugs produce their beneficial effects in various disease states. Receptors were initially conceptualized at the beginning of the 20th century by the parallel efforts of Ehrlich and Langley.
Michael, Williams, Rita, Raddatz
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AbstractReceptors, located on both the cell surface and within the cell, are the molecular targets through which drugs produce their beneficial effects in various disease states. Receptors were initially conceptualized at the beginning of the 20th century by the parallel efforts of Ehrlich and Langley.
Michael, Williams, Rita, Raddatz
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1978
It is commonly accepted today that drugs, hormones, or other small molecules that gain access to biological systems bring about their effects by interacting with macromolecules present in the biological system. These macromolecules can then be assigned the term “receptor” for that particular small molecule.
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It is commonly accepted today that drugs, hormones, or other small molecules that gain access to biological systems bring about their effects by interacting with macromolecules present in the biological system. These macromolecules can then be assigned the term “receptor” for that particular small molecule.
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Glycine Receptor Drug Discovery
2017Postsynaptic glycine receptor (GlyR) chloride channels mediate inhibitory neurotransmission in the spinal cord and brain stem, although presynaptic and extrasynaptic GlyRs are expressed more widely throughout the brain. In humans, GlyRs are assembled as homo- or heteromeric pentamers of α1-3 and β subunits. GlyR malfunctions have been linked to a range
Lynch, Joseph W. +3 more
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Nuclear receptor drug discovery
Current Opinion in Chemical Biology, 2008Nuclear receptors (NR) are ligand-activated transcription factors that regulate the activation of a variety of important target genes. There are 48 genes that encode NRs in the human genome, and these receptors now represent one of the most important targets for therapeutic drug development.
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Receptor-mediated inotropic drugs
European Heart Journal, 1988Cardiac inotropic activity can be triggered by beta 1-, beta 2- and alpha 1-adrenoreceptors in the heart when stimulated with appropriate agonists. Dopaminergic receptor agonists have little influence on contractile force but the peripheral vasodilatation, improved renal perfusion and enhanced natriuresis mediated by dopaminergic receptor stimulation ...
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