Results 291 to 300 of about 6,763,423 (338)
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Rational understanding of nicotinic receptors drug binding.
Current Topics in Medicinal Chemistry, 2004The atomic determination of the acetylcholine binding protein (AChBP), a molluscan cholinergic protein, homologous to the amino-terminal extracellular domain of nicotinic receptors (nAChRs), offers opportunities for the modeling of the acetylcholine ...
T. Grutter +2 more
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Current Protocols in Pharmacology, 2006
AbstractReceptors, located on both the cell surface and within the cell, are the molecular targets through which drugs produce their beneficial effects in various disease states. Receptors were initially conceptualized at the beginning of the 20th century by the parallel efforts of Ehrlich and Langley.
Michael Williams, Rita Raddatz
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AbstractReceptors, located on both the cell surface and within the cell, are the molecular targets through which drugs produce their beneficial effects in various disease states. Receptors were initially conceptualized at the beginning of the 20th century by the parallel efforts of Ehrlich and Langley.
Michael Williams, Rita Raddatz
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, 1993
The highest structural diversity of GABAA-receptor subunits is observed among members of the α-subunit class. Using subunit-specific antisera, the receptors containing the α2-subunit were characterized.
R. Marksitzer +5 more
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The highest structural diversity of GABAA-receptor subunits is observed among members of the α-subunit class. Using subunit-specific antisera, the receptors containing the α2-subunit were characterized.
R. Marksitzer +5 more
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The emergence of the drug receptor theory [PDF]
Nature Reviews Drug Discovery, 2002 Today, the concept of specific receptors for drugs and transmitters lies at the very heart of pharmacology. Less than one hundred years ago, this novel idea met with considerable resistance in the scientific community. To mark the 150th anniversary of the birth of John Newport Langley, one of the founders of the receptor concept, we highlight his most ...
Andreas-Holger Maehle +2 more
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Drug Receptors and their Function
Nature, 1971There have been various theories about the way in which drugs exert their effects. If recent progress in the isolation of receptors continues, it should soon be possible to look directly at the interaction between drugs and tissues.
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2020
Conventional treatment of any disease can be achieved by the administration of drugs of natural and synthetic origin. The drug exhibits its pharmacological action by altering cellular signaling or the biochemical events associated with the respective target proteins such as receptors or enzymes.
Haneen Al-Joubi +10 more
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Conventional treatment of any disease can be achieved by the administration of drugs of natural and synthetic origin. The drug exhibits its pharmacological action by altering cellular signaling or the biochemical events associated with the respective target proteins such as receptors or enzymes.
Haneen Al-Joubi +10 more
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1978
It is commonly accepted today that drugs, hormones, or other small molecules that gain access to biological systems bring about their effects by interacting with macromolecules present in the biological system. These macromolecules can then be assigned the term “receptor” for that particular small molecule.
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It is commonly accepted today that drugs, hormones, or other small molecules that gain access to biological systems bring about their effects by interacting with macromolecules present in the biological system. These macromolecules can then be assigned the term “receptor” for that particular small molecule.
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Challenges for receptor theory as a tool for drug and drug receptor classification
Trends in Pharmacological Sciences, 1989Increased understanding in the field of receptor pharmacology, born of the sophisticated techniques now available to us, has confounded rather than simplified the problem of receptor classification. The International Union of Pharmacology (IUPHAR) is currently sponsoring a Receptor Nomenclature Committee whose aims are to recommend a rational system of
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Drugs affecting serotonin receptors
Baillière's Clinical Gastroenterology, 1994A greater understanding of the various serotonin receptor subtypes has led to a clearer appreciation of the role of serotonin in gastrointestinal motility, sensation and secretion. Serotonin is definitely involved in the aetiopathogenesis of cisplatin-induced emesis and carcinoid diarrhoea. The application of serotonergic drugs in clinical therapeutics
Manfred R. Von Der Ohe +1 more
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Pharmacology and functions of metabotropic glutamate receptors.
Annual Review of Pharmacology and Toxicology, 1997In the mid to late 1980s, studies were published that provided the first evidence for the existence of glutamate receptors that are not ligand-gated cation channels but are coupled to effector systems through GTP-binding proteins.
Conn Pj, J. Pin
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