Results 301 to 310 of about 6,763,423 (338)
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Immunophilin Receptors for Immunosuppressive Drugs
Therapeutic Drug Monitoring, 1993The major immunophilins that bind cyclosporine (cyclophilin) and FK-506/rapamycin (FK-BP 12) have been well characterized. They possess rotamase activity, which is inhibited by the immunosuppressant that binds to them. The immunosuppressive action does not appear to be coupled to rotamase activity. The literature is reviewed on some possible mechanisms
Yajun Chen +4 more
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Interaction of muscarinic drugs with their receptor
General Pharmacology: The Vascular System, 1985Interaction of muscarinic drugs with their receptor was studied in the logitudinal muscle of guinea pig ileum. The pD2-value, the index for agonistic activity of a partial agonist was practically equal to its pA2-value, the index for competitive antagonistic activity and to its pKA-value which was a negative logarithm of a dissociation constant (KA ...
Issei Takayanagi +2 more
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1965
Publisher Summary This chapter reviews that the concept of a receptor proves to be remarkably elusive, considering the central position it occupies in the theory of pharmacology. A receptor is considered as the component of a cell with which a drug combines to initiate a response. It is suggested that the receptor has a complementary structure to the
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Publisher Summary This chapter reviews that the concept of a receptor proves to be remarkably elusive, considering the central position it occupies in the theory of pharmacology. A receptor is considered as the component of a cell with which a drug combines to initiate a response. It is suggested that the receptor has a complementary structure to the
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Drug interactions at GABAA receptors
Progress in Neurobiology, 2002Neurotransmitter receptor systems have been the focus of intensive pharmacological research for more than 20 years for basic and applied scientific reasons, but only recently has there been a better understanding of their key features. One of these systems includes the type A receptor for the gamma-aminobutyric acid (GABA), which forms an integral ...
Esa R. Korpi +2 more
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2006
This chapter discusses the various mathematical models used to describe and quantify drug response. This begins with consideration of the classical theory which formed the basis of all subsequent models followed by the model of agonism most prevalent in pharmacology at this time, the Black/Leff operational model.
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This chapter discusses the various mathematical models used to describe and quantify drug response. This begins with consideration of the classical theory which formed the basis of all subsequent models followed by the model of agonism most prevalent in pharmacology at this time, the Black/Leff operational model.
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Angiotensin receptor blockers and drug–drug interactions
Expert Opinion on Drug Safety, 2005The pharmacokinetic characteristics of the angiotensin receptor blocker class are such that significant drug-drug interactions are unlikely. Moreover, this drug class is devoid of relevant class-specific side effects. These features provide some of the basis for the excellent tolerance of drugs in this class.
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Nuclear receptor drug discovery
Current Opinion in Chemical Biology, 2008Nuclear receptors (NR) are ligand-activated transcription factors that regulate the activation of a variety of important target genes. There are 48 genes that encode NRs in the human genome, and these receptors now represent one of the most important targets for therapeutic drug development.
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Receptors, Neurotransmitters and Drug Responses
New England Journal of Medicine, 1979ABNORMALITIES in sensitivity to endogenous hormones and neurotransmitters as well as to exogenous drugs pervade clinical medicine.
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Glycine Receptor Drug Discovery
2017Postsynaptic glycine receptor (GlyR) chloride channels mediate inhibitory neurotransmission in the spinal cord and brain stem, although presynaptic and extrasynaptic GlyRs are expressed more widely throughout the brain. In humans, GlyRs are assembled as homo- or heteromeric pentamers of α1-3 and β subunits. GlyR malfunctions have been linked to a range
Lynch, Joseph W. +3 more
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The classification of drugs and drug receptors in isolated tissues.
Pharmacological Reviews, 1984The major premise of this review is that isolated more effective therapeutic agents for man. In this contissues can be used efıctively to obtain information text, the bias of this paper will be pharmacological in about drugs and drug receptors which transcends species that receptors will be used to gain information about and function. This information,
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