Results 221 to 230 of about 43,204 (252)
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Role of FSH and FSH receptor on HUVECs migration
Gene Therapy, 2020Follicle-stimulating hormone (FSH) is a pituitary glycoprotein that regulates follicle maturation through its binding to follicle-stimulating hormone receptor (FSHR). Endothelial cells express FSHR, but its exact role in endothelial cells remains unclear. Here we show that FSHR expression was detectable in human umbilical vein endothelial cells (HUVECs)
Dailin Tan +3 more
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Mutations of LH and FSH receptors
Journal of Endocrinological Investigation, 2000Gonadotropins control male and female gonadal function by acting through specific receptors. The recent description of several mutations in LH and FSH receptors has significantly improved our understanding of the pathophysiology of several sexual disorder. Both gain- and loss-of-function germline mutations leading to constitutive receptor activation or
P, Beck-Peccoz, R, Romoli, L, Persani
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Primate FSH-receptor promoter nucleotide sequence heterogeneity affects FSH-receptor transcription
Molecular and Cellular Endocrinology, 2010Follicle-stimulating hormone (FSH) is essential for primate reproduction and acts via the FSH-receptor (FSHR). Although the FSHR expression is highly cell-specific, knowledge of the FSHR promoter and its transcriptional regulation is very limited. We applied a comparative genomic approach of important primate lineages to characterize the FSHR core ...
Maik, Brune +2 more
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RADIOLIGAND RECEPTOR ASSAY OF FSH
Acta Endocrinologica, 1976ABSTRACT The assay of FSH by a radioligand receptor assay (RLA) using homogenates of rat testicular tissue incubated for 17 h at 21°C has been assessed. Chloramine-T or lactoperoxidase were used for iodination. The assay gave linear dose-response lines between 30 and 2000 ng sheep FSH/tube, and there was usually no major interference by LH. Two batches
P S, Brown +3 more
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Polymorphism of the FSH receptor and ovarian response to FSH
Annales d'Endocrinologie, 2007Follicle-stimulating hormone (FSH) is a key factor in human reproduction. FSH activates its receptor (FSHR) located exclusively on Sertoli cells in the testis and granulosa cells in the ovary. Two common single nucleotide polymorphisms (SNP) within exon 10 of the human FSHR gene result in two almost equally common allelic variants exhibiting threonine (
WUNSCH A, SONNTAG B, SIMONI, Manuela
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Genetic complexity of FSH receptor function
Trends in Endocrinology & Metabolism, 2005The interaction between follicle-stimulating hormone (FSH) and the FSH receptor (FSHR) is essential for normal oogenesis and spermatogenesis. Recently, single-nucleotide polymorphisms (SNPs) have been assigned to the FSHR gene. These give rise to different FSHR haplotypes that modify the action of FSH.
GROMOLL J, SIMONI, Manuela
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Chemical Biology & Drug Design, 2009
Follicle‐stimulating hormone (FSH) receptor binding inhibitor (FRBI‐8) is a novel octapeptide purified from human ovarian follicular fluid. In vitro, it inhibits the binding of FSH to granulosa cells and in vivo, it induces atresia in developing follicles in rodents.
Swati S, Chitnis +6 more
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Follicle‐stimulating hormone (FSH) receptor binding inhibitor (FRBI‐8) is a novel octapeptide purified from human ovarian follicular fluid. In vitro, it inhibits the binding of FSH to granulosa cells and in vivo, it induces atresia in developing follicles in rodents.
Swati S, Chitnis +6 more
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FSH receptors in the bovine corpus luteum
Theriogenology, 1984Binding of follicle stimulating hormone (FSH) to a crude membrane fraction of bovine corpus luteum (CL) has been detected. This binding meets the usual criteria for a receptor based on specificity, time course of reaction and association constant (Ka = 8.5 x 10(10)M(-1)). Physiological studies with CL removed from heifers at specific times after estrus
J G, Manns, G D, Niswender, T, Braden
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The molecular biology of the FSH receptor
The Journal of Steroid Biochemistry and Molecular Biology, 1995The actions of follicle stimulating hormone (FSH) mediated through its receptor are necessary for the proper functioning of mammalian gonads. The FSH receptor is localized on granulosa cells of the ovary and Sertoli cells of the testis. The expression of the FSH receptor (FSHR) in Sertoli cells varies in vivo as a function of the stage of the cycle of ...
M D, Griswold, L, Heckert, C, Linder
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