Results 231 to 240 of about 43,204 (252)

Inactivating FSH receptor mutations and gonadal dysfunction

Molecular and Cellular Endocrinology, 1998
A variety of mutations and polymorphisms of genes regulating female and male reproductive functions have been discovered during the last few years. These include several inactivating and activating mutations in LH receptor genes. The first mutation of FSH receptor (FSHR) gene was discovered in six Finnish families.
J S, Tapanainen, T, Vaskivuo, K, Aittomäki, I T, Huhtaniemi   +3 more
openaire   +2 more sources

Fish FSH receptors bind LH: How to make the human FSH receptor to be more fishy?

General and Comparative Endocrinology, 2005
In mammals, the interactions between glycoprotein hormones and their cognate receptors are highly specific; unintended cross-reactivity under normal physiological conditions has not been observed. The interactions between fish gonadotropins and their receptors, on the other hand, appeared to be less discriminatory.
Bogerd, J., Granneman, J.C.M., Schulz, R.W., Vischer, H.F.   +3 more
openaire   +3 more sources

Two receptor binding regions of human FSH show sense-antisense similarity to the human FSH receptor

Biochemical and Biophysical Research Communications, 1991
The sequences of two receptor binding regions of the beta-subunit of the human follicle-stimulating hormone (hFSH-beta) were compared with the DNA-derived antisense peptide sequence of the hFSH receptor. A striking sense-antisense similarity was established between these receptor binding regions and the hFSH receptor.
J W, Slootstra, E W, Roubos
openaire   +2 more sources

Expression of FSH and its co-localization with FSH receptor and GnRH receptor in rat cerebellar cortex

Journal of Molecular Histology, 2012
The expression of follicle-stimulating hormone (FSH) and its receptor in extrapituitary and non-HPG axis tissues has been demonstrated and their non-reproductive functions in these tissues have been found. However, there have been no reports concerning the expression and function of FSH and its receptor in the cerebellum.
Chenyu, Chu, Jing'an, Zhou, Yaqun, Zhao, Ce, Liu, Pengfei, Chang, Qing, Zhou, Li, Zhao, Weiquan, Huang   +7 more
openaire   +2 more sources

Cloning and sequencing of human FSH receptor cDNA

Biochemical and Biophysical Research Communications, 1991
We have isolated and sequenced a cDNA encoding the follicle stimulating hormone (FSH) receptor. The deduced amino acid sequence (678 residues) containing seven putative transmembrane segments which displays sequence similarity to G protein-coupled receptors.
T, Minegishi, K, Nakamura, Y, Takakura, Y, Ibuki, M, Igarashi, T ], Minegish T [corrected to Minegishi   +5 more
openaire   +2 more sources

Regulation of the FSH Receptor in the Ovary

Trends in Endocrinology & Metabolism, 1999
The follicle-stimulating hormone receptor (FSHR) is found exclusively on granulosa cells from as early as the two-layer or primary stage of folliculogenesis. Up to four alternatively spliced transcripts have been described. An increase in steady-state levels of FSHR mRNA as well as a change in alternative splicing appear to be important during early ...
, Findlay, , Drummond
openaire   +2 more sources

Abnormality of testicular FSH receptors in infertile men

Acta Endocrinologica, 1984
Abstract. To ascertain whether abnormalities in testicular binding of follicle stimulating hormone (FSH) are related with spermatogenic impairment found in idiopathic male infertility, we measured FSH receptors in testicular tissues obtained by biopsy from 37 infertile men.
M, Namiki, T, Koide, A, Okuyama, T, Sonoda, H, Itatani, A, Miyake, T, Aono, N, Terada, K, Matsumoto   +8 more
openaire   +2 more sources

Fish FSH receptors bind LH

General and Comparative Endocrinology, 2005
In mammals, the interactions between glycoprotein hormones and their cognate receptors are highly specific; unintended cross-reactivity under normal physiological conditions has not been observed. The interactions between fish gonadotropins and their receptors, on the other hand, appeared to be less discriminatory.
Bogerd, Jan, Granneman, Joke C M, Schulz, Rüdiger W, Vischer, Henry F   +3 more
openaire   +1 more source

Functional expression of the recombinant human FSH receptor

Journal of Endocrinology, 1994
Abstract The functional capacity of the recombinant human FSH (hFSH) receptor was tested on the basis of gonadotrophin stimulation of cyclic AMP (cAMP) production by transient transfections of 293 cells and stable transfections of Chinese hamster ovary (CHO) cells.
T, Minegishi, S, Igarashi, K, Nakamura, M, Nakamura, M, Tano, H, Shinozaki, K, Miyamoto, Y, Ibuki   +7 more
openaire   +2 more sources

Pharmacogenetics of G-protein-coupled receptors variants: FSH receptor and infertility treatment

Best Practice & Research Clinical Endocrinology & Metabolism, 2018
Infertility treatment may represent a paradigmatic example of precision medicine. Follicle-stimulating hormone (FSH) has been proposed as a valuable therapeutic option both in males and in females, even if a standardized approach is far to be established.
Santi, Daniele, Potì, Francesco, Simoni, Manuela, Casarini, Livio   +3 more
openaire   +3 more sources