Results 91 to 100 of about 60,411 (297)

The structure and function of taste G protein-coupled receptors and their implications in diseases

International Journal of Oral Science
Taste G protein-coupled receptors (GPCRs), including sweet (TAS1Rs) and bitter (TAS2Rs) taste receptors, are essential for detecting nutrients and avoiding toxins, influencing dietary behavior, metabolism, and overall health.
Ruohan Zhai, Xihao Yong, Peihua Jiang, Marco Tizzano, Zhenhua Shao, Wei Yan, Xin Zheng   +6 more
doaj   +1 more source

Metabolic Regulation by the Hypothalamic Neuropeptide, Gonadotropin-Inhibitory Hormone at Both the Central and Peripheral Levels

Cells
Gonadotropin-inhibitory hormone (GnIH) is well-established as a negative regulator of reproductive physiology and behavior across vertebrates, acting on the hypothalamic–pituitary–gonadal (HPG) axis; however, recent data have also demonstrated its ...
You Lee Son, Simone L. Meddle, Yasuko Tobari   +2 more
doaj   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

New synthetic bile acid analogue agonists of FXR and TGR5 receptors: Analytical methodologies for the study of their physico-chemical properties, pharmacokinetic activity and metabolism. [PDF]

, 2013
This thesis reports an integrated analytical approach for the study of physicochemical and biological properties of new synthetic bile acid (BA) analogues agonists of FXR and TGR5 receptors.
Colliva, Carolina <1981>
core   +1 more source

Insulin-like Growth Factors (IGFs) and their binding proteins (IGFBPs) as biomarkers of catabolism [PDF]

Journal of Medical Biochemistry, 2007
The life of an organism depends on its capacity to maintain equilibrium Disease induces acute adaptive responses specific to the stimulus and the organism achieves stability through change.
Nedić Olgica, Nikolić-Judith Anna, Malenković Vesna, Baričević-Jones Ivona   +3 more
doaj  

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Simultaneous non-negative matrix factorization for multiple large scale gene expression datasets in toxicology [PDF]

, 2012
Non-negative matrix factorization is a useful tool for reducing the dimension of large datasets. This work considers simultaneous non-negative matrix factorization of multiple sources of data.
Clare M. Lee, Vass J. Keith, D R Haggart, Lee Clare M., Mudaliar, MAV, Higham, Desmond, Vass, D.J., Manikhandan A V Mudaliar, Gino Miele, Mudaliar, Manikhandan A.V., Haggart, D. R., Mudaliar, M.A.V., Higham, Desmond J., Haggart D. R., Crowther, Daniel, D. R. Haggart, Lee, C.M., Lee, Clare M., Mudaliar Manikhandan A. V., J Keith Vass, Higham Desmond J., Wolf, C.R., Higham, D.J., Wolf C. Roland, Miele Gino, Mudaliar, Manikhandan A. V., Miele, Geno, Desmond J Higham, Clare M Lee, C. Roland Wolf, Miele, G., Manikhandan A. V. Mudaliar, C Roland Wolf, Crowther Daniel, Vass, J.K., Miele, Gino, J. Keith Vass, Crowther, D., Crowther, Daniel; id_orcid, Daniel Crowther, Vass, J. Keith, Desmond J. Higham, Haggart, D.R., Wolf, C. Roland, Lee, Clare   +44 more
core   +1 more source

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

Functional engineering of human iPSC‐derived parasympathetic neurons enhances responsiveness to gastrointestinal hormones

FEBS Open Bio
Food‐derived biological signals are transmitted to the brain via peripheral nerves through the paracrine activity of gastrointestinal (GI) hormones. The signal transduction circuit of the brain–gut axis has been analyzed in animals; however, species ...
Yuka Akagi, Yuzo Takayama, Yuma Nihashi, Azusa Yamashita, Risa Yoshida, Yasuhisa Miyamoto, Yasuyuki S. Kida   +6 more
doaj   +1 more source

Biomarkers of Sarcopenia: Current Status and Future Perspectives

AGING MEDICINE, EarlyView.
In this review, we summarize the various biomarkers discovered in recent years, including biochemical, imaging, and physical testing markers. We analyze their advantages and disadvantages and propose potential ways to improve the diagnostic accuracy of biomarkers, as well as future research directions.
Bijin Luo, Wenhan Li, Yi Zhang, Mengchen Liu, Kemeng Zhang, Sui Huang, Ping He   +6 more
wiley   +1 more source