Results 251 to 260 of about 92,907 (309)
IgE Nonresponders in Basophil Activation Tests: A Narrative Review From Mechanistic Insights to Clinical Implications and Future Directions. [PDF]
J Immunol ResEberlein B, Biedermann T.
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From neuroimmune circuits to targeted therapy of chronic pruritus. [PDF]
Pharmacol RevRamcke T, Kaplan DH.
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Unravelling the Intricate Link: Mast Cells and Estrogen-Induced Pain Sensitization in Endometriosis. [PDF]
Int J Biol SciWang J, Mao X, Zhu L, Zhang X.
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Current Protocols in Pharmacology, 2001
AbstractThis unit describes three standard in vitro bioassays for studying histamine H1, H2 and H3 receptors in isolated intact tissues removed from the guinea pig. Both the H1 and H3 receptor assays are based on preparations of the ileum, whereas the spontaneously beating right atrium assay is used for the H2‐receptor.This unit describes three ...
N P, Shankley, M F, Morton, G F, Watt
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AbstractThis unit describes three standard in vitro bioassays for studying histamine H1, H2 and H3 receptors in isolated intact tissues removed from the guinea pig. Both the H1 and H3 receptor assays are based on preparations of the ileum, whereas the spontaneously beating right atrium assay is used for the H2‐receptor.This unit describes three ...
N P, Shankley, M F, Morton, G F, Watt
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Histamine H3 Receptor Agonists
Mini-Reviews in Medicinal Chemistry, 2004The SAR of H3 ligands has been difficult to evaluate because of species differences, multiple isoforms and constitutive activity, among other complicating factors. A review is given of the sometimes-conflicting affinity, activity and efficacy data of H3 agonists that has been described in literature to date.
I J P, De Esch, K J, Belzar
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Histamine H4 receptor agonists
Bioorganic & Medicinal Chemistry Letters, 2010Since its discovery 10 years ago the histamine H(4) receptor (H(4)R) has attracted attention as a potential drug target, for instance, for the treatment of inflammatory and allergic diseases. Potent and selective ligands including agonists are required as pharmacological tools to study the role of the H(4)R in vitro and in vivo.
Patrick, Igel +2 more
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2002
Abstract Histamine [2-(4-imidazolyl)ethylamine, HA] is an endogenous biogenic amine synthesized in and released from several kinds of cells, and involved in many kinds of biological signalling (Uvnas 1991). Mast cells (a family of bone marrow-derived secretory cells) store much of the body’s HA in very high concentrations.
Lindsay B Hough, Rob Leurs
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Abstract Histamine [2-(4-imidazolyl)ethylamine, HA] is an endogenous biogenic amine synthesized in and released from several kinds of cells, and involved in many kinds of biological signalling (Uvnas 1991). Mast cells (a family of bone marrow-derived secretory cells) store much of the body’s HA in very high concentrations.
Lindsay B Hough, Rob Leurs
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Histamine and Histamine Receptor Antagonists in Cancer Biology
Inflammation & Allergy - Drug Targets, 2010Histamine has been demonstrated to be involved in cell proliferation, embryonic development, and tumour growth. These various biological effects are mediated through the activation of specific histamine receptors (H1, H2, H3, and H4) that differ in their tissue expression patterns and functions.
Bruno, Blaya +8 more
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Histamine H3-receptor isoforms
Inflammation Research, 2004Increasing evidence supports a role for HA as a neurotransmitter and neuromodulator in various brain functions, including emotion, cognition, and feeding. The recent cloning of the histamine H3 receptor allowed for the subsequent cloning of a variety of H3 receptor isoforms from different species as well as the H4 receptor.
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