Results 1 to 10 of about 784,733 (223)

Cross-Talk Between Histamine H₂ Receptor and Glucocorticoid Receptor: Potential Implications in Acute Myeloid Leukemia Treatment. [PDF]

Pharmacol Res Perspect
ABSTRACT This study investigates the impact of histamine H2 receptor activation on glucocorticoid receptor (GR)‐mediated transcriptional activity, as well as its effects on leukemic cell proliferation and chemotherapy resistance. We demonstrate that activation of the histamine H2 receptor by its specific agonist, amthamine, enhances GR transcriptional ...
Torralba-Agu V, Fernández N, Shayo C, Davio C, Zappia CD, Monczor F.   +5 more
europepmc   +2 more sources

Improvement of Fibromyalgia by Immunoglobulin/Histamine Complex Therapy for Chronic Urticaria and Allergic Rhinitis: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Fibromyalgia (FM) is a chronic pain syndrome characterized by widespread musculoskeletal pain, often accompanied by fatigue, sleep disturbance, and cognitive symptoms. Although several treatment options are available, no curative therapy has been established.
Kim HS, Nam Y, Sohn JE, Noh G.
europepmc   +2 more sources

Changes in Histamine Receptors (H1, H2, and H3) Expression in Rat Medial Vestibular Nucleus and Flocculus after Unilateral Labyrinthectomy: Histamine Receptors in Vestibular Compensation. [PDF]

PLoS ONE, 2013
Vestibular compensation is the process of behavioral recovery following peripheral vestibular lesion. In clinics, the histaminergic medicine is the most widely prescribed for the treatment of vertigo and motion sickness, however, the molecular mechanisms
Liuqing Zhou, Wen Zhou, Sulin Zhang, Bo Liu, Yangming Leng, Renhong Zhou, Weijia Kong   +6 more
doaj   +2 more sources

Use of Antihistamine Drugs in Colitis: A Review [PDF]

Pharmaceuticals
Background/Objectives: Colitis involves both local intestinal damage and systemic dysfunction, driven by oxidative stress and immune imbalance. Histamine, acting through its receptors, influences these processes, yet its therapeutic relevance in colitis ...
Bartosz Bogielski, Dariusz Gach, Katarzyna Michalczyk, Bronisława Skrzep-Poloczek, Mateusz Stojko, Jolanta Zalejska-Fiolka, Dominika Stygar   +6 more
doaj   +2 more sources

The Impact of H1–H4 Receptor Antagonists on the Levels of Selected Oxidative Stress Markers in Liver and Muscle Tissue in an Animal Model of Colitis [PDF]

Pharmaceuticals
Background/Objectives: The global prevalence and incidence of inflammatory bowel diseases have risen in the past two decades. Among them, Crohn’s disease and ulcerative colitis are still challenging to treat due to vascular and proliferative alterations.
Bartosz Bogielski, Katarzyna Michalczyk, Wojciech Gębski, Katarzyna Rozpędek, Elżbieta Szulińska, Bartosz Tempka, Aleksandra Zorychta, Elżbieta Chełmecka, Ewa Kaczmar, Piotr Głodek, Jakub John, Kamil Nikiel, Bronisława Skrzep-Poloczek, Jerzy Jochem, Katarzyna Kieć-Kononowicz, Dorota Łażewska, Dominika Stygar   +16 more
doaj   +2 more sources

Modulation of vestibular function and receptor expression by experimental hypergravity in a rat model [PDF]

Scientific Reports
Motion sickness develops because of a mismatch or conflict between the information gathered from the visual input, somatosensory input, and the vestibular system. Altered gravity can cause motion sickness while traveling in space. In this study, we aimed
Jin Sil Choi, Ji Eun Hong, Yoon Kun Jung, Kyu-Sung Kim, Hyun Ji Kim   +4 more
doaj   +2 more sources

The Roles of Cardiovascular H2-Histamine Receptors Under Normal and Pathophysiological Conditions

Frontiers in Pharmacology, 2021
This review addresses pharmacological, structural and functional relationships among H2-histamine receptors and H1-histamine receptors in the mammalian heart.
Joachim Neumann, Uwe Kirchhefer, Stefan Dhein, Britt Hofmann, Ulrich Gergs   +4 more
doaj   +1 more source

Histamine can be Formed and Degraded in the Human and Mouse Heart

Frontiers in Pharmacology, 2021
Histamine is metabolized by several enzymes in vitro and in vivo. The relevance of this metabolism in the mammalian heart in vivo is unclear. However, histamine can exert positive inotropic effects (PIE) and positive chronotropic effects (PCE) in humans ...
Joachim Neumann, Juliane M. Grobe, Jacqueline Weisgut, Hubert G. Schwelberger, Wieslawa Agnieszka Fogel, Margaréta Marušáková, Hartmut Wache, Heike Bähre, Igor B. Buchwalow, Stefan Dhein, Britt Hofmann, Uwe Kirchhefer, Ulrich Gergs   +12 more
doaj   +1 more source

Correlation of Histamine Receptors and Adrenergic Receptor in Broilers Appetite [PDF]

Archives of Razi Institute, 2022
The current study was conducted to investigate the interaction between the central adrenergic and histaminergic systems and the broiler chick’s feed intake.
M Daneshvar, M Zendehdel, B Vazir, A Asghari   +3 more
doaj   +1 more source

Insight into the Mode of Action of 8-Hydroxyquinoline-Based Blockers on the Histamine Receptor 2

Biosensors, 2023
Histamine receptor 2 (HRH2) blockers are used to treat peptic ulcers and gastric reflux. Chlorquinaldol and chloroxine, which contain an 8-hydroxyquinoline (8HQ) core, have recently been identified as blocking HRH2.
Amisha Patel, Paola L. Marquez-Gomez, Lily R. Torp, Lily Gao, Pamela Peralta-Yahya   +4 more
doaj   +1 more source