Ranitidine attenuates myocardial fibrosis by suppressing histamine/H2 receptor signaling and FAK/Src activation [PDF]
Frontiers in PharmacologyObjectiveMyocardial fibrosis (MF) is a pathological process often triggered by chronic inflammation and pressure overload. This study aimed to investigate the therapeutic potential of ranitidine, a histamine H2 receptor antagonist, on MF and explore its ...
Liwen Yang +9 more
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LifeHistamine receptor antagonists, which can bind to specific histamine receptors on target cells, exhibit substantial therapeutic efficacy in managing a variety of histamine-mediated disorders.
Erwen Kou +4 more
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Cross-Talk Between Histamine H<sub>2</sub> Receptor and Glucocorticoid Receptor: Potential Implications in Acute Myeloid Leukemia Treatment. [PDF]
Pharmacol Res PerspectABSTRACT This study investigates the impact of histamine H2 receptor activation on glucocorticoid receptor (GR)‐mediated transcriptional activity, as well as its effects on leukemic cell proliferation and chemotherapy resistance. We demonstrate that activation of the histamine H2 receptor by its specific agonist, amthamine, enhances GR transcriptional ...
Torralba-Agu V +5 more
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Phagocytosis by macrophages depends on histamine H2 receptor signaling and scavenger receptor 1 [PDF]
MicrobiologyOpen, 2019 The histamine H2 receptor (H2R) is a G protein‐coupled receptor that mediates cyclic AMP production, protein kinase A activation, and MAP kinase signaling.
Robert Fultz +9 more
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Histamine H2-receptor antagonists for urticaria. [PDF]
Cochrane Database Syst Rev, 2012 Urticaria is a common skin disease characterised by itching weals or hives, which can occur almost anywhere on the body. There are a number of different subtypes and a range of available treatment options. There is lack of agreement on the efficacy of H2-receptor antagonists used in the treatment of urticaria.To assess the safety and effectiveness of ...
Fedorowicz Z, van Zuuren EJ, Hu N.
europepmc +5 more sources
The Impact of H1–H4 Receptor Antagonists on the Levels of Selected Oxidative Stress Markers in Liver and Muscle Tissue in an Animal Model of Colitis [PDF]
PharmaceuticalsBackground/Objectives: The global prevalence and incidence of inflammatory bowel diseases have risen in the past two decades. Among them, Crohn’s disease and ulcerative colitis are still challenging to treat due to vascular and proliferative alterations.
Bartosz Bogielski +16 more
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Improvement of Fibromyalgia by Immunoglobulin/Histamine Complex Therapy for Chronic Urticaria and Allergic Rhinitis: A Case Report. [PDF]
Clin Case RepABSTRACT Fibromyalgia (FM) is a chronic pain syndrome characterized by widespread musculoskeletal pain, often accompanied by fatigue, sleep disturbance, and cognitive symptoms. Although several treatment options are available, no curative therapy has been established.
Kim HS, Nam Y, Sohn JE, Noh G.
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Journal of Pharmacological Sciences, 2007 Histamine is a major mediator in allergy acting mainly through the histamine H1 receptor (H1R). Although H1R up-regulation has been suggested as an important step for induction of allergic symptoms, little is known about the regulation of H1R level. Here
Asish K. Das +10 more
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RELEASE OF HISTAMINE BY H2-RECEPTOR ANTAGONISTS [PDF]
The Lancet, 1982 letter
J V, Parkin +4 more
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The Roles of Cardiovascular H2-Histamine Receptors Under Normal and Pathophysiological Conditions
Frontiers in Pharmacology, 2021 This review addresses pharmacological, structural and functional relationships among H2-histamine receptors and H1-histamine receptors in the mammalian heart.
Joachim Neumann +4 more
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