Results 1 to 10 of about 1,693 (192)

Spectrophotometric Methods for the Assay of Pyrilamine Maleate Using Chromogenic Reagents [PDF]

E-Journal of Chemistry, 2010
Simple, accurate and reproducible UV spectrophotometric methods were established for the assay of pyrilamine maleate (PYRA) based on the formation of oxidative coupling and precipitation, charge transfer complexation products.
V. Annapurna, G. Jyothi, V. Nagalakshmi, B. B. V. Sailaja   +3 more
doaj   +4 more sources

Region-independent active CNS net uptake of marketed H+/OC antiporter system substrates [PDF]

Frontiers in Cellular Neuroscience
The pyrilamine-sensitive proton-coupled organic cation (H+/OC) antiporter system facilitates the active net uptake of several marketed organic cationic drugs across the blood-brain barrier (BBB).
Frida Bällgren, Yang Hu, Shannuo Li, Lara van de Beek, Margareta Hammarlund-Udenaes, Irena Loryan   +5 more
doaj   +2 more sources

Pyrilamine in the horse: detection and pharmacokinetics of pyrilamine and its major urinary metaboliteO‐desmethylpyrilamine [PDF]

Journal of Veterinary Pharmacology and Therapeutics, 2009
Pyrilamine is an antihistamine used in human and veterinary medicine. As antihistamines produce central nervous system effects in horses, pyrilamine has the potential to affect the performance of racehorses. In the present study,O‐desmethylpyrilamine (O‐DMP) was observed to be the predominant equine urinary metabolite of pyrilamine.
L, Dirikolu, A F, Lehner, J D, Harkins, W E, Woods, W, Karpiesiuk, R S, Gates, M, Fisher, T, Tobin   +7 more
openaire   +5 more sources

Comparison of Pulmonary Accumulation of Pyrilamine and Pyrilamine N-oxide [PDF]

Japanese Journal of Pharmacology, 1985
Our previous studies have indicated that a phenothiazine drug, chlorpromazine, and a tricyclic antidepressant, imipramine, are metabolized by the isolated perfused rat lungs via N-oxidation from whence their N-oxides are released into the circulation. This work was undertaken to compare the pulmonary accumulation of another pneumophilic tertiary amine ...
OHMIYA, Yoshio, FUJISAWA, Susumu, NAKAI, Kengo   +2 more
openaire   +4 more sources

The putative proton-coupled organic cation antiporter is involved in uptake of triptans into human brain capillary endothelial cells [PDF]

Fluids and Barriers of the CNS
Background Triptans are anti-migraine drugs with a potential central site of action. However, it is not known to what extent triptans cross the blood–brain barrier (BBB).
Nana Svane, Alberte Bay Villekjær Pedersen, Anne Rodenberg, Burak Ozgür, Lasse Saaby, Christoffer Bundgaard, Mie Kristensen, Peer Tfelt-Hansen, Birger Brodin   +8 more
doaj   +2 more sources

Ameliorative Effect of a Hippocampal Metabotropic Glutamate– Receptor Agonist on Histamine H1 Receptor Antagonist–Induced Memory Deficit in Rats [PDF]

Journal of Pharmacological Sciences, 2010
This study was performed to investigate the ameliorative effects of metabotropic glutamate (mGlu)-receptor agonists on histamine H1 receptor antagonist–induced spatial memory deficit and the decrease in hippocampal theta activity in rats. Intraperitoneal
Takayoshi Masuoka, Azusa Mikami, Chiaki Kamei   +2 more
doaj   +2 more sources

Oceanapia magna Sponge Presents Dual Effect on the Gastrointestinal Motility of Rodents: In Vitro and In Vivo Assays [PDF]

Frontiers in Pharmacology, 2020
Oceanapia magna Santos-Neto, Nascimento, Cavalcanti and Pinheiro sponges are distributed across tropical worldwide seas. Some studies of marine products have shown interesting activities in smooth muscle models.
Joedna Cavalcante Pereira, Indyra Alencar Duarte Figueiredo, Filipe Rodolfo Moreira Borges de Oliveira, Sarah Rebeca Dantas Ferreira, Giulyane Targino Aires Moreno, Tania Maria Sarmento da Silva, Ulisses dos Santos Pinheiro, Barbara Viviana de Oliveira Santos, Barbara Viviana de Oliveira Santos, Bagnólia Araújo da Silva, Bagnólia Araújo da Silva, Fabiana de Andrade Cavalcante, Fabiana de Andrade Cavalcante   +12 more
doaj   +2 more sources

Comparative analysis of the uptake of the H+/OC antiporter substrate oxycodone across and into brain endothelial and parenchymal cells with in vitro–in vivo extrapolation [PDF]

Fluids and Barriers of the CNS
Background In vitro evaluation of substances utilizing the putative proton‑coupled organic cation (H+/OC) antiporter for active uptake across the blood-brain barrier (BBB) and brain cell membranes requires a thorough understanding of cellular ...
Frida Bällgren, Nana Svane, Aghavni Ginosyan, Alberte Bay Villekjaer Pedersen, Shannuo Li, Jessica Mahajan, Morten Schallburg Nielsen, Birger Brodin, Irena Loryan   +8 more
doaj   +2 more sources

The Active Glucuronide Metabolite of the Brain Protectant IMM-H004 with Poor Blood–Brain Barrier Permeability Demonstrates a High Partition in the Rat Brain via Multiple Mechanisms [PDF]

Pharmaceutics
Background: Glucuronidation is an essential metabolic pathway for a variety of drugs. IMM-H004 is a novel neuroprotective agent against ischemic stroke, and its glucuronide metabolite IMM-H004G exhibits similar pharmacological activity.
Jianwei Jiang, Lijun Luo, Ziqian Zhang, Xiao Liu, Naihong Chen, Yan Li, Li Sheng   +6 more
doaj   +2 more sources

Efeito analgésico de antagonistas do receptor da histamina H1 em modelo de dor provocada por formalina em ratos Efecto analgésico de antagonistas del receptor de la histamina H1 en un modelo de dolor provocado por formalina en ratones Analgesic effects of H1 receptor antagonists in the rat model of formalin-induced pain

Revista Brasileira de Anestesiologia, 2009
JUSTIFICATIVA E OBJETIVOS: Os receptores de histamina mediam vias nociceptivas principalmente no sistema nervoso central. Alguns estudos mostraram efeito analgésico de antagonistas de receptor de histamina no sistema nervoso periférico. Não está claro se
Hazem Adel Ashmawi, Leandro Mamede Braun, Angela Maria Sousa, Irimar de Paula Posso   +3 more
doaj   +1 more source