Results 41 to 50 of about 1,774 (189)

Inonotus obliquus attenuates histamine-induced microvascular inflammation.

PLoS ONE, 2019
Cell-to-cell communication is a key element of microvascular blood flow control, including rapidly carrying signals through the vascular endothelium in response to local stimuli.
Sumreen Javed, Kevin Mitchell, Danielle Sidsworth, Stephanie L Sellers, Jennifer Reutens-Hernandez, Hugues B Massicotte, Keith N Egger, Chow H Lee, Geoffrey W Payne   +8 more
doaj   +1 more source

Mechanisms Underlying the Vasorelaxant Effect Induced by Proanthocyanidin-Rich Fraction From Croton celtidifolius in Rat Small Resistance Arteries

Journal of Pharmacological Sciences, 2008
Proanthocyanidins are condensed tannins present in fruits, vegetables, and flowers, consumed in the human diet. These compounds are believed to decrease coronary heart disease.
Silvia DalBó, Eduardo Gasnhar Moreira, Fernanda Costa Brandão, Heros Horst, Moacir Geraldo Pizzolatti, Gustavo Amadeu Micke, Rosa Maria Ribeiro-do-Valle   +6 more
doaj   +1 more source

Cyanide Beyond Toxicity: A Systematic Review of Its Effects on Vascular Function

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 5, November 2025.
ABSTRACT Cyanide is widely recognized for its potent toxicity, yet evidence shows that concentrations below 1 μM may enhance cytochrome c oxidase activity and have a regulatory function. Recent findings also demonstrate that mammalian cells, including endothelial cells, produce cyanide endogenously, where it can modulate mitochondrial bioenergetics ...
Elif Alan‐Albayrak, Ulf Simonsen
wiley   +1 more source

Species-specific pharmacology of maximakinin, an amphibian homologue of bradykinin: putative prodrug activity at the human B2 receptor and peptidase resistance in rats [PDF]

PeerJ, 2017
Maximakinin (MK), an amphibian peptide possessing the C-terminal sequence of bradykinin (BK), is a BK B2 receptor (B2R) agonist eliciting prolonged signaling.
Xavier Charest-Morin, Hélène Bachelard, Melissa Jean, Francois Marceau   +3 more
doaj   +2 more sources

Association of Inpatient Prescribing of First‐Generation Antihistamines With Delirium in Older Adults: A Cross‐Sectional Study

Journal of the American Geriatrics Society, Volume 73, Issue 11, Page 3475-3483, November 2025.
ABSTRACT Background Small studies have reported associations between first‐generation antihistamines and delirium. It is unclear whether first‐generation antihistamines cause clinically important delirium among older adult inpatients. Objective To estimate the association between inpatient physician prescribing of first‐generation antihistamines and ...
Alanna C. Bridgman, Mohammad Arshad Imrit, Surain B. Roberts, Mina Tadrous, Nathan M. Stall, Michael Fralick, Jennifer Watt, Amol A. Verma, Fahad Razak, Aaron M. Drucker   +9 more
wiley   +1 more source

Decoding Pain: Next‐Generation In Vitro Systems for Mechanistic Insights and Drug Discovery

The FASEB Journal, Volume 39, Issue 16, 31 August 2025.
Developing an in vitro pain model that mimics essential features of the in vivo pain circuit requires careful consideration of multiple components and choices. These include selecting the cellular population for the model, choosing from the origin of nociceptors and other cells that are cultured, deciding between 3D or 2D dimensions, designing the ...
Dara Khosrowshahi, Liesbet Lagae, Johanna Bolander   +2 more
wiley   +1 more source

Combination Therapies of the Neurotransmitter-Targeting Drugs Dextromethorphan, Pyrilamine and Lorcaserin in a Rat Model of Nicotine Addiction [PDF]

, 2014
Honors Thesis in Biology: Basis for study to be published in "Neuroscience"Given the current epidemic of nicotine dependence, the study of interactions between neurotransmitter receptor-targeting molecules to discover possible new forms of smoking ...
Briggs, Scott
core   +1 more source

Marjoram Relaxes Rat Thoracic Aorta Via a PI3-K/eNOS/cGMP Pathway

Biomolecules, 2019
Despite pharmacotherapeutic advances, cardiovascular disease (CVD) remains the primary cause of global mortality. Alternative approaches, such as herbal medicine, continue to be sought to reduce this burden.
Adnan Badran, Elias Baydoun, Ali Samaha, Gianfranco Pintus, Joelle Mesmar, Rabah Iratni, Khodr Issa, Ali H. Eid   +7 more
doaj   +1 more source

MRGPRX2 Mediates Mast Cell‐Induced Endometriosis Pain Through the Sensitization of Sensory Neurons via Histamine/HRH1/TRPV1 Signaling Pathway

The FASEB Journal, Volume 39, Issue 13, 15 July 2025.
Endometriotic cell‐derived HBD‐2 mediated the secretion of histamine from mast cells by binding to MRGPRX2. Histamine sensitized TRPV1 via the activation of HRH1 in pain sensory neurons, thus aggravating hyperalgesia in an endometriosis model. ABSTRACT The studies on how mast cells mediate endometriosis pain are still limited.
Xinqi Mao, Jianzhang Wang, Shaojie Ding, Xinyue Guo, Xinxin Xu, Ping Xu, Xinmei Zhang   +6 more
wiley   +1 more source

Involvement of the pyrilamine transporter, a putative organic cation transporter, in blood-brain barrier transport of oxycodone

, 2008
The purpose of this study was to characterize blood-brain barrier (BBB) transport of oxycodone, a cationic opioid agonist, via the pyrilamine transporter, a putative organic cation transporter, using conditionally immortalized rat brain capillary ...
Sato, Takenori, Hammarlund-Udenaes, Margareta,, Yoshiharu Deguchi, Hattori, Asami, Okura, Takashi, Asami Hattori, Deguchi, Yoshiharu, Yusuke Takano, Takenori Sato, Margareta Hammarlund-udenaes, Takashi Okura, Terasaki, Tetsuya, Tetsuya Terasaki, Takano, Yusuke   +13 more
core   +1 more source