Results 41 to 50 of about 1,692 (191)
Species-specific pharmacology of maximakinin, an amphibian homologue of bradykinin: putative prodrug activity at the human B2 receptor and peptidase resistance in rats [PDF]
PeerJ, 2017 Maximakinin (MK), an amphibian peptide possessing the C-terminal sequence of bradykinin (BK), is a BK B2 receptor (B2R) agonist eliciting prolonged signaling.
Xavier Charest-Morin +3 more
doaj +2 more sources
Cyanide Beyond Toxicity: A Systematic Review of Its Effects on Vascular Function
Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 5, November 2025.ABSTRACT Cyanide is widely recognized for its potent toxicity, yet evidence shows that concentrations below 1 μM may enhance cytochrome c oxidase activity and have a regulatory function. Recent findings also demonstrate that mammalian cells, including endothelial cells, produce cyanide endogenously, where it can modulate mitochondrial bioenergetics ...
Elif Alan‐Albayrak, Ulf Simonsen
wiley +1 more source
, 2016 Experiments using non-steroidal anti-inflammatory drugs (NSAIDs) alone have produced limited antinociceptive effects in animal models. For this reason, the number of studies involving the administration of NSAIDs along with an adjuvant drug harboring ...
Ortiz, Mario I.
core +1 more source
Journal of the American Geriatrics Society, Volume 73, Issue 11, Page 3475-3483, November 2025.ABSTRACT Background Small studies have reported associations between first‐generation antihistamines and delirium. It is unclear whether first‐generation antihistamines cause clinically important delirium among older adult inpatients. Objective To estimate the association between inpatient physician prescribing of first‐generation antihistamines and ...
Alanna C. Bridgman +9 more
wiley +1 more source
Analysis of histamine as a hair-cell transmitter in the lateral line of Xenopus laevis [PDF]
, 1989 The actions of histamine and histamine antagonists on afferent nerve activity were investigated in the lateral line of Xenopus laevis. Histamine (0.002-2.0 mM) had no effect on spontaneous activity or excitatory responses to water motion.
Allen, Susan J. +2 more
core +1 more source
Decoding Pain: Next‐Generation In Vitro Systems for Mechanistic Insights and Drug Discovery
The FASEB Journal, Volume 39, Issue 16, 31 August 2025.Developing an in vitro pain model that mimics essential features of the in vivo pain circuit requires careful consideration of multiple components and choices. These include selecting the cellular population for the model, choosing from the origin of nociceptors and other cells that are cultured, deciding between 3D or 2D dimensions, designing the ...
Dara Khosrowshahi +2 more
wiley +1 more source
, 2008 The purpose of this study was to characterize blood-brain barrier (BBB) transport of oxycodone, a cationic opioid agonist, via the pyrilamine transporter, a putative organic cation transporter, using conditionally immortalized rat brain capillary ...
Sato, Takenori +13 more
core +1 more source
Iranian Journal of Psychiatry, 2010 Objective: The nucleus accumbens (NAc) receive histaminergic neurons from tuberomammillary nuclei. There are reports indicating that central histamine systems are involved in many physiological behavioral processes, including anxiety.
Mohammad-Reza Zarrindast +2 more
doaj +2 more sources
Marjoram Relaxes Rat Thoracic Aorta Via a PI3-K/eNOS/cGMP Pathway
Biomolecules, 2019 Despite pharmacotherapeutic advances, cardiovascular disease (CVD) remains the primary cause of global mortality. Alternative approaches, such as herbal medicine, continue to be sought to reduce this burden.
Adnan Badran +7 more
doaj +1 more source
Stem Cell Research & Therapy, 2020 Background The efficiency and quality of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are crucial for regenerative medicine, disease modeling, drug screening, and the study of the development events during cardiac specification.
Xiaowei Zhu +9 more
doaj +1 more source