Results 21 to 30 of about 1,693 (192)

Critical role of mitogen‐inducible gene 6 in restraining endothelial cell permeability to maintain vascular homeostasis

Journal of Cell Communication and Signaling, Volume 17, Issue 1, Page 151-165, March 2023., 2023
Graphical abstract Xing et al. (2022) investigated the critical role of MIG6 in vascular permeability. MIG6 deficiency promotes VEGFA‐induced vascular permeability via activation of PLCγ1‐Ca2+‐eNOS signaling and perturbation of the balance in RAC1/RHOA activation, resulting in endothelial barrier disruption.
Liying Xing, Guanqun Huang, Rongyuan Chen, Lijuan Huang, Juanxi Liu, Xiangrong Ren, Shasha Wang, Haiqing Kuang, Anil Kumar, Jong Kyong Kim, Qin Jiang, Xuri Li, Chunsik Lee   +12 more
wiley   +1 more source

Bioactive Compounds in Ficus Fruits, Their Bioactivities, and Associated Health Benefits: A Review

Journal of Food Quality, Volume 2022, Issue 1, 2022., 2022
Bioactive compounds are secondary metabolites synthesized by plants for maintaining homeostasis; however, they also modulate metabolic processes and demonstrate valuable effects in the human body. The fig was cherished as food and for its pharmaceutical properties.
Ankita Walia, Naveen Kumar, Rajat Singh, Harish Kumar, Vikas Kumar, Ravinder Kaushik, Avvaru Praveen Kumar, Milan Stankovic   +7 more
wiley   +1 more source

The widely used antihistamine mepyramine causes topical pain relief through direct blockade of nociceptor sodium channels

The FASEB Journal, Volume 35, Issue 12, December 2021., 2021
Abstract Mepyramine, a first‐generation antihistamine targeting the histamine H(1) receptor, was extensively prescribed to patients suffering from allergic reactions and urticaria. Serious adverse effects, especially in case of overdose, were frequently reported, including drowsiness, impaired thinking, convulsion, and coma.
Jizhe Hao, Lucie Brosse, Caroline Bonnet, Myriam Ducrocq, Françoise Padilla, Virginie Penalba, Angélique Desplat, Jérôme Ruel, Patrick Delmas   +8 more
wiley   +1 more source

Subchronic Studies of Pyrilamine in B6C3F₁ Mice [PDF]

, 1993
The purpose of this study was to determine the effects of subchronic exposure to the antihistamine pyrilamine maleate and to establish dosage levels to use in a 2-year chronic study. A 14-day repeated-dose study in male and female B6C3F1 mice at dietary
David W. Gaylor, David L. Greenman, Robert Morrissey, William T. Allaben   +3 more
core   +1 more source

Analytical and Pharmacological Characterization of 1-(Furan-2-Carbonyl)-LSD (1F-LSD) and Comparison With 1-(Thiophene-2-Carbonyl)-LSD (1T-LSD). [PDF]

Drug Test Anal
The novel lysergamide 1‐(furan‐2‐carbonyl)‐LSD (1F‐LSD) was analytically characterized. 1F‐LSD showed LSD‐like activity in vivo similar to 1‐(thiophene‐2‐carbonyl)‐LSD (1T‐LSD) used for comparison. Administration studies in mice and LC–MS analysis revealed that 1F‐LSD served as a prodrug.
Brandt SD, Kavanagh PV, Gare S, Elliott SP, Stratford A, Halberstadt AL.   +5 more
europepmc   +2 more sources

Effect of histamine and compound 48/80 on the conduction of vasodilation in the presence of pyrilamine. [PDF]

, 2019
Pyrilamine abolished the effect of histamine on reducing conducted vasodilation but combination of C48/80 and pyrilamine, a significant reduction in conducted vasodilation was still observed.
Keith N. Egger (7300358), Sumreen Javed (7300346), Kevin Mitchell (3948488), Geoffrey W. Payne (7300364), Hugues B. Massicotte (7300355), Stephanie L. Sellers (7208339), Chow H. Lee (7300361), Danielle Sidsworth (7300349), Jennifer Reutens-Hernandez (7300352)   +8 more
core   +1 more source

Synergistic interaction between Diclofenac and Pyrilamine on nociception, inflammation and gastric damage in rats [PDF]

, 2016
Experiments using non-steroidal anti-inflammatory drugs (NSAIDs) alone have produced limited antinociceptive effects in animal models. For this reason, the number of studies involving the administration of NSAIDs along with an adjuvant drug harboring ...
Ortiz, Mario I.
core   +2 more sources

Typical and Atypical Antipsychotic Drugs Increase Extracellular Histamine Levels in the Rat Medial Prefrontal Cortex: Contribution of Histamine H1 Receptor Blockade

Frontiers in Psychiatry, 2012
Atypical antipsychotics such as clozapine and olanzapine have been shown to enhance histamine turnover and this effect has been hypothesized to contribute to their improved therapeutic profile compared to typical antipsychotics.
Kjell A Svensson
doaj   +1 more source

Uptake Study in Lysosome-Enriched Fraction: Critical Involvement of Lysosomal Trapping in Quinacrine Uptake but Not Fluorescence-Labeled Verapamil Transport at Blood-Retinal Barrier

Pharmaceutics, 2020
Lysosomal trapping at the blood–retinal barrier (BRB) was investigated through quinacrine and fluorescence-labeled verapamil (EFV) uptake. Quinacrine uptake by conditionally immortalized rat retinal capillary endothelial (TR-iBRB2) cells suggested ...
Yoshiyuki Kubo, Miki Yamada, Saki Konakawa, Shin-ichi Akanuma, Ken-ichi Hosoya   +4 more
doaj   +1 more source

Carrier-Mediated Delivery of Low-Molecular-Weight N-Containing Drugs across the Blood–Brain Barrier or the Blood–Retinal Barrier Using the Proton-Coupled Organic Cation Antiporter

Future Pharmacology, 2023
While it is true that pharmacotherapy has achieved desired health outcomes, significant unmet medical needs persist in the field of central nervous system (CNS) drugs, particularly for neurodegenerative diseases such as Alzheimer’s disease, as well as ...
Toshihiko Tashima
doaj   +1 more source