Results 11 to 20 of about 1,693 (192)
Pyrilamine and O-Desmethylpyrilamine Detection in Equine Serum and Urine [PDF]
Journal of Analytical Toxicology, 2008 Pyrilamine (mepyramine) is an H1-receptor antagonist used in human and veterinary medicine. It has the potential to produce central nervous system effects in horses and therefore may have some impact on an outcome of a horse race. A single oral dose of pyrilamine (300 mg/horse) was given to three animals.
Marc, Benoit +12 more
openaire +4 more sources
The evidence for histamine H3 receptor-mediated endothelium-dependent relaxation in isolated rat aorta [PDF]
Mediators of Inflammation, 1995 The presence of histamine H3 receptors was evaluated on the rat aorta endothelium. In the presence of pyrilamine (1 nM, 7 nM, 10 nM) or thioperamide (1 nM, 10 nM, 30 nM) the concentration–response curve for histamine-induced (0.1 nM − 0.01 mM ...
D. M. Djuric, I. Z. Andjelkovic
doaj +2 more sources
Blocking Histamine H1 Improves Learning and Mnemonic Dysfunction in Mice With Social Isolation Plus Repeated Methamphetamine Injection [PDF]
Journal of Pharmacological Sciences, 2008 The aim of this study was to investigate the effects of histamine H1 and H3 antagonists on learning and mnemonic dysfunction in mice. Two H1 antagonists, pyrilamine and clozapine, and the prototypic H3 antagonist thioperamide were used to study the role ...
Feiyong Jia +9 more
doaj +2 more sources
Effects of membrane transport activity and cell metabolism on the unbound drug concentrations in the skeletal muscle and liver of drugs: A microdialysis study in rats. [PDF]
Pharmacol Res Perspect, 2021 Unbound concentrations of of 14 commercial drugs in rat liver, muscle, and blood Abstract The unbound concentrations of 14 commercial drugs, including five non‐efflux/uptake transporter substrates—Class I, five efflux transporter substrates—class II and four influx transporter substrates—Class III, were simultaneously measured in rat liver, muscle, and
Wang S +11 more
europepmc +2 more sources
Positive chronotropic action of HCN channel antagonism in human collecting lymphatic vessels. [PDF]
Physiol Rep, 2022 Hyperpolarisation‐activated cyclic‐nucleotide gated (HCN) channels primarily determine sinoatrial pacemaking. In human lymphatic vessels HCN channel proteins are also expressed but have a negligible functional role in ex vivo phasic activity when investigated using the HCN inhibitors ivabradine, ZD7288 and caesium.
Majgaard J +4 more
europepmc +2 more sources
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
British Journal of Pharmacology, Volume 180, Issue S2, Page S23-S144, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander +165 more
wiley +1 more source
Improved PIEZO1 agonism through 4‐benzoic acid modification of Yoda1
British Journal of Pharmacology, Volume 180, Issue 16, Page 2039-2063, August 2023., 2023 Background and Purpose The protein PIEZO1 forms mechanically activated, calcium‐permeable, non‐selective cation channels in numerous cell types from several species. Options for pharmacological modulation are limited and so we modified a small‐molecule agonist at PIEZO1 channels (Yoda1) to increase the ability to modulate these channels.
Gregory Parsonage +18 more
wiley +1 more source
Neurogastroenterology &Motility, Volume 35, Issue 7, July 2023., 2023 Low molecular extracts from birch, ragweed, and hazel pollen strongly excite enteric and DRG neurons. Nerve activation was mediated by histamine in birch and ragweed, but not in hazel pollen extracts. Abstract Background Non‐allergenic, low molecular weight components of pollen grains are suspected to trigger changes in gut functions, sometimes leading
Sabine Buhner +7 more
wiley +1 more source
The transport function of the human lymphatic system—A systematic review
Physiological Reports, Volume 11, Issue 11, June 2023., 2023 Abstract Physiological properties and function of the lymphatic system is still somewhat of a mystery. We report the current knowledge about human lymphatic vessel contractility and capability of adaptation. A literature search in PubMed identified studies published January 2000–September 2022.
Lene Thorup +4 more
wiley +1 more source