Results 11 to 20 of about 1,692 (191)

Pyrilamine in the horse: detection and pharmacokinetics of pyrilamine and its major urinary metaboliteO‐desmethylpyrilamine [PDF]

Journal of Veterinary Pharmacology and Therapeutics, 2009
Pyrilamine is an antihistamine used in human and veterinary medicine. As antihistamines produce central nervous system effects in horses, pyrilamine has the potential to affect the performance of racehorses. In the present study,O‐desmethylpyrilamine (O‐DMP) was observed to be the predominant equine urinary metabolite of pyrilamine.
L, Dirikolu, A F, Lehner, J D, Harkins, W E, Woods, W, Karpiesiuk, R S, Gates, M, Fisher, T, Tobin   +7 more
openaire   +4 more sources

Comparison of Pulmonary Accumulation of Pyrilamine and Pyrilamine N-oxide

Japanese Journal of Pharmacology, 1985
Our previous studies have indicated that a phenothiazine drug, chlorpromazine, and a tricyclic antidepressant, imipramine, are metabolized by the isolated perfused rat lungs via N-oxidation from whence their N-oxides are released into the circulation. This work was undertaken to compare the pulmonary accumulation of another pneumophilic tertiary amine ...
OHMIYA, Yoshio, FUJISAWA, Susumu, NAKAI, Kengo   +2 more
openaire   +4 more sources

Pyrilamine and O-Desmethylpyrilamine Detection in Equine Serum and Urine [PDF]

Journal of Analytical Toxicology, 2008
Pyrilamine (mepyramine) is an H1-receptor antagonist used in human and veterinary medicine. It has the potential to produce central nervous system effects in horses and therefore may have some impact on an outcome of a horse race. A single oral dose of pyrilamine (300 mg/horse) was given to three animals.
Marc, Benoit, Kelly, Lingen, Lisa M, Taddei, Brendan T, Heffron, Laura, Hurt, Joseph A, Lokanc, Katherine, Lingner, Esau, Cardenas, Salvador, Flores, David, Mayer, Donna, Pilipiak, Dawn, Folker-Calderon, Adam, Negrusz   +12 more
openaire   +3 more sources

Ameliorative Effect of a Hippocampal Metabotropic Glutamate– Receptor Agonist on Histamine H1 Receptor Antagonist–Induced Memory Deficit in Rats

Journal of Pharmacological Sciences, 2010
This study was performed to investigate the ameliorative effects of metabotropic glutamate (mGlu)-receptor agonists on histamine H1 receptor antagonist–induced spatial memory deficit and the decrease in hippocampal theta activity in rats. Intraperitoneal
Takayoshi Masuoka, Azusa Mikami, Chiaki Kamei   +2 more
doaj   +2 more sources

The evidence for histamine H3 receptor-mediated endothelium-dependent relaxation in isolated rat aorta [PDF]

Mediators of Inflammation, 1995
The presence of histamine H3 receptors was evaluated on the rat aorta endothelium. In the presence of pyrilamine (1 nM, 7 nM, 10 nM) or thioperamide (1 nM, 10 nM, 30 nM) the concentration–response curve for histamine-induced (0.1 nM − 0.01 mM ...
D. M. Djuric, I. Z. Andjelkovic
doaj   +2 more sources

Blocking Histamine H1 Improves Learning and Mnemonic Dysfunction in Mice With Social Isolation Plus Repeated Methamphetamine Injection

Journal of Pharmacological Sciences, 2008
The aim of this study was to investigate the effects of histamine H1 and H3 antagonists on learning and mnemonic dysfunction in mice. Two H1 antagonists, pyrilamine and clozapine, and the prototypic H3 antagonist thioperamide were used to study the role ...
Feiyong Jia, Jalal Izadi Mobarakeh, Hongmei Dai, Motohisa Kato, Ajing Xu, Tomohiro Okuda, Eiko Sakurai, Nobuyuki Okamura, Kazuhiro Takahashi, Kazuhiko Yanai   +9 more
doaj   +2 more sources

Pyrilamine/Pamabrom/Acetaminophen [PDF]

, 2020
openaire   +2 more sources

Improved PIEZO1 agonism through 4‐benzoic acid modification of Yoda1

British Journal of Pharmacology, Volume 180, Issue 16, Page 2039-2063, August 2023., 2023
Background and Purpose The protein PIEZO1 forms mechanically activated, calcium‐permeable, non‐selective cation channels in numerous cell types from several species. Options for pharmacological modulation are limited and so we modified a small‐molecule agonist at PIEZO1 channels (Yoda1) to increase the ability to modulate these channels.
Gregory Parsonage, Kevin Cuthbertson, Naima Endesh, Nicoletta Murciano, Adam J. Hyman, Charlotte H. Revill, Oleksandr V. Povstyan, Eulashini Chuntharpursat‐Bon, Marjolaine Debant, Melanie J. Ludlow, Timothy Simon Futers, Laeticia Lichtenstein, Jacob A. Kinsella, Fiona Bartoli, Maria Giustina Rotordam, Nadine Becker, Andrea Brüggemann, Richard Foster, David J. Beech   +18 more
wiley   +1 more source

Allergen‐free extracts from birch, ragweed, and hazel pollen activate human and guinea‐pig submucous and spinal sensory neurons

Neurogastroenterology &Motility, Volume 35, Issue 7, July 2023., 2023
Low molecular extracts from birch, ragweed, and hazel pollen strongly excite enteric and DRG neurons. Nerve activation was mediated by histamine in birch and ragweed, but not in hazel pollen extracts. Abstract Background Non‐allergenic, low molecular weight components of pollen grains are suspected to trigger changes in gut functions, sometimes leading
Sabine Buhner, Stefanie Schäuffele, Pieter Giesbertz, Ihsan Ekin Demir, Florian Zeller, Claudia Traidl‐Hoffmann, Michael Schemann, Stefanie Gilles   +7 more
wiley   +1 more source

The transport function of the human lymphatic system—A systematic review

Physiological Reports, Volume 11, Issue 11, June 2023., 2023
Abstract Physiological properties and function of the lymphatic system is still somewhat of a mystery. We report the current knowledge about human lymphatic vessel contractility and capability of adaptation. A literature search in PubMed identified studies published January 2000–September 2022.
Lene Thorup, Anders Hjortdal, Donna B. Boedtkjer, Morten B. Thomsen, Vibeke Hjortdal   +4 more
wiley   +1 more source