Results 51 to 60 of about 1,692 (191)

MRGPRX2 Mediates Mast Cell‐Induced Endometriosis Pain Through the Sensitization of Sensory Neurons via Histamine/HRH1/TRPV1 Signaling Pathway

The FASEB Journal, Volume 39, Issue 13, 15 July 2025.
Endometriotic cell‐derived HBD‐2 mediated the secretion of histamine from mast cells by binding to MRGPRX2. Histamine sensitized TRPV1 via the activation of HRH1 in pain sensory neurons, thus aggravating hyperalgesia in an endometriosis model. ABSTRACT The studies on how mast cells mediate endometriosis pain are still limited.
Xinqi Mao, Jianzhang Wang, Shaojie Ding, Xinyue Guo, Xinxin Xu, Ping Xu, Xinmei Zhang   +6 more
wiley   +1 more source

Tools for clinical pharmacists to identify medications that can cause drug‐induced cognitive impairment: A systematic review

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 7, Issue 12, Page 1207-1227, December 2024.
Abstract Cognitive impairment affects around 19% of community‐dwelling older adults in the United States. Pharmacists can play a significant role in identifying and deprescribing cognitive‐impairing medications through cognitive‐focused medication reviews or as part of comprehensive medication management.
Jacob Stanton, Michael R. Gionfriddo, Gail B. Rattinger, Yuan Fang, Mia E. Lussier   +4 more
wiley   +1 more source

Simultaneous Determination of Acetaminophen, Pamabrom and Pyrilamine Maleate in Pharmaceutical Formulations Using Stability Indicating HPLC Assay Method

, 2017
A simple, specific and accurate stability indicating RPHPLC method was developed for the determination of acetaminophen, pamabrom and pyrilamine maleate simultaneously in pharmaceutical dosage forms.
Muhammad Ashfaq
core   +1 more source

Functional G-Protein-Coupled Receptor (GPCR) Synthesis: The Pharmacological Analysis of Human Histamine H1 Receptor (HRH1) Synthesized by a Wheat Germ Cell-Free Protein Synthesis System Combined with Asolectin Glycerosomes

Frontiers in Pharmacology, 2018
G-protein-coupled receptors (GPCRs) are membrane proteins distributed on the cell surface, and they may be potential drug targets. However, synthesizing GPCRs in vitro can be challenging. Recently, some cell-free protein synthesis systems have been shown
Yasuyuki Suzuki, Tomio Ogasawara, Yuki Tanaka, Hiroyuki Takeda, Tatsuya Sawasaki, Masaki Mogi, Shuang Liu, Kazutaka Maeyama   +7 more
doaj   +1 more source

Binding characteristics of the doxepin E/Z‐isomers to the histamine H1 receptor revealed by receptor‐bound ligand analysis and molecular dynamics study

Journal of Molecular Recognition, Volume 37, Issue 5, September 2024.
Abstract Doxepin is an antihistamine and tricyclic antidepressant that binds to the histamine H1 receptor (H1R) with high affinity. Doxepin is an 85:15 mixture of the E‐ and Z‐isomers. The Z‐isomer is well known to be more effective than the E‐isomer, whereas based on the crystal structure of the H1R/doxepin complex, the hydroxyl group of Thr1123.37 is
Hiroto Kaneko, Ryunosuke Korenaga, Ryota Nakamura, Shinnosuke Kawai, Tadashi Ando, Mitsunori Shiroishi   +5 more
wiley   +1 more source

Salvia fruticosa Induces Vasorelaxation In Rat Isolated Thoracic Aorta: Role of the PI3K/Akt/eNOS/NO/cGMP Signaling Pathway

Scientific Reports, 2017
Salvia fruticosa (SF) Mill. is traditionally used for its antihypertensive actions. However, little is known about its pharmacologic and molecular mechanisms of action.
M. Akhtar Anwar, Ali A. Samaha, Samar Ballan, Alaaeldin I. Saleh, Rabah Iratni, Ali H. Eid   +5 more
doaj   +1 more source

Assessing the anticholinergic cognitive burden classification of putative anticholinergic drugs using drug properties

British Journal of Clinical Pharmacology, Volume 90, Issue 9, Page 2236-2255, September 2024.
Aims This study evaluated the use of machine learning to leverage drug absorption, distribution, metabolism and excretion (ADME) data together with physicochemical and pharmacological data to develop a novel anticholinergic burden scale and compare its performance to previously published scales.
Geofrey Oteng Phutietsile, Nikoletta Fotaki, Prasad S. Nishtala   +2 more
wiley   +1 more source

Additional file 3 of Disruption of histamine/H1R signaling pathway represses cardiac differentiation and maturation of human induced pluripotent stem cells

, 2020
Additional file 3: : Video 1 The morphology and beating behavior of zebrafish after pyrilamine treatment at 96 hours post ...
Zhiwei Zhang (12077), Junbo Ge (385426), Xiaowei Zhu (24440), Suling Ding (7858091), Jian Wu (41301), Hui Li (32376), Xiangfei Wang (8528514), Yunzeng Zou (188550), Lili Xu (257856), Xiangdong Yang (287443)   +9 more
core   +1 more source

Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine‐Independent and Chronic Itch

Advanced Science, Volume 11, Issue 15, April 17, 2024.
The potassium channel Slack is highly expressed in sensory neurons that sense itch. In this study, several new compounds that activate Slack are developed. It is found that the lead molecule, compound 6, effectively inhibits scratching elicited by multiple pruritogens in mice establishing Slack activation as a novel pharmacological strategy for the ...
Annika Balzulat, W. Felix Zhu, Cathrin Flauaus, Victor Hernandez‐Olmos, Jan Heering, Sunesh Sethumadhavan, Mariam Dubiel, Annika Frank, Amelie Menge, Maureen Hebchen, Katharina Metzner, Ruirui Lu, Robert Lukowski, Peter Ruth, Stefan Knapp, Susanne Müller, Dieter Steinhilber, Inga Hänelt, Holger Stark, Ewgenij Proschak, Achim Schmidtko   +20 more
wiley   +1 more source

The Histamine H3 Receptor Antagonist E159 Reverses Memory Deficits Induced by Dizocilpine in Passive Avoidance and Novel Object Recognition Paradigm in Rats

Frontiers in Pharmacology, 2017
The involvement of histamine H3 receptors (H3Rs) in memory is well known, and the potential of H3R antagonists in therapeutic management of neuropsychiatric diseases, e.g., Alzheimer disease (AD) is well established.
Alaa Alachkar, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sadek   +3 more
doaj   +1 more source