Results 51 to 60 of about 1,693 (192)
Decoding Pain: Next‐Generation In Vitro Systems for Mechanistic Insights and Drug Discovery
The FASEB Journal, Volume 39, Issue 16, 31 August 2025.Developing an in vitro pain model that mimics essential features of the in vivo pain circuit requires careful consideration of multiple components and choices. These include selecting the cellular population for the model, choosing from the origin of nociceptors and other cells that are cultured, deciding between 3D or 2D dimensions, designing the ...
Dara Khosrowshahi +2 more
wiley +1 more source
Protective effects of histamine on Gq-mediated relaxation in regenerated endothelium [PDF]
, 2014 In the porcine coronary artery, regenerated endothelium is dysfunctional as regards the responses to endothelium-dependent agonists. The current study aimed to determine the possible involvement of histamine in such dysfunction.
Chan, Calvin K. +5 more
core +1 more source
Marjoram Relaxes Rat Thoracic Aorta Via a PI3-K/eNOS/cGMP Pathway
Biomolecules, 2019 Despite pharmacotherapeutic advances, cardiovascular disease (CVD) remains the primary cause of global mortality. Alternative approaches, such as herbal medicine, continue to be sought to reduce this burden.
Adnan Badran +7 more
doaj +1 more source
The FASEB Journal, Volume 39, Issue 13, 15 July 2025.Endometriotic cell‐derived HBD‐2 mediated the secretion of histamine from mast cells by binding to MRGPRX2. Histamine sensitized TRPV1 via the activation of HRH1 in pain sensory neurons, thus aggravating hyperalgesia in an endometriosis model. ABSTRACT The studies on how mast cells mediate endometriosis pain are still limited.
Xinqi Mao +6 more
wiley +1 more source
A Novel RP-HPLC Method for the Simultaneous Analysis of Some Active Ingredients in Cough-Cold Syrup Formulation [PDF]
, 2017 Background: This study deals with the development of an RP-HPLC method for paracetamol (PAR), guaifenesin (GUA), phenylephrine hydrochloride (PEH), and pyrilamine maleate (PAM) in a commercial syrup formulation using experimental ...
Gizem Yarkadas +7 more
core +1 more source
Iranian Journal of Psychiatry, 2010 Objective: The nucleus accumbens (NAc) receive histaminergic neurons from tuberomammillary nuclei. There are reports indicating that central histamine systems are involved in many physiological behavioral processes, including anxiety.
Mohammad-Reza Zarrindast +2 more
doaj +2 more sources
Stem Cell Research & Therapy, 2020 Background The efficiency and quality of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are crucial for regenerative medicine, disease modeling, drug screening, and the study of the development events during cardiac specification.
Xiaowei Zhu +9 more
doaj +1 more source
JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 7, Issue 12, Page 1207-1227, December 2024.Abstract Cognitive impairment affects around 19% of community‐dwelling older adults in the United States. Pharmacists can play a significant role in identifying and deprescribing cognitive‐impairing medications through cognitive‐focused medication reviews or as part of comprehensive medication management.
Jacob Stanton +4 more
wiley +1 more source
Regionally variable pulmonary artery responses to C3a [PDF]
, 1988 Products of the complement (C) cascade may have direct effects on pulmonary vascular tissue and contribute to pulmonary vasoconstriction in states of C activation.
T. W. Chick +6 more
core +1 more source
Additional file 5 of Disruption of histamine/H1R signaling pathway represses cardiac differentiation and maturation of human induced pluripotent stem cells [PDF]
, 2020 Additional file 5 : Figure S3. (related to Fig. 5). The function of histamine in cardiac differentiation may be mediated by histamine 1 receptor. (A) The mRNA levels of H1R, and H2R during cardiac differentiation.
Zhiwei Zhang (12077) +9 more
core +1 more source