A Robust and Universal LC-MS/MS Method for Determination of N-Nitrosodimethylamine in Pharmaceuticals Using a C30 Column. [PDF]
J Sep SciABSTRACT Since the 2018 valsartan recall, the genotoxic impurity N‐nitrosodimethylamine (NDMA) has been frequently detected in various pharmaceuticals. Matrix variability often complicates routine testing, requiring customized analyses. We developed a universal LC–MS/MS method enabling consistent NDMA detection across diverse pharmaceuticals ...
An B +9 more
europepmc +2 more sources
Developing a Chitosan/polyvinyl alcohol hydrogel for gastro-retentive release of ranitidine and enhanced anti-ulcerative properties [PDF]
BMC BiotechnologyRanitidine is widely used to treat gastrointestinal conditions, but recent studies have revealed severe potential side effects, including a link to cancer.
Shimaa A. Sadek +13 more
doaj +2 more sources
Ranitidine protects Müller cells against ferroptosis in diabetic retinopathy by regulating the AKT1/GSK3β pathway [PDF]
Indian Journal of OphthalmologyPurpose: This study was designed to investigate the primary targets and possible mechanisms of ranitidine (Ra) against diabetic retinopathy (DR). Methods: Single-cell sequencing technology and the SPIED3 platform were employed to characterize key genes ...
Wei He +3 more
doaj +2 more sources
Pakistan Armed Forces Medical Journal, 2021 Objective: To explore the prokinetic effect of Ranitidine, to compare it with the prokinetic effect of Neostigmine and to observe the potentiating prokinetic effect of Ranitidine and Neostigmine in combination.
Aroosa Ishtiaq Butt +4 more
doaj +1 more source
Effects of genetic polymorphisms on the OCT1 and OCT2-mediated uptake of ranitidine. [PDF]
PLoS ONE, 2017 Ranitidine (Zantac®) is a H2-receptor antagonist commonly used for the treatment of acid-related gastrointestinal diseases. Ranitidine was reported to be a substrate of the organic cation transporters OCT1 and OCT2. The hepatic transporter OCT1 is highly
Marleen Julia Meyer +3 more
doaj +1 more source
The Study of Ranitidine Interference With Morphine Detection Test by Thin-Layer Chromatography [PDF]
Avicenna Journal of Medical Biochemistry, 2018 Background: Drug abuse is a global and critical problem. One of the most frequent practices done in order to detect the drugs of abuse is Urine Drug Screen. However, for changing the drug test results, adulterants and urine substitutes are being designed.
Amir Miri +3 more
doaj +1 more source
Simultaneous interaction, degradation, and kinetic study of sparfloxacin with H2 receptor antagonist
Pakistan Journal of Pharmaceutical Sciences, 2023 Sparfloxacin is a quinolone carboxylic acid derivative that shows activity as an antimicrobial agent, against a wide range of Gram-negative and Gram-positive organisms.
Shereen +9 more
doaj +1 more source
Corrosion Inhibition of α-brass Alloy in Aqueous Solution by Using Expired Ranitidine
International Journal of Electrochemical Science, 2020 Expired Ranitidine was tested as a corrosion hindrance for α-brass. The result is utilized to identify its maximum concentration in order to be used in the protection of corrosion of α-brass in a HCl medium.
A.S. Fouda +3 more
doaj +1 more source
Association between ranitidine use with potential NDMA impurities and risk of cancer in Korea
Scientific Reports, 2022 N-Nitrosodimethylamine (NDMA) detected above the acceptable level in ranitidine products has been a great global concern. To examine the risk of cancer among people treated with ranitidine, we conducted a cohort study using the National Health Insurance ...
Kyung-In Joung +4 more
doaj +1 more source
Pharmaceuticals, 2023 Background: Histamine H2 receptor antagonists are a group of drugs that inhibit gastric juice secretion in gastrointestinal diseases. However, there is evidence to suggest that H2 blockers have a broader spectrum of activity.
Grzegorz Biedrzycki +6 more
doaj +1 more source