Journal of Pharmacological Sciences, 2006 .: G-protein-coupled receptors (GPCR) represent a large and diverse superfamily of integral membrane proteins to which histamine receptors belong. Increasing numbers of proteins have been identified to interact with the C-termini of GPCRs.
Kuramasu Atsuo +3 more
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Influence of mirtazapine on salivary cortisol in depressed patients [PDF]
, 2003 Unlike other antidepressants, mirtazapine does not inhibit the reuptake of norepinephrine or serotonin but acts as an antagonist at presynaptic alpha(2)-receptors, at postsynaptic 5-HT2 and 5-HT3 receptors, and at histaminergic H1 receptors. Furthermore,
Baghai, Thomas C. +3 more
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Journal of Pharmacological Sciences, 2003 Although it is well known that histamine induces gastric mucosal lesions in laboratory animals, the fundamental mechanisms remain unclear. In order to further analyze the vascular mechanisms underlying histamine-induced lesions, a new model was developed
Kikuko Amagase, Susumu Okabe
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Intestinal epithelial responses to Salmonella enterica serovar Enteritidis: Effects on intestinal permeability and ion transport [PDF]
, 2019 Salmonella infection of chickens that leads to potential human foodborne salmonellosis continues to be a major concern. Chickens serve as carriers but, in contrast to humans, rarely show any clinical signs including diarrhea.
Aschenbach, J. R. +4 more
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Histamine and Histamine H4 Receptor Promotes Osteoclastogenesis in Rheumatoid Arthritis. [PDF]
, 2017 Histamine H4 receptor (H4R) has immune-modulatory and chemotaxic effects in various immune cells. This study aimed to determine the osteoclastogenic role of H4R in rheumatoid arthritis (RA).
Firestein, Gary S +5 more
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Antihistaminergics and inverse agonism. Potential therapeutic applications [PDF]
, 2013 The accurate characterization of the molecular mechanisms involved in the action of receptor ligands is important for their appropriate therapeutic use and safety.
Davio, Carlos Alberto +4 more
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The Histamine H4 Receptor: From Orphan to the Clinic
Frontiers in Pharmacology, 2015 The histamine H4 receptor (H4R) was first noted as a sequence in genomic databases that had features of a G-protein coupled receptor. This putative receptor was found to bind histamine consistent with its homology to other histamine receptors and thus ...
Robin L. Thurmond
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Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity [PDF]
, 2015 Correction of human myeloid cell function is crucial for the prevention of inflammatory and allergic reactions as well as leukaemia progression. Caffeine, a naturally occurring food component, is known to display anti-inflammatory effects which have ...
Abooali, Maryam +8 more
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Histamine and migraine revisited: mechanisms and possible drug targets
The Journal of Headache and Pain, 2019 Objective To review the existing literature on histamine and migraine with a focus on the molecule, its receptors, its use in inducing migraine, and antihistamines in the treatment of migraine. Background Histamine has been known to cause a vascular type
Jacob Worm +2 more
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Novel chalcone-based fluorescent human histamine H 3 receptor ligands as pharmacological tools [PDF]
, 2012 Novel fluorescent chalcone-based ligands at human histamine H(3) receptors (hH(3)R) have been designed, synthesized, and characterized. Compounds described are non-imidazole analogs of ciproxifan with a tetralone motif.
Tomasch, Miriam +3 more
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