Results 121 to 130 of about 81,009,517 (308)

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Dithranol upregulates IL-10 receptors on the cultured human keratinocyte cell line HaCaT

, 2001
OBJECTIVE: Dithranol is highly effective in the treatment of psoriasis, however its mode of action is still not well known. Since interleukin-8 and interleukin-10 are involved in the pathogenesis of psoriasis, the aim of our study was to investigate the ...
Széll, M, Kiss, M, Farkas, A, Pivarcsi, A, Koreck, A, Dobozy, A, Kemény, L, Bata-Csörgö, Z, Szöny, B J   +8 more
core   +1 more source

Molecular and Structural Characterization of a Novel Escherichia coli Interleukin Receptor Mimic Protein

mBio, 2016
Urinary tract infection (UTI) is a disease of extremely high incidence in both community and nosocomial settings. UTIs cause significant morbidity and mortality, with approximately 150 million cases globally per year. Uropathogenic Escherichia coli (UPEC)
Danilo G. Moriel, Begoña Heras, Jason J. Paxman, Alvin W. Lo, Lendl Tan, Matthew J. Sullivan, Samantha J. Dando, Scott A. Beatson, Glen C. Ulett, Mark A. Schembri   +9 more
doaj   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Interleukin-10/Interleukin-5 responses at birth predict risk for respiratory infections in children with atopic family history

, 2009
Interleukin-10/Interleukin-5 responses at birth predict risk for respiratory infections in children with atopic family ...
M Kusel (10012535), PG Holt (14457411), A Bosco (13307889), K McKenna (9886307), G Zhang (7349387), PD Sly (14453628), J Rowe (9877307), N De Klerk (13369254)   +7 more
core  

Endothelial Cell Proteins as Biomarkers in Susac Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Susac syndrome (SS) is a rare CD8+ T cell–mediated microangiopathy affecting the brain, retina, and auditory labyrinth. Endothelial injury is thought to be a central mechanism; however, no circulating disease biomarkers are known. We performed targeted proteomic profiling to identify circulating endothelial‐associated proteins as ...
Rohit Benjamin, Yue Andy Qi, Ying Hao, Catherine DeMarino, Samuel Darko, Irene Cortese, Daniel S. Reich, María I. Gaitán, Steven Jacobson, Bridgett J. Billioux, Bryan Smith, Avindra Nath   +11 more
wiley   +1 more source

Systemic Reduction of Interleukin-4 or Interleukin-10 Fails to Reduce the Frequency or Severity of Experimental Cytomegalovirus Retinitis in Mice with Retrovirus-Induced Immunosuppression

, 2012
Interleukin-4 (IL-4) and interleukin-10 (IL-10) are key cytokines whose increased production during systemic HIV infection has been associated with decreased cellular immunity during AIDS.
Hsin Chien, Richard D. Dix, Emily L. Blalock   +2 more
core   +1 more source

Sex-dependent susceptibility to Listeria monocytogenes infection is mediated by differential interleukin-10 production [PDF]

, 2005
It is well documented that sex-dependent factors affect susceptibility to infection, with most mouse models demonstrating higher resistance in females.
Bastian Pasche, Helmut Fuchs, Andreas Lengeling, Hrabě de Angelis, M., Franz, T.J., Busch, D.H., Tobias J. Franz, Pasche, B., Busch, Dirk H, Busch, Dirk H., Kalaydjiev, S., Kremmer, E., Valérie Gailus-Durner, Martin Hrabé de Angelis, Kremmer, Elisabeth, Franz, Tobias J., De Angelis, Martin Hrabé, Pasche, Bastian, Dirk H. Busch, Lengeling, A., Fuchs, H., Fuchs, Helmut, Kalaydjiev, Svetoslav, Gailus-Durner, Valérie, Hrabé de Angelis, Martin, Lengeling, Andreas, Svetoslav Kalaydjiev, Gailus-Durner, V., Franz, Tobias J, Elisabeth Kremmer, Pasche, B;Kalaydjiev, S;Franz, TJ;Kremmer, E;Gailus-Durner, V;Fuchs, H;Hrabé de Angelis, M;Lengeling, A;Busch, DH, Pasche, B. ; Kalaydjiev, S. ; Franz, T.J. ; Kremmer, E. ; Gailus-Durner, V. ; Fuchs, H. ; Hrabé de Angelis, M. ; Lengeling, A. ; Busch, D.H.   +31 more
core   +1 more source

Impact of genomic risk factors on outcome after hematopoietic stem cell transplantation for patients with chronic myeloid leukemia

Haematologica, 2010
Background Non-HLA gene polymorphisms have been shown to influence outcome after allogeneic hematopoietic stem cell transplantation. Results were derived from heterogeneous, small populations and their value remains a matter of debate.Design and Methods ...
Anne M. Dickinson, Kim F. Pearce, Jean Norden, Stephen G. O’Brien, Ernst Holler, Heike Bickeböller, Yesilda Balavarca, Vanderson Rocha, Hans-Jochem Kolb, Ilona Hromadnikova, Petr Sedlacek, Dietger Niederwieser, Ronald Brand, Tapani Ruutu, Jane Apperley, Richard Szydlo, Els Goulmy, Wolfgang Siegert, Theo de Witte, Alois Gratwohl   +19 more
doaj   +1 more source

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source