Results 251 to 260 of about 499,069 (309)
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Leukemia Research, 1990
Interleukin 2 receptors (IL-2-R) are composed of (at least) two chains: the alpha chain (or p55 or Tac) and the beta chain (or p70 or p75). The association of both chains constitutes high affinity IL2-R complexes (Kd congruent to 10-100 pM), whereas the alpha-chain or the beta chain alone bind IL-2 with low (Kd congruent to 5-50 nM) and intermediate ...
M, Allouche +5 more
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Interleukin 2 receptors (IL-2-R) are composed of (at least) two chains: the alpha chain (or p55 or Tac) and the beta chain (or p70 or p75). The association of both chains constitutes high affinity IL2-R complexes (Kd congruent to 10-100 pM), whereas the alpha-chain or the beta chain alone bind IL-2 with low (Kd congruent to 5-50 nM) and intermediate ...
M, Allouche +5 more
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The Human Interleukin-2 Receptor
Annual Review of Immunology, 1986In 1976, Morgan et al first reported the presence of a T-cell growth promoting activity in the supernatants of activated T-cell cultures; they denoted this T-cell growth factor (TCGF) (1). In subsequent years, TCGF was characterized as a distinct biochemical entity and found to be a 15,500dalton glycoprotein (2).
W C, Greene, W J, Leonard
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The human interleukin-2 receptor
Journal of Cell Science, 1985ABSTRACT Complementary DNAs corresponding to the human receptor for interleukin-2 (IL-2) have been molecularly cloned, sequenced, and expressed in both COS-1 and L cells. The human genome appears to contain a single structural gene for this receptor located on the short arm of chromosome 10 (band 14-15).
W C, Greene +3 more
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Regulation of Interleukin 2 Receptor Expression by Interleukin 2
Scandinavian Journal of Immunology, 1986The regulatory influence of Interleukin 2 (IL‐2) on the expression of IL‐2 receptors (IL.‐2R) was studied using long‐term cultured T‐cell lines and recombinant IL‐2 (r‐IL‐2). Three T‐cell lines with different growth requirements were used as model systems: insulin‐specific BK‐BI‐1.2 cells express IL‐2R transiently after antigenic restimulation ...
A B, Reske-Kunz +3 more
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Interleukin 2/interleukin 2 receptor system in type 1 diabetes
Diabetes Research and Clinical Practice, 1989There is increasing evidence that cellular immune abnormalities are involved in the pathogenesis of type 1 diabetes mellitus. The non-obese diabetic (NOD) mouse, a model of human type 1 diabetes, develops mononuclear cell infiltration of its pancreatic islets (insulitis), leading to /3 cell destruction and overt diabetes [l]. In recent studies, most of
N, Hatamori +4 more
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1985
Interleukin-2 (IL-2) is a lymphokine synthesized by some T-cells following activation. Resting T-cells do not express IL-2 receptors but receptors are rapidly expressed on T-cells following the interaction of antigens, mitogens, or monoclonal antibodies with the antigen specific T-cell receptor complex.
Thomas A. Waldmann +6 more
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Interleukin-2 (IL-2) is a lymphokine synthesized by some T-cells following activation. Resting T-cells do not express IL-2 receptors but receptors are rapidly expressed on T-cells following the interaction of antigens, mitogens, or monoclonal antibodies with the antigen specific T-cell receptor complex.
Thomas A. Waldmann +6 more
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Interleukin-2 receptors in infectious mononucleosis
Immunology Letters, 1989The majority of peripheral blood mononuclear cells (PBMC) from acute-phase infectious mononucleosis (IM) patients express high levels of T10 (CD38) and HLA-DR surface antigens, which are markers characteristic of activated T cells. However, Tac antigen (p55) expression on these cells was not detectable by flow cytometric immunofluorescence, and only a ...
C, Schmidt +5 more
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Pathology, 1991
Following activation in vitro, peripheral blood mononuclear cells (PBMC) express cell-associated interleukin-2 receptors (IL2R). The present study was undertaken to define the proportion of T lymphocyte subsets that express the IL2R (CD25 antigen) upon different mitogenic stimulation.
Lai, FM, Leung, JCK, Lai, KN
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Following activation in vitro, peripheral blood mononuclear cells (PBMC) express cell-associated interleukin-2 receptors (IL2R). The present study was undertaken to define the proportion of T lymphocyte subsets that express the IL2R (CD25 antigen) upon different mitogenic stimulation.
Lai, FM, Leung, JCK, Lai, KN
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The released interleukin 2 receptor binds interleukin 2 efficiently.
The Journal of Immunology, 1986Abstract The released interleukin 2 receptor (IL 2R) molecule was characterized in order to clarify its biochemical structure and to determine its functional capacity. Enzymatic digestions demonstrated that the released IL 2R, like the cell surface IL 2R, is a complex glycoprotein, modified by the addition of both N- and O-linked ...
L A, Rubin, G, Jay, D L, Nelson
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INTERLEUKIN 2 RECEPTOR-DIRECTED IMMUNOSUPPRESSIVE THERAPY
1987An ideal antirejection therapy should, of course, be effective in controlling rejection as well as selectively target only those T-cells that are committed to participate in rejection of the donor graft. Conventional immunosuppressive drugs exact unwanted side effects upon non-lymphoid tissues. The introduction of monoclonal antibodies as pharmacologic
T. B. Strom +9 more
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