Results 271 to 280 of about 439,794 (317)

Biotinylated recombinant interleukin-2 a tool for research on the interleukin-2 receptor

Journal of Immunological Methods, 1989
Recombinant interleukin-2 was biotinylated using a N-hydroxyl-succinimidyl [3H]biotin ester. The biotinylated lymphokine retained full binding and growth-promoting activities when assayed on the interleukin-2-dependent murine cell line HT-2. In preliminary studies, biotinylated interleukin-2 was used in conjunction with immunogold staining to ...
B M, Foxwell, D, Taylor, B, Greiner, M J, Mihatsch, V, Olivieri, B, Ryffel   +5 more
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Interleukin-2 receptor expression and interleukin-2 production in bullous pemphigoid

Archives of Dermatological Research, 1990
Expression of interleukin-2 (IL2) receptors was studied on peripheral blood lymphocytes (PBLs) in 25 patients with bullous pemphigoid. Analysis was carried out by flow cytometry. Without immunosuppressive therapy expression of IL2 receptors only on T cells (CD5) was significantly increased as shown by double staining (11.9% +/- 7.8% vs 2.1% +/- 1% in ...
J, Schaller, T, Giese, M, Ladusch, U F, Haustein   +3 more
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Interleukin-2 and the interleukin-2 receptor complex

1990
Abstract Interleukin 2 (IL-2), originally designated as a T cell growth factor, is a glycoprotein with a molecular weight of 15.4 kD. The genes encoding the human, murine, and bovine IL-2 were cloned, their nucleotide sequences determined, and corresponding amino acid sequences deduced.-3 Human IL-2 consists of 133 amino acids and ...
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Soluble interleukin 2 receptor release, interleukin 2 production, and interleukin 2 receptor expression in activated T-lymphocytes in vitro

Pathology, 1991
Following activation in vitro, peripheral blood mononuclear cells (PBMC) express cell-associated interleukin-2 receptors (IL2R). The present study was undertaken to define the proportion of T lymphocyte subsets that express the IL2R (CD25 antigen) upon different mitogenic stimulation.
Lai, FM, Leung, JCK, Lai, KN
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Regulation of interleukin-2 receptor expression and receptor release

Molecular Immunology, 1986
The generation and cell surface expression of IL-2 receptors was monitored by: (i) an ELISA that permits quantitative determination of detergent-solubilized or soluble IL-2 receptors; and (ii) detection of the binding of 125I-labelled recombinant IL-2 and of anti-IL-2 receptor antibodies to receptor bearing cells.
T, Diamantstein, H, Osawa, A, Mouzaki, O, Josimovic-Alasevic   +3 more
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Serum Interleukin-2 and Soluble Interleukin-2 Receptor in Gestrational Trophoblastic Diseases

Journal of the Society for Gynecologic Investigation, 1996
To investigate serum interleukin-2 (IL-2) and soluble interleukin-2 receptor (SIL-2) levels in gestational trophoblastic diseases (GTD).Sixty-six patients with GTDs and 23 first-trimester healthy pregnant women (controls) participated in this study.
M, Shaarawy, N A, Darwish, O, Abdel-Aziz
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The bimolecular structure of the interleukin 2 receptor

Immunology Today, 1988
Abstract The structure of the receptors for interleukin 2 has recently been largely resolved, being composed of noncovalently linked 55 kDa and 75 kDa polypeptides. Here, Kendall Smith discusses how the low affinity binding sites present on these molecules combine to give rise to the single high affinity site found on normal T cells.
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The released interleukin 2 receptor binds interleukin 2 efficiently.

The Journal of Immunology, 1986
Abstract The released interleukin 2 receptor (IL 2R) molecule was characterized in order to clarify its biochemical structure and to determine its functional capacity. Enzymatic digestions demonstrated that the released IL 2R, like the cell surface IL 2R, is a complex glycoprotein, modified by the addition of both N- and O-linked ...
L A, Rubin, G, Jay, D L, Nelson
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SIGNALING DOMAINS OF THE INTERLEUKIN 2 RECEPTOR

Cytokine, 2001
Interleukin (IL-)2 and its receptor (IL-2R) constitute one of the most extensively studied cytokine receptor systems. IL-2 is produced primarily by activated T cells and is involved in early T cell activation as well as in maintaining homeostatic immune responses that prevent autoimmunity.
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THE SOLUBLE INTERLEUKIN‐2 RECEPTOR IN HAEMATOLOGICAL DISORDERS

British Journal of Haematology, 1987
Data on the clinical and biological role of sIL-"R detection in the sera of patients with a variety of hematological disorders have been provided and ...
Pizzolo G, Chilosi M, SEMENZATO, GIANPIETRO CARLO   +2 more
openaire   +4 more sources