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THE SOLUBLE INTERLEUKIN‐2 RECEPTOR IN HAEMATOLOGICAL DISORDERS
British Journal of Haematology, 1987Data on the clinical and biological role of sIL-"R detection in the sera of patients with a variety of hematological disorders have been provided and ...
Pizzolo G +2 more
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The interleukin-2/interleukin-2 receptor system: structural, immunological, and clinical features
International Journal of Clinical & Laboratory Research, 1992Interleukin-2 (IL-2) has been the first and more extensively studied cytokine, in particular for its central role in the mechanisms of cell growth and differentiation. The function of IL-2 is mediated through specific receptors (IL-2R) present on the membrane of reacting cells.
SEMENZATO, GIANPIETRO CARLO +2 more
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Regulation of interleukin-2 receptor expression and receptor release
Molecular Immunology, 1986The generation and cell surface expression of IL-2 receptors was monitored by: (i) an ELISA that permits quantitative determination of detergent-solubilized or soluble IL-2 receptors; and (ii) detection of the binding of 125I-labelled recombinant IL-2 and of anti-IL-2 receptor antibodies to receptor bearing cells.
Hisao Osawa +3 more
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SIGNALING DOMAINS OF THE INTERLEUKIN 2 RECEPTOR
Cytokine, 2001Interleukin (IL-)2 and its receptor (IL-2R) constitute one of the most extensively studied cytokine receptor systems. IL-2 is produced primarily by activated T cells and is involved in early T cell activation as well as in maintaining homeostatic immune responses that prevent autoimmunity.
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The bimolecular structure of the interleukin 2 receptor
Immunology Today, 1988Abstract The structure of the receptors for interleukin 2 has recently been largely resolved, being composed of noncovalently linked 55 kDa and 75 kDa polypeptides. Here, Kendall Smith discusses how the low affinity binding sites present on these molecules combine to give rise to the single high affinity site found on normal T cells.
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Biochemical and Biophysical Research Communications, 1993
Transfectants expressing the chimeric receptor which has human interleukin-4 receptor (hIL-4R) in the extracellular domain and human interleukin-2 receptor beta chain (hIL-2R beta) in the cytoplasmic domain showed continuous growth in response to human interleukin-4 (hIL-4), whereas transfectants expressing hIL-4R responded only transiently to hIL-4 ...
A. Miyajima, K. Izuhara, Nobuyuki Harada
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Transfectants expressing the chimeric receptor which has human interleukin-4 receptor (hIL-4R) in the extracellular domain and human interleukin-2 receptor beta chain (hIL-2R beta) in the cytoplasmic domain showed continuous growth in response to human interleukin-4 (hIL-4), whereas transfectants expressing hIL-4R responded only transiently to hIL-4 ...
A. Miyajima, K. Izuhara, Nobuyuki Harada
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Soluble interleukin-2 receptor in cancer
Frontiers in Bioscience, 2004Levels of serum sIL-2R (soluble interleukin-2 receptor) reflect the total amount of activated T lymphocytes in tumor infiltrating lymphocytes of cancer tissues and metastatic organs, because a part of alpha-chain of IL-2R is released into the bloodstream on the attachment of IL-2 (interleukin-2) to its specific IL-2R membrane.
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Biosensor analysis of the interleukin-2 receptor complex
Journal of Molecular Recognition, 1999Surface plasmon resonance (SPR) biosensor technology has been a significant addition to the evolution and refinement of methods to study macromolecular interactions. Prior to the advent of SPR, we employed a variety of biochemical and biological techniques to study the interleukin-2/interleukin-2 receptor system (IL-2/IL-2R). By combining site-directed
Thomas L. Ciardelli +2 more
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Prolonged elevations of soluble interleukin-2 receptors in tuberculosis.
, 1989In order to determine whether tuberculosis is associated with elevated levels of soluble interleukin-2 receptors (SIL-2R), patients with both pulmonary (n = 12) and extrapulmonary (n = 8) disease were studied. SIL-2R were measured in sera using an enzyme-
Brown Ae, Rieder Kt, Webster Hk
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Immune disturbances during major depression: upregulated expression of interleukin-2 receptors.
Neuropsychobiology, 1990We determined the following immune parameters in drug-free, major depressed patients and in age- and sex-matched healthy controls: the number and percentage of interleukin-2 receptor (IL-2R) bearing cells (CD25+, anti-TAC), serum circulating levels of ...
M. Maes +5 more
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