Results 31 to 40 of about 1,113,949 (291)
Structure-function relationships for the interleukin 2 receptor system
Memorias do Instituto Oswaldo Cruz, 1987 Receptors for interleukin 2 (IL-2) esit in at least three forms which differ in their subunit compositio, their affinity for ligand and their ability to mediate a cellular reponse.
Richard J. Robb
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Targeted Activation of T Cells with IL-2-Coupled Nanoparticles
Cells, 2020 Interleukin-2 (IL-2) is a T cell growth factor particularly required in regulatory T cell maintenance and memory T cell responses. High-dose IL-2 treatment was the first FDA-approved immunotherapy for cancer, while low-dose IL-2 administration has shown ...
Verena K. Raker +3 more
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European Journal of Inflammation, 2021 Human breast milk (HBM) contains many bioactive components that protect infants from various microorganisms. Pattern recognition receptors on phagocytic cells recognize microbial pathogens and promote the innate immune system.
Won-Ho Hahn +3 more
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The Turkish Journal of Pediatrics, 2019 Activation of the humoral immune response in newborns` multiple organ failure syndrome is associated with the production of interleukin-1β, which is recognized via Toll-like receptors 2 (TLR2).
Dmytro A Shkurupii
doaj +1 more source
Only high-affinity receptors for interleukin 2 mediate internalization of ligand.
Proceedings of the National Academy of Sciences of the United States of America, 1986 Interleukin 2 (IL-2) receptors are expressed on activated T cells and in select T-cell leukemias. Recently, it has been demonstrated that at least two classes of receptor for IL-2 exist with markedly different affinities for ligand.
A. Weissman +7 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 1987 Interleukin 2 (IL-2) receptors on activated T cells exist in high- and low-affinity configurations, both of which share a ligand-binding component known as the Tac protein. Although almost all binding of IL-2 to such cells was inhibited by an antibody to
R. Robb, C. M. Rusk, J. Yodoi, W. Greene
semanticscholar +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Regulation of interleukin 2 receptors on T cells from multiple sclerosis patients.
Proceedings of the National Academy of Sciences of the United States of America, 1986 Receptors for interleukin 2 (IL-2) are absent on resting T lymphocytes and are induced by antigenic and mitogenic stimulation. After a limited time (8-12 days), these receptors on normal T cells are down-regulated despite the presence of receptor ...
E. Defreitas +4 more
semanticscholar +1 more source
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
Blood, 1985 The role of interleukin 2 (IL 2) as a possible regulator of in vitro proliferation and differentiation of non-T acute lymphoblastic leukemia (ALL) cells was investigated.
I. Touw +4 more
semanticscholar +1 more source