Results 31 to 40 of about 465,939 (309)

Algebraic study of receptor-ligand systems: a dose-response analysis [PDF]

arXiv, 2022
The study of a receptor-ligand system generally relies on the analysis of its dose-response (or concentration-effect) curve, which quantifies the relation between ligand concentration and the biological effect (or cellular response) induced when binding its specific cell surface receptor.
arxiv  

Inflammation as a Central Mechanism in Alzheimer\u27s Disease [PDF]

, 2018
Alzheimer\u27s disease (AD) is a progressive neurodegenerative disorder that is characterized by cognitive decline and the presence of two core pathologies, amyloid β plaques and neurofibrillary tangles.
Bemiller, Shane M., Kinney, Jefferson W., Lamb, Bruce T., Leisgang, Amanda M., Murtishaw, Andrew S., Salazar, Arnold M.   +5 more
core   +2 more sources

Method for identification of condition-associated public antigen receptor sequences [PDF]

eLife 2018;7:e33050, 2017
Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences.
arxiv   +1 more source

Reduction of circulating cholesterol and apolipoprotein levels during sepsis [PDF]

, 1999
Sepsis with multiple organ failure is frequently associated with a substantial decrease of cholesterol levels. This decrease of cholesterol is strongly associated with mortality suggesting a direct relation between inflammatory conditions and altered ...
Alvarez C, Chajek-Shaul T, Engelmann H, Ettinger WH, Ettinger WH, Ettinger WH, Feingold KR, Feingold KR, Flegel WA, Gouni I, Graham A, Greenberg AS, Grove RI, Grunfeld C, Hubsch AP, Ishibashi S, Kipp HA, Moran CS, Netea MG, Pacelli F, Pak YK, Read TE, Semb H, Stopeck AT, Van Gameren MM, Weinstock C, Wilson DE, Yokoyama K   +27 more
core   +1 more source

Regulation of Neuromodulator Receptor Efficacy - Implications for Whole-Neuron and Synaptic Plasticity [PDF]

Progress in Neurobiology 72(6), pp 399-415, April 2004, 2004
Membrane receptors for neuromodulators (NM) are highly regulated in their distribution and efficacy - a phenomenon which influences the individual cell's response to central signals of NM release. Even though NM receptor regulation is implicated in the pharmacological action of many drugs, and is also known to be influenced by various environmental ...
arxiv   +1 more source

Effect of human breast milk on innate immune response: Up-regulation of bacterial pattern recognition receptors and innate cytokines in THP-1 monocytic cells

European Journal of Inflammation, 2021
Human breast milk (HBM) contains many bioactive components that protect infants from various microorganisms. Pattern recognition receptors on phagocytic cells recognize microbial pathogens and promote the innate immune system.
Won-Ho Hahn, Soon Young Shin, Jun Hwan Song, Nam Mi Kang   +3 more
doaj   +1 more source

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

Cellular Physiology and Biochemistry, 2013
Depression is a multicausal disorder and has been associated with the risk to develop cancer, dementia, diabetes, epilepsy and stroke. As a metabolic disorder depression has been associated with obesity, diabetes, insulin sensitivity, neuropeptide Y ...
Undine E. Lang, Stefan Borgwardt
doaj   +1 more source

Expression of the Toll-like receptors 2 gene as a genetic determinant of the formation of newborns multiple organ failure syndrome

The Turkish Journal of Pediatrics, 2019
Activation of the humoral immune response in newborns` multiple organ failure syndrome is associated with the production of interleukin-1β, which is recognized via Toll-like receptors 2 (TLR2).
Dmytro A Shkurupii
doaj   +1 more source

Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism [PDF]

, 2011
SummaryIn cytotoxic T cells (CTL), Akt, also known as protein kinase B, is activated by the T cell antigen receptor (TCR) and the cytokine interleukin 2 (IL-2). Akt can control cell metabolism in many cell types but whether this role is important for CTL
Ahmed, Andrew N. Macintyre, Araki, Bachmann, Bain, Bayascas, Bayascas, Carlson, Carmen Feijoo, Caryll M. Waugh, Castellino, Cham, Cornish, Cruz-Guilloty, D'Souza, David Finlay, Doreen A. Cantrell, Fabre, Finlay, Fox, Garçon, Gavin Preston, Green, Hand, Hendriks, Jacobs, Janas, Jarmin, Juntilla, Kaech, Kalia, Kelly, Kerdiles, Klaus Okkenhaug, Kurts, Lin, Linda V. Sinclair, Liu, Maciver, Malek, Manjunath, Mao, Obar, Ouyang, Pearce, Peter Tamas, Pipkin, Pircher, Prlic, Rao, Rathmell, Saeed, Saibil, Sinclair, Soond, Tamás, Waugh, Williams, Williams   +58 more
core   +3 more sources

Increased accuracy of ligand sensing by receptor diffusion on cell surface [PDF]

Physical Review E 82, 041902 (2010), 2010
The physical limit with which a cell senses external ligand concentration corresponds to the perfect absorber, where all ligand particles are absorbed and overcounting of same ligand particles does not occur. Here we analyze how the lateral diffusion of receptors on the cell membrane affects the accuracy of sensing ligand concentration.
arxiv   +1 more source