Results 41 to 50 of about 439,794 (317)

Effect of human breast milk on innate immune response: Up-regulation of bacterial pattern recognition receptors and innate cytokines in THP-1 monocytic cells

European Journal of Inflammation, 2021
Human breast milk (HBM) contains many bioactive components that protect infants from various microorganisms. Pattern recognition receptors on phagocytic cells recognize microbial pathogens and promote the innate immune system.
Won-Ho Hahn, Soon Young Shin, Jun Hwan Song, Nam Mi Kang   +3 more
doaj   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

Cellular Physiology and Biochemistry, 2013
Depression is a multicausal disorder and has been associated with the risk to develop cancer, dementia, diabetes, epilepsy and stroke. As a metabolic disorder depression has been associated with obesity, diabetes, insulin sensitivity, neuropeptide Y ...
Undine E. Lang, Stefan Borgwardt
doaj   +1 more source

Characterisation of bovine leukocyte Ig-like receptors

, 2012
Leukocyte Immunoglobulin-like receptors (LILR) are innate immune receptors involved in regulating both innate and adaptive immune functions. LILR show more interspecies conservation than the closely related Killer Ig-like receptors, and homologues have ...
Laing Ken, Martin Vordermeier, John Trowsdale, Singh Mahavir, Philip Butcher (173962), Allen Rachel L., Ken Laing, Laing, K, Butcher, P, Mahavir Singh, Des C Jones, Butcher, Philip, Bhuju, S, Ken Laing (173955), Vordermeier, M, Singh, Mahavir, Jones, DC, Trowsdale, John, Mahavir Singh (70735), Rachel L Allen, Hogan, Louise, Trowsdale, J, Hogan Louise, Vordermeier Martin, Hogan, L, Philip Butcher, Singh, M, Allen, RL, Des C. Jones (173949), Louise Hogan (173942), John Trowsdale (1225), Martin Vordermeier (108962), Trowsdale John, Vordermeier, Martin, Allen, Rachel L, Jones Des C., Sabin Bhuju, Laing, Ken, Bhuju Sabin, Sabin Bhuju (107606), Rachel L. Allen (173972), Jones, Des C, Bhuju, Sabin, Louise Hogan, Butcher Philip   +44 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Expression of the Toll-like receptors 2 gene as a genetic determinant of the formation of newborns multiple organ failure syndrome

The Turkish Journal of Pediatrics, 2019
Activation of the humoral immune response in newborns` multiple organ failure syndrome is associated with the production of interleukin-1β, which is recognized via Toll-like receptors 2 (TLR2).
Dmytro A Shkurupii
doaj   +1 more source

Natriuretic peptide receptors on rat thymocytes: Inhibition of proliferation by atrial natriuretic peptide. [PDF]

, 1996
Because the thymus expresses the natriuretic peptides (NP) as well as their respective receptors, an involvement of NP in the physiology of this organ has been suggested.
Schmidt, Karin-Nicole, Vollmar, Angelika M., Schulz, Rüdiger, A. M. Vollmar   +3 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source