Results 61 to 70 of about 439,794 (317)

Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors. [PDF]

, 2013
Recent investigations have revealed that the genetic deletion of P2X7 receptors (P2rx7) results in an antidepressant phenotype in mice. However, the link between the deficiency of P2rx7 and changes in behavior has not yet been explored.
Zsilla Gabriella, Csölle Cecília, Csölle, Cecília, Illes Peter, Flóra Gölöncsér, Gabriella Zsilla, Mária Baranyi, Sperlágh, Beáta, Baranyi, Mária, Kittel Ágnes, Peter Illes, Baranyi Mária, Beáta Sperlágh, Vizi E. Szilveszter, E Sylvester Vizi, Zsilla, Gabriella, Papp Edit, Gölöncsér Flóra, Illés, Péter, Gölöncsér, Flóra, E. Sylvester Vizi, Sperlágh Beáta, Illes P, Vizi, E. Szilveszter, Papp, Edit, Edit Papp, Kittel, Ágnes, Agnes Kittel, Cecilia Csölle, Vizi E. Sylvester   +29 more
core   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Synergy between sphingosine 1-phosphate and lipopolysaccharide signaling promotes an inflammatory, angiogenic and osteogenic response in human aortic valve interstitial cells.

PLoS ONE, 2014
Given that the bioactive lipid sphingosine 1-phosphate is involved in cardiovascular pathophysiology, and since lipid accumulation and inflammation are hallmarks of calcific aortic stenosis, the role of sphingosine 1-phosphate on the pro-inflammatory/pro-
Isabel Fernández-Pisonero, Javier López, Esther Onecha, Ana I Dueñas, Patricia Maeso, Mariano Sánchez Crespo, José Alberto San Román, Carmen García-Rodríguez   +7 more
doaj   +1 more source

Low-power laser irradiation suppresses inflammatory response of human adipose-derived stem cells by modulating intracellular cyclic AMP level and NF-κB activity. [PDF]

PLoS ONE, 2013
Mesenchymal stem cell (MSC)-based tissue regeneration is a promising therapeutic strategy for treating damaged tissues. However, the inflammatory microenvironment that exists at a local injury site might restrict reconstruction.
Jyun-Yi Wu, Chia-Hsin Chen, Chau-Zen Wang, Mei-Ling Ho, Ming-Long Yeh, Yan-Hsiung Wang   +5 more
doaj   +1 more source

Modulation of human immune responses by bovine interleukin-10

, 2011
Cytokines can be functionally active across species barriers. Bovine IL-10 has an amino acid sequence identity with human IL-10 of 76.8%. Therefore, the aim of this study was to evaluate whether bovine IL-10 has immunomodulatory activities on human ...
Schoemaker, R., de Ruiter, T., Weg-Schrijver, Elise, van de, Westphal Adrie H., Tijhaar, E., Savelkoul, H.F.J., Adrie H Westphal, Westphal, A.H., Savelkoul Huub F. J., R J Joost van Neerven, Edwin Tijhaar, Neerven, R.J.J., van, Gerco den Hartog, van de Weg-Schrijver Elise, Schoemaker Ruud, den Hartog Gerco, den Hartog, C.G., Huub F J Savelkoul, van de Weg-Schrijver, Elise, Talitha de Ruiter, Elise van de Weg-Schrijver, de Ruiter Talitha, Ruiter, T., de, Ruud Schoemaker, van Neerven, R.J.J., Hartog, C.G., den, Tijhaar Edwin, van Neerven R. J. Joost   +27 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Plasma levels of immunoinflammatory markers in De Novo coronary atherosclerosis and coronary restenosis postangioplasty

Arquivos Brasileiros de Cardiologia, 2001
OBJECTIVE: To compare circulating plasma levels of immunoinflammatory markers in patients with known de novo coronary artery disease and patients with postangioplasty restenosis.
Alexandre Schaan de Quadros, Jorge Pinto Ribeiro, Waldomiro Carlos Manfroi, Cristiane Leitão, Karen Ordovás, Letícia Weiss, Nadine Clausell   +6 more
doaj   +1 more source

Chia seeds oil ameliorate chronic immobilization stress-induced neurodisturbance in rat brains via activation of the antioxidant/anti-inflammatory/antiapoptotic signaling pathways

Scientific Reports, 2023
Chronic immobilization stress plays a key role in several neuropsychiatric disorders. This investigation assessed the possible ameliorative effect of chia seed oil (CSO) against the neurodisturbance-induced in rats by chronic immobilization.
Norhan E. Khalifa, Ahmed E. Noreldin, Asmaa F. Khafaga, Mohamed El-Beskawy, Eman Khalifa, Ali H. El-Far, Abdel-Hasseb A. Fayed, Abdeldayem Zakaria   +7 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Neopterin, soluble receptors for interleukin-2 and tumor necrosis factor in viral cirrhosis and alcoholic cirrhosis

Pteridines, 2000
Alcoholic cirrhosis and viral cirrhosis are associated with alterations of immune system function and cytokine production. Our aim was to investigate whether serum concentrations of soluble receptors for interleukin-2 (sIL- 2 R) and tumor necrosis factor
Gonzalez-Calvin Jorge, Tilz Gernot P., Gallego-Rojo Francisco, Torres-Almendros Marina, Widner Bernhard, Diez-Ruiz Antonio, Rico-Irles José, Fuchs Dietmar   +7 more
doaj   +1 more source