Results 81 to 90 of about 113,043,833 (209)

ELR+ CXC chemokine signalling in cartilage homeostasis. [PDF]

, 2011
PhDThe production of ELR+ CXC chemokines is widely studied in arthritis and has been postulated to contribute to the inflammatory phenomena that eventually lead to cartilage breakdown.
Sherwood, Joanna
core   +2 more sources

EP 4 receptors mediate prostaglandin E 2, tumour necrosis factor alpha and interleukin 1beta-induced ion secretion in human and mouse colon mucosa

, 2012
EP 4 receptors mediate prostaglandin E 2, tumour necrosis factor alpha and interleukin 1beta-induced ion secretion in human and mouse colon ...
SE Fairbrother (14474910), HM Cox (14474847), JE Smith (7757447), RA Borman (14474913)   +3 more
core  

Interleukin-2 and its receptors: Implications and therapeutic prospects in immune-mediated disorders of central nervous system

Pharmacological Research
Interleukin-2 (IL-2), the first cloned cytokine, is a multifunctional molecule with diverse cellular origins. As a pivotal T-cell growth factor, IL-2 is crucial for T-cell proliferation and the generation of effector and memory cells.
Yiwei Zhang, Qi Kong, Junfen Fan, Haiping Zhao   +3 more
doaj   +1 more source

Multiple P2Y receptors couple to calcium-dependent, chloride channels in smooth muscle cells of the rat pulmonary artery [PDF]

, 2005
Uridine 5'-triphosphate (UTP) and uridine 5'-diphosphate (UDP) act via P2Y receptors to evoke contraction of rat pulmonary arteries, whilst adenosine 5'-triphosphate (ATP) acts via P2X and P2Y receptors.
Chootip, Krongkarn, Kennedy, Charles, Gurney, Alison M.   +2 more
core   +1 more source

Interactions of intestinal epithelial cells with bacterial extracellular products [PDF]

The enteric microflora represents one of the densest microbial populations in the biological world; as a consequence, the intestinal immune system is constantly exposed to high concentrations of antigenic materials. One of the major frontline defences in
Patten, Daniel
core   +1 more source

Advanced cytokine-based immunotherapies: targeted cis-delivery strategies for enhanced anti-tumor efficacy and reduced toxicity

mAbs
First-generation cancer immunotherapies, such as high-dose interleukin-2 (IL-2), have demonstrated clinical efficacy, but are limited by significant systemic toxicities due to their broad expression of cytokine receptors.
Laurène Pousse, Amrita Manchala, Christian Klein, Laura Codarri Deak   +3 more
doaj   +1 more source

Associação de polimorfismos em genes envolvidos na regulação da atividade das células NK (Natural Killer) no desenvolvimento do câncer de mama [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biologia Celular e do Desenvolvimento, Florianópolis, 2014.Introdução: O câncer de mama possui etiologia variada, sendo influenciada ...
Back, Lia Kubelka de Carlos
core  

Post-transcriptional effects of interleukin-3, interferon-gamma, erythropoietin and butyrate on in vitro hemoglobin chain synthesis in congenital hemolytic anemia

Haematologica, 2001
BACKGROUND AND OBJECTIVES: Various agents modulate hemoglobin synthesis. In vitro modulation of translation in hemoglobin chain synthesis was analysed in patients with congenital hemolytic anemia (n=32) and healthy controls (n=17).
D Reinhardt, R Ridder, W Kugler, A Pekrun   +3 more
doaj  

Single‐cell analysis of tumor microenvironment and cell adhesion reveals that interleukin‐1 beta promotes cancer cell proliferation in breast cancer

Animal Models and Experimental Medicine
Background Triple‐negative breast cancer (TNBC), which is so called because of the lack of estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptor 2 (HER2) receptors on the cancer cells, accounts for 10%–15% of ...
Wenyan Wang, Gehong Dong, Ziguo Yang, Shaoxiang Li, Jia Li, Lin Wang, Qiang Zhu, Yuchen Wang   +7 more
doaj   +1 more source

Macrophage-P2X4 receptors pathway is essential to persistent inflammatory muscle hyperalgesia onset, and is prevented by physical exercise.

PLoS ONE
Peripheral inflammation may lead to severe inflammatory painful conditions. Macrophages are critical for inflammation; modulating related pathways could be an essential therapeutic strategy for chronic pain diseases.
Graciana de Azambuja, Fernando Moreira Simabuco, Maria Cláudia Gonçalves de Oliveira   +2 more
doaj   +1 more source