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Molecular cloning and expression of the human interleukin 5 receptor

, 1993
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Interleukin 5 and its receptor

Progress in Growth Factor Research, 1991
IL-5 is a cytokine mainly produced by T lymphocytes, especially when they are sensitized with microorganisms, which induce eosinophils and Ly-1 positive B lineage cells, both of which are probably engaged in the primary protection against micro-organisms. These possibilities are discussed by analyzing IL-5 transgenic mice.
K, Takatsu, A, Tominaga
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The Biology of Interleukin-5 and Its Receptor

Cancer Investigation, 1993
IL-5 is primarily a T-cell-derived cytokine that has multiple regulatory functions on eosinophils and (in the mouse) on antibody-secreting B cells. A complex network of cytokines appear to control transcription of the gene for IL-5 and its production. Abnormally high levels of this cytokine are associated with infections with tissue-dwelling parasites ...
S, Mahanty, T B, Nutman
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Cytokine Recognition by Human Interleukin 5 Receptor

2005
The activation of interleukin 5 (IL-5) receptor is a dynamic process that depends on specific interaction of IL-5 with IL-5 receptor alpha, the formation of oligomeric receptor complexes with receptor beta, and the initiation of cytoplasmic phosphorylation events. These steps culminate in the triggering of a cellular response.
Tetsuya, Ishino, Noreen, Robertson, Irwin, Chaiken   +2 more
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Structure-Based Rationale for Interleukin 5 Receptor Antagonism

Current Pharmaceutical Design, 2008
Human interleukin 5 (IL5) is the major hematopoietin that stimulates the proliferation, migration and activation of eosinophils and is implicated in the pathogenesis of inflammatory and other myeloproliferative diseases. IL5 functions through the signaling of a common receptor subunit beta (beta c), in a receptor activation process that requires ...
Tetsuya, Ishino, Adrian E, Harrington, Hosahudya, Gopi, Irwin, Chaiken   +3 more
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Recruitment pharmacophore for interleukin 5 receptor α antagonism

Peptide Science, 2006
AbstractInterleukin‐5 receptor α is a therapeutic target for hypereosinophilic diseases including allergic inflammations and asthma. The cyclic peptide AF17121 (Ac‐VDE[CWRIIASHTWFC]AEE‐CONH2) has been identified as a submicromolar inhibitor of interleukin 5 (IL5)‐interleukin 5 receptor α (IL5Rα) interaction from a random peptide screen.
Madhushree, Bhattacharya, Udaya, Pillalamari, Sanjay, Sarkhel, Tetsuya, Ishino, Cecilia, Urbina, Bradford, Jameson, Irwin, Chaiken   +6 more
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Biological and Molecular Characteristics of Interleukin-5 and its Receptor

International Reviews of Immunology, 1998
Interleukin-5 (IL5) is a T cell-derived cytokine involved in the pathogenesis of atopic diseases. It specifically controls the production, the activation and the localization of Eosinophils. The Eosinophils are the major cause of tissue damage resulting in the symptoms of asthma and related allergic disorders.
S, Karlen, M L, De Boer, R J, Lipscombe, W, Lutz, V A, Mordvinov, C J, Sanderson   +5 more
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The Interleukin-5 Receptor

1995
Abstract The nucleotide sequence of the human IL-5Ra cDNA (GenBank accession numbers M75914, M96651, M96652, X61176, X61177, X61178, and X62156) predicts a polypeptide of 420 amino acids (Fig. 1) (Tavernier et al. 1991, 1992; Murata et al. 1992).
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Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor

International Immunopharmacology, 2002
Interleukin-5 (IL-5) plays an important role in the activation of eosinophils in allergic inflammation including asthma and atopic dermatitis. A newly synthesized compound, YM-90709, 2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo[7,8]indolizino [2,3-b]quinoxaline, is reported here to inhibit the binding of IL-5 to its receptor on peripheral human ...
Tatsuaki, Morokata, Kenji, Ida, Toshimitsu, Yamada   +2 more
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Analysis of interleukin 5 receptors on murine eosinophils: A comparison with receptors on B13 cells

Cytokine, 1991
The interleukin 5 receptor (IL-5R) on murine eosinophils and a mouse B cell line (B13) was investigated using iodinated murine IL-5 produced in the baculovirus system. Electrophoretic analysis of this recombinant protein identified a range of bands Mr 26,000 to 32,000 resulting from differential glycosylation. The specific activity and binding kinetics
S C, Barry, A N, McKenzie, M, Strath, C J, Sanderson   +3 more
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