Results 1 to 10 of about 12,528,653 (292)

Prostaglandin D2 and Interleukin-5 Reduce Crth2 Surface Expression on Human Eosinophils

Allergology International, 2004
Background: Recently, a second prostaglandin D2 (PGD2) receptor, chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2), was identified.
Kazuyuki Hamada, Yoshiyuki Yamada, Yumiko Kamada, Shigeharu Ueki, Kazutoshi Yamaguchi, Hajime Oyamada, Miyoshi Fujita, Atsuko Usami, Takahito Chiba, Akira Kanda, Hiroyuki Kayaba, Junichi Chihara   +11 more
doaj   +1 more source

Pulmonary biology of anti-interleukin 5 antibodies

Memorias do Instituto Oswaldo Cruz, 1997
Interleukin 5 (IL-5) is a critical cytokine for the maturation of eosinophil precursors to eosinophils in the bone marrow and those eosinophils then accumulate in the lungs during asthma. We have studied anti IL-5 antibodies on allergic responses in mice,
RW Egan, D Athwahl, C-C Chou, RW Chapman, S Emtage, C-H Jenh, TT Kung, PJ Mauser, NJ Murgolo, MW Bodmer   +9 more
doaj   +1 more source

Pulmonary tuberculosis: evaluation of interferon-gamma levels as an immunological healing marker based on the response to the Bacillus Calmette-Guerin

Memorias do Instituto Oswaldo Cruz, 2004
Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis whose interaction with the host may lead to a cell-mediated protective immune response. The presence of interferon-g (IFN-gamma) is related to this response.
EP Moura, VPCP Toledo, MHP Oliveira, S Spíndola-de-Miranda, HM Andrade, TMPD Guimarães   +5 more
doaj   +1 more source

Uncovering how interleukin-5 and interleukin-23 shape human immune defense against Salmonella enterica Typhi

Journal of Microbiology and Infectious Diseases
Background: Salmonella enterica serotype Typhi remains a major global health concern, particularly in regions with limited resources. Interleukins such as interleukin-5 and interleukin-23 are thought to play pivotal roles in shaping the host's ...
Ruaa Kareem Surhan, Aqeel A. Al-Sadawi, Ali Reyadh Medhat, Ahmed Al Obaidi   +3 more
doaj   +1 more source

Mepolizumab in Chronic Obstructive Pulmonary Disease (COPD): A new frontier in biologic therapy

Saudi Journal of Anaesthesia
Mepolizumab, a comprehensible monoclonal antibody that inhibits interleukin-5 (IL-5), offers a new therapeutic option for a subset of patients with chronic obstructive pulmonary disease (COPD) marked by eosinophilic inflammation.
Arun Mukesh, Konica Chittoria, Ankur Sharma   +2 more
doaj   +1 more source

Mepolizumab for hypereosinophilic syndrome: effectiveness and safety from real-world evidence

Frontiers in Immunology
Hypereosinophilic syndrome (HES) is a rare condition characterized by elevated eosinophil levels and related symptoms of eosinophil-mediated organ damage. We reviewed the effectiveness and safety of mepolizumab for the treatment of HES.
Elvira Mora, María Laura Fox, María Laura Fox, Angelina Lemes, Beatriz Velasco, Jesús María Hernández-Rivas, Jesús María Hernández-Rivas   +6 more
doaj   +1 more source

Role of eosinophils in protective immunity against secondary nematode infections

Immunological Medicine, 2019
Infections with parasites, especially those involving nematodes that invade tissues, induce a strong Th2-type immune response, which increases immunoglobulin E and eosinophil levels in the blood and tissues.
Koubun Yasuda, Etsushi Kuroda
doaj   +1 more source

IL-5, IL-31 and systemic immune-inflammation index as biomarkers predicting severity and progression in bullous pemphigoid

Frontiers in Medicine
IntroductionInflammatory mechanisms assume a pivotal role in bullous pemphigoid (BP). IL-31, IL-5, and the systemic immunoinflammatory index (SII) are emerging markers of inflammatory activity, but their associations with BP severity remain unclear. This
Yanyu Zhang, Xia Liu, Lili Hou, Yan Zhao, Jiaxuan Hao, Na Zhang, Jing Tian, Xiaoqing Li, Zhiyu Liu, Hongwei Zhou, Chunyang Xu, Yuan Ren, Haizhou Zhou   +12 more
doaj   +1 more source

Interleukin‐5, Eosinophils, and Interleukin‐5 Pathway Inhibitors in Eosinophilic Granulomatosis With Polyangiitis

Arthritis & Rheumatology
Interlukin‐5 (IL‐5) plays a crucial role in the pathogenesis of eosinophilic granulomatosis with polyangiitis (EGPA) by promoting eosinophil differentiation, activation, and survival. We present here a typical case of EGPA in which treatment with IL‐5 pathway inhibitors is prescribed, showing to be beneficial for the patient.
Alvise, Berti, Christian, Pagnoux
openaire   +2 more sources

Does Eosinophil Heterogeneity Translate into Functional Diversity? A Review of the Evolving Paradigm of Eosinophil Heterogeneity in Asthma

Biomedicines
This review provides an overview of evidence supporting the existence of distinct homeostatic and inflammatory eosinophil subpopulations in health and disease.
Gabriella E. Wilson, Samir Gautam, Geoffrey L. Chupp   +2 more
doaj   +1 more source