Results 11 to 20 of about 7,367 (214)

Interplay Between the IL-33/ST2 Axis and Bone Marrow ILC2s in Protease Allergen-Induced IL-5-Dependent Eosinophilia

Frontiers in Immunology, 2020
Background: Eosinophils develop from CD34+ progenitor cells in the bone marrow under the influence of interleukin (IL)-5. Several cell types produce IL-5, including type 2 innate lymphoid cells (ILC2s).
Emma Boberg, Kristina Johansson, Carina Malmhäll, Jenny Calvén, Julie Weidner, Madeleine Rådinger   +5 more
doaj   +1 more source

Anti-IL5 Drugs in COVID-19 Patients: Role of Eosinophils in SARS-CoV-2-Induced Immunopathology

Frontiers in Pharmacology, 2021
SARS-CoV-2 infection stimulates a complex activation of the immune system. Eosinophils belong to the host’s defense equipment against respiratory viruses.
Daniele Pala, Daniele Pala, Marco Pistis, Marco Pistis   +3 more
doaj   +1 more source

Episodic angioedema associated with eosinophilia [PDF]

Anais Brasileiros de Dermatologia, 2017
: We report a 12-year-old girl who presented with recurrent angioedema on the face, trunk, and extremities, and concomitant marked weight gain for 5 years.
Fang Liu, Wenxing Hu, Haibo Liu, Min Zhang, Hong Sang   +4 more
doaj   +1 more source

Mepolizumab in the treatment of bronchial asthma in children

Медицинский совет, 2020
Severe bronchial asthma in children remains a serious problem, which is due to the high risk of mortality, side effects of therapy with high doses of glucocorticosteroids, significant consumption of health resources.
Yu. L. Mizernitskiy, I. M. Mel'nikova, V. A. Pavlenko   +2 more
doaj   +1 more source

Biological functions and clinical efficacy of IL-5/IL-5Rα-targeted therapies across eosinophilia-associated diseases

Frontiers in Immunology
Interleukin-5 (IL-5) is a central regulator of eosinophil differentiation, maturation, survival, activation, and mobilization, and it contributes to eosinophil recruitment to inflamed tissues.
Johannes Lübke, Andreas Reiter, Juliana Schwaab   +2 more
doaj   +1 more source

Interleukin-5 Mediates Parasite-Induced Protection against Experimental Autoimmune Encephalomyelitis: Association with Induction of Antigen-Specific CD4+CD25+ T Regulatory Cells

Frontiers in Immunology, 2017
ObjectiveTo examine if the protective effect of parasite infection on experimental autoimmune encephalomyelitis (EAE) was due to interleukin (IL)-5, a cytokine produced by a type-2 response that induces eosinophilia.
Giang T. Tran, Paul L. Wilcox, Lindsay A. Dent, Catherine M. Robinson, Nicole Carter, Nirupama D. Verma, Bruce M. Hall, Suzanne J. Hodgkinson   +7 more
doaj   +1 more source

Short-term stimulation with interleukin (IL)-4 enhances purified protein derivative-induced production of an eosinophil chemotactic lymphokine, but suppresses IL-5 production

Allergology International, 1998
The effect of interleukin (IL)-4 on eosinophil chemotactic lymphokine (ECL) production from peripheral blood mononuclear cells (PBMC) stimulated with purified protein derivative (PPD) was examined.
Takehiko Nishiyama, Taishi Hata, Hiroki Okada, Mitsuomi Hiroshima   +3 more
doaj   +1 more source

Covalent modification of the interleukin‐5 receptor by isothiazolones leads to inhibition of the binding of interleukin‐5 [PDF]

European Journal of Biochemistry, 1994
Using a fusion protein of the human interleukin‐5‐receptor α chain (hILSRα) and the human IgG Cγ3 chain (hIL5Rα‐hγ3), we have developed a solid‐phase assay for high‐flux screening of a collection of synthetic compounds. We report on the identification of isothiazolone derivatives as potent inhibitors of binding of interleukin‐5 (IL5) to the hIL5Ra, as ...
R, Devos, Y, Guisez, G, Plaetinck, S, Cornelis, J, Tavernier, J, van der Heyden, L H, Foley, J E, Scheffler   +7 more
openaire   +2 more sources

Modulation by IL-10 of antigen-induced allergic responses in mice

Memorias do Instituto Oswaldo Cruz, 1997
Over the last few years, we examined the anti-allergic properties of interleukin (IL)-10 in different models of inflammation in the mouse, as well as against IgE-dependent activation of mouse bone marrow-derived mast cells (BMMC).
Claudia Zuany-Amorim, B Boris Vargaftig, Marina Pretolani   +2 more
doaj   +1 more source

Expression level of micro-RNA-1, IL-5, IFNγ, and TNFα in adult-onset asthmatic patients

Egyptian Journal of Chest Disease and Tuberculosis, 2021
Background and objective Asthma is an inflammatory process, where T lymphocytes cells, mainly the Th1/Th2 cells, participate in bronchial asthma’s pathogenesis and progression.
Shaimaa M Abo-Youssef, Amira H Allam, Mysa S Mustafa, Hasnaa S Abd el Hamid, Amany K Shahat, Hany H Moussa   +5 more
doaj   +1 more source