Results 31 to 40 of about 12,528,653 (292)

Interleukin-5 modulates interleukin-8 secretion in eosinophilic inflammation

Mediators of Inflammation, 1998
Serum and BALF (bronchoalveolar lavage fluid) IL-8 levels and serum levels were investigated in Tox ocara canis infected guinea-pigs and the role of IL-5 as a modulator of cytokine secretion was studied.
L. H. Faccioli, A. I. Medeiros, A. Malheiro, R. C. L. R. Pietro, A. Januário, B. B. Vargaftig   +5 more
doaj   +1 more source

Mepolizumab in the treatment of bronchial asthma in children

Медицинский совет, 2020
Severe bronchial asthma in children remains a serious problem, which is due to the high risk of mortality, side effects of therapy with high doses of glucocorticosteroids, significant consumption of health resources.
Yu. L. Mizernitskiy, I. M. Mel'nikova, V. A. Pavlenko   +2 more
doaj   +1 more source

In vitro generation of interleukin-10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper 1 (Th1)- and Th2-inducing cytokines [PDF]

, 2002
We show that a combination of the immunosuppressive drugs, vitamin D3 and Dexamethasone, induced human and mouse naive CD4(+) T cells to differentiate in vitro into regulatory T cells.
Hawrylowicz, C.M., Robert L. Coffman, André Boonstra, Richards, David F, Richards, D.F., Catherine M. Hawrylowicz, Savelkoul, H.F.J., Savelkoul, HFJ (Huub), Crain, Chad, Anne O'Garra, O' Garra, A, de Waal-Malefyt, R., Coffman, R.L., O'Garra, Anne, Cua, D.J., Chad Crain, Cua, DJ, Huub F. Savelkoul, Coffman, RL, Waal-Malefyt, R., de, Cua, Daniel J, Savelkoul, Huub F, Barrat, Franck J, de Waal-Malefyt, René, de Waal-Malefyt, R, Hawrylowicz, Catherine M; id_orcid, Crain, C., Barrat, FJ, Barrat, F.J., Crain, C, Coffman, Robert L, Boonstra, P.A., Daniel J. Cua, Hawrylowicz, CM, Franck J. Barrat, David F. Richards, O'Garra, A., René de Waal-Malefyt, Richards, DF, Boonstra, Andre   +39 more
core   +1 more source

Interleukin-5 Mediates Parasite-Induced Protection against Experimental Autoimmune Encephalomyelitis: Association with Induction of Antigen-Specific CD4+CD25+ T Regulatory Cells

Frontiers in Immunology, 2017
ObjectiveTo examine if the protective effect of parasite infection on experimental autoimmune encephalomyelitis (EAE) was due to interleukin (IL)-5, a cytokine produced by a type-2 response that induces eosinophilia.
Giang T. Tran, Paul L. Wilcox, Lindsay A. Dent, Catherine M. Robinson, Nicole Carter, Nirupama D. Verma, Bruce M. Hall, Suzanne J. Hodgkinson   +7 more
doaj   +1 more source

Episodic angioedema associated with eosinophilia [PDF]

Anais Brasileiros de Dermatologia, 2017
: We report a 12-year-old girl who presented with recurrent angioedema on the face, trunk, and extremities, and concomitant marked weight gain for 5 years.
Fang Liu, Wenxing Hu, Haibo Liu, Min Zhang, Hong Sang   +4 more
doaj   +1 more source

Short-term stimulation with interleukin (IL)-4 enhances purified protein derivative-induced production of an eosinophil chemotactic lymphokine, but suppresses IL-5 production

Allergology International, 1998
The effect of interleukin (IL)-4 on eosinophil chemotactic lymphokine (ECL) production from peripheral blood mononuclear cells (PBMC) stimulated with purified protein derivative (PPD) was examined.
Takehiko Nishiyama, Taishi Hata, Hiroki Okada, Mitsuomi Hiroshima   +3 more
doaj   +1 more source

Management of Severe Asthma in Eosinophilic Granulomatosis with Polyangiitis with Interleukin-5-Targeted Therapies: Current Status and Report of Two Cases

Applied Sciences, 2022
Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic disorder characterized by peripheral eosinophilia, severe eosinophilic asthma, sinusitis, transient pulmonary infiltrates, and features of medium/small-vessel vasculitis.
Ciro Romano, Domenico Cozzolino, Ausilia Sellitto, Luca Rinaldi   +3 more
doaj   +1 more source

Biological functions and clinical efficacy of IL-5/IL-5Rα-targeted therapies across eosinophilia-associated diseases

Frontiers in Immunology
Interleukin-5 (IL-5) is a central regulator of eosinophil differentiation, maturation, survival, activation, and mobilization, and it contributes to eosinophil recruitment to inflamed tissues.
Johannes Lübke, Andreas Reiter, Juliana Schwaab   +2 more
doaj   +1 more source

Eosinophil Lineage-Committed Progenitors as a Therapeutic Target for Asthma

Cells, 2021
Eosinophilic asthma is the most prevalent phenotype of asthma. Although most asthmatics are adequately controlled by corticosteroid therapy, a subset (5–10%) remain uncontrolled with significant therapy-related side effects. This indicates the need for a
Brittany M. Salter, Xiaotian Ju, Roma Sehmi   +2 more
doaj   +1 more source

Modulation by IL-10 of antigen-induced allergic responses in mice

Memorias do Instituto Oswaldo Cruz, 1997
Over the last few years, we examined the anti-allergic properties of interleukin (IL)-10 in different models of inflammation in the mouse, as well as against IgE-dependent activation of mouse bone marrow-derived mast cells (BMMC).
Claudia Zuany-Amorim, B Boris Vargaftig, Marina Pretolani   +2 more
doaj   +1 more source