Human mid-gestation amniotic fluid contains interleukin-16 bioactivity [PDF]
, 2009 CD4-positive cells are detectable in the human fetal gastrointestinal tract from 11 weeks of gestation. Interleukin-16 (IL-16) is a chemoattractant for CD4(+) cells and, via fetal swallowing of amniotic fluid, could mediate the influx of CD4(+) cells ...
Warner, J. +17 more
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Modulation by IL-10 of antigen-induced allergic responses in mice
Memorias do Instituto Oswaldo Cruz, 1997 Over the last few years, we examined the anti-allergic properties of interleukin (IL)-10 in different models of inflammation in the mouse, as well as against IgE-dependent activation of mouse bone marrow-derived mast cells (BMMC).
Claudia Zuany-Amorim +2 more
doaj +1 more source
The effects of anti-interleukin-5 on SABA rescue use.
, 2016 The effects of anti-interleukin-5 on SABA rescue use.
Ting Liu (45625) +4 more
core +1 more source
In vitro generation of interleukin-10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper 1 (Th1)- and Th2-inducing cytokines [PDF]
, 2002 We show that a combination of the immunosuppressive drugs, vitamin D3 and Dexamethasone, induced human and mouse naive CD4(+) T cells to differentiate in vitro into regulatory T cells.
Hawrylowicz, C.M. +38 more
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Drugs in Context, 2019 Background: Asthma is an inflammatory disease of the airways with symptoms that vary over time and intensity, sometimes leading to disability or even death. Eosinophilic asthma accounts for 25% of cases of severe asthma.
Olalla Montero-Pérez +2 more
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Selective suppression of leukocyte recruitment in allergic inflammation
Memorias do Instituto Oswaldo Cruz, 2005 Allergic diseases result in a considerable socioeconomic burden. The incidence of allergic diseases, notably allergic asthma, has risen to high levels for reasons that are not entirely understood.
CL Weller, PJ Jose, TJ Williams
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Begg’s funnel plot evaluated the effect of anti-interleukin-5 on FEV1.
, 2016 Begg’s funnel plot evaluated the effect of anti-interleukin-5 on FEV1.
Ting Liu (45625) +4 more
core +1 more source
Interleukin 5 as a therapeutic target in severe asthma
Alergologia PolskaAsthma is a chronic inflammatory disease of the airways, the severe forms of which can lead to severe exacerbations and significant deterioration in quality of life.
Hubert Bajer, Rafał Pawliczak
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Covalent modification of the interleukin‐5 receptor by isothiazolones leads to inhibition of the binding of interleukin‐5 [PDF]
European Journal of Biochemistry, 1994 Using a fusion protein of the human interleukin‐5‐receptor α chain (hILSRα) and the human IgG Cγ3 chain (hIL5Rα‐hγ3), we have developed a solid‐phase assay for high‐flux screening of a collection of synthetic compounds. We report on the identification of isothiazolone derivatives as potent inhibitors of binding of interleukin‐5 (IL5) to the hIL5Ra, as ...
R, Devos +7 more
openaire +2 more sources
Eosinophil Activation Status in Separate Compartments and Association with Asthma
Frontiers in Medicine, 2017 Asthma is frequently characterized by eosinophil-rich airway inflammation. Airway eosinophilia is associated with asthma exacerbations and likely plays a part in airway remodeling.
Mats W. Johansson
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