Results 21 to 30 of about 7,367 (214)
Interleukin 5 as a therapeutic target in severe asthma
Alergologia PolskaAsthma is a chronic inflammatory disease of the airways, the severe forms of which can lead to severe exacerbations and significant deterioration in quality of life.
Hubert Bajer, Rafał Pawliczak
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Th2 cytokines and asthma — The role of interleukin-5 in allergic eosinophilic disease
Respiratory Research, 2001 Interleukin-5 is produced by a number of cell types, and is responsible for the maturation and release of eosinophils in the bone marrow. In humans, interleukin-5 is a very selective cytokine as a result of the restricted expression of the interleukin-5 ...
Chapman Richard W +4 more
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Drugs in Context, 2019 Background: Asthma is an inflammatory disease of the airways with symptoms that vary over time and intensity, sometimes leading to disability or even death. Eosinophilic asthma accounts for 25% of cases of severe asthma.
Olalla Montero-Pérez +2 more
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Selective suppression of leukocyte recruitment in allergic inflammation
Memorias do Instituto Oswaldo Cruz, 2005 Allergic diseases result in a considerable socioeconomic burden. The incidence of allergic diseases, notably allergic asthma, has risen to high levels for reasons that are not entirely understood.
CL Weller, PJ Jose, TJ Williams
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Pathogens, 2022 Allergen immunotherapy (AIT), such as subcutaneous immunotherapy (SCIT), is a treatment targeting the causes of allergic diseases. The roles of extracellular vesicles (EVs), bilayer lipid membrane blebs released from all types of cells, in AIT have not ...
Masaya Matsuda +3 more
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Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
Interleukin-5 in the Pathophysiology of Severe Asthma [PDF]
Frontiers in Physiology, 2019 Interleukin-5 (IL-5) exerts a central pathogenic role in differentiation, recruitment, survival, and degranulation of eosinophils. Indeed, during the last years, significant advances have been made in our understanding of the cellular and molecular mechanisms underlying the powerful actions of IL-5 finalized to the induction, maintenance, and ...
Corrado Pelaia +11 more
openaire +3 more sources
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
IL-5 and IL-5 receptor in asthma
Memorias do Instituto Oswaldo Cruz, 1997 Eosinophils, along with mast cells are key cells involved in the innate immune response against parasitic infection whereas the adaptive immune response is largely dependent on lymphocytes. In chronic parasitic disease and in chronic allergic disease, IL-
Kotsimbos ATC, Hamid Q
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Eosinophil Activation Status in Separate Compartments and Association with Asthma
Frontiers in Medicine, 2017 Asthma is frequently characterized by eosinophil-rich airway inflammation. Airway eosinophilia is associated with asthma exacerbations and likely plays a part in airway remodeling.
Mats W. Johansson
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