Results 51 to 60 of about 673,896 (307)
Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers +9 morewiley +1 more sourceB-1 Cell Heterogeneity and the Regulation of Natural and Antigen-Induced IgM Production. [PDF]
, 2016 A small subset of B cells, termed B-1 cells, with developmental origins, phenotypes, and functions that are distinct from those of conventional B cells exist in mice. It contributes the vast majority of spontaneously produced "natural" IgM.Alugupalli, Alugupalli, Ansel, Avrech, Barber, Baumgarth, Baumgarth, Baumgarth, Baumgarth, Ben-Hur, Berland, Boes, Boes, Briles, Cazac, Chace, Chen, Choi, Choi, Cole, Colombo, Cosenza, Cunningham, Dexter, Duber, Ehrenstein, Elvington, Flajnik, Forster, Fung, Gil-Cruz, Godin, Gordon, Ha, Haas, Hardy, Hardy, Hayakawa, Hayakawa, Holodick, Holodick, Holodick, Hooijkaas, Kantor, Kantor, Kawahara, Kearney, Kin, Kobayashi, Kretschmer, Kroese, Kroese, Lalor, Lalor, Lalor, Mercolino, Montecino-Rodriguez, Montecino-Rodriguez, Moon, Morris, Murakami, Nguyen, Nisitani, Ohdan, Okabe, Ouchida, Patel, Perdiguero, Rahyab, Reynolds, Sigal, Stoermann, Tominaga, Tornberg, van der Pol, Vas, Vaux, Waffarn, Wardemann, Watanabe, Yang, Yang, Yoshida, Yoshimoto, Yuan, Zhou +85 morecore +5 more sourcesGlucocorticoids—All-Rounders Tackling the Versatile Players of the Immune System [PDF]
, 2019 Glucocorticoids regulate fundamental processes of the human body and control cellular functions such as cell metabolism, growth, differentiation, and apoptosis.Agarwal, Al-Mousawi, Allen, Almawi, Anderson, Andreae, Annunziato, Anthony, Arya, Avnir, Avnir, Baatjes, Banchereau, Banuelos, Banuelos, Barnes, Beck, Beck, Belvisi, Bengtsson, Benson, Bentley, Berdeli, Blotta, Borish, Brack, Bradding, Braun, Brozek, Burger, Buttgereit, Buttgereit, Buttgereit, Capell, Chan, Chatham, Chen, Choo, Chung, Clutterbuck, Cohn, Corbera-Bellalta, Cosmi, Cosmi, Crocker, Cronstein, Damsker, Dao Nguyen, Daynes, Daynes, de Castro Kroner, Deng, Dolhain, Dorner, Dougherty, Durham, Eichenauer, Eichhorst, Eklund, Erin, Espigol-Frigole, Fanouriakis, Finotto, Firestein, Firestein, Franchimont, Franchimont, Franco, Gao, Geginat, Gemou-Engesaeth, Gladman, Gomes, Gracie, Gregersen, Greiner, Grindebacke, Guiducci, Gupta, Hadji, Hagan, Hahn, Hamid, Hamid, Hanahan, Haneda, Hartl, Hasegawa, Hawrylowicz, Hehlmann, Heidari, Heiman, Hellmich, Hermann-Kunz, Hernandez-Rodriguez, Hicsonmez, Hirahara, Hoelzer, Hollenberg, Hu, Hussain, Hutchison, Inaba, Ismaili, Jacobi, Jacobi, Jee, Jennette, Jiang, Jin, Jing, John, Jones, Jones, Kansal, Kaplan, Karagiannidis, Kirwan, Klarenbeek, Klassen, Kleiman, Klein, Klimek, Kotake, Kotake, Kovalovsky, Kremer, Kruth, Leppert, Li, Li-Weber, Liberman, Liles, Lim, Lin, Linden, Liu, Loetscher, Lohse, Lugar, Luo, Machold, Maggi, Maneechotesuwan, Manzoni, Martinez-Sanchez, Maruotti, Matsui, Matteson, McDonough, Meagher, Mercieca, Merrill, Miller, Miltenburg, Mitra, Miyasaka, Miyaura, Moallem, Morita, Moynihan, Mozo, Muehling, Munck, Muraro, Murphy, Naseer, Neeck, Neeck, Nicholson, O'Byrne, O'Byrne, Oakley, Oakley, Ochiai, Odendahl, Oppong, Ospelt, Parrillo, Patel, Pawankar, Pearson, Perez-Guerrero, Pers, Picchianti-Diamanti, Pratt, Pratt, Pui, Qin, Quinn, Radich, Rainer, Rak, Ramirez, Rank, Ratman, Refojo, Reichardt, Rider, Ring, Robinson, Robinson, Ronnblom, Ruiz-Arruza, Saadoun, Sallusto, Samson, Samson, Santos, Schacke, Schacke, Scherlinger, Schmitz, Schug, Shah, Shaw, Shlomchik, Siegel, Smith, Smolen, Smolen, Song, Stahn, Stahn, Stellato, Stone, Strehl, Strehl, Tanaka, Terrades-Garcia, Theofilopoulos, Thomas, Thomas, Till, Tuckermann, Turjeman, Ulmansky, Umetsu, van der Geest, van Oosterhout, Vandevyver, Verhoef, Verstappen, von Bernus, von Hertzen, Waknine-Grinberg, Walker, Wang, Wassenberg, Watanabe, Wen, Weyand, Weyand, Wheatley, Wikstrom, Willemze, Wills-Karp, Wills-Karp, Wollenberg, Wollenberg, Wright, Wu, Wuthrich, Xystrakis, Yamamoto, Yan, Yang, Ying, Zubiaga +268 morecore +1 more sourceEstablishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns +10 morewiley +1 more sourceIFN-gamma is associated with risk of Schistosoma japonicum infection in China.
, 2003 Before the start of the schistosomiasis transmission season, 129 villagers resident on a Schistosoma japonicum-endemic island in Poyang Lake, Jiangxi Province, 64 of whom were stool-positive for S.Bickle, QD, Chen, SZ, Cousens, SN, Hu, LS, Ji, MJ, Shen, L, Su, C, Taylor, MG, Weir, RE, Wu, GL, Wu, HW, Xie, ZW, Zhang, Y, Zhang, ZS +13 morecore +1 more sourceThe host immune response to gastrointestinal nematode infection in sheep [PDF]
, 2015 non peer reviewedGastrointestinal nematode infection represents a major threat to the health, welfare and productivity of sheep populations worldwide. Infected lambs have a reduced ability to absorb nutrients from the gastrointestinal tract, resulting in Abraham, Ahmed, Akiho, Amarante, Andronicos, Anthony, Balic, Balic, Balic, Balic, Becattini, Beraldi, Bishop, Bisset, Bisset, Bowdridge, Brunsdon, Brunsdon, Brunsdon, Buddle, Cardia, Clarke, Conway, Coop, Craig, Craig, Crespo, Dawicki, Deplancke, deSchoolmeester, Diez-Tascon, Donaldson, Douch, Douch, Dunsmore, Else, Finkelman, Finkelman, Finney, French, Fuhrman, Geijtenbeek, Gilfillan, Gill, Glass, Gossner, Gossner, Grainger, Halliday, Hansen, Harriman, Harrison, Harrison, Hassan, Hassan, Henderson, Hogan, Houdijk, Hsieh, Huntley, Huntley, Huntley, Ingham, Khan, Kim, Kooyman, Korn, Lacroux, Lazarevic, Lighvani, MacKinnon, Madden, Malan, Mantovani, Marson, McClure, McGuckin, McKenna, McRae, McSorley, Meeusen, Mori, Nair, Ohkura, Paul, Pernthaner, Pernthaner, Pettit, Rainbird, Rosenberg, Sangster, Scott, Seaton, Shakya, Shaw, Shaw, Smith, Smith, Stear, Stear, Stear, Stear, Stevenson, Stone, Strain, Sutherland, Szabo, Taylor, Terefe, Urb, Vallance, Vignali, Voehringer, Williams +113 morecore +1 more sourceHippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà +11 morewiley +1 more source
