Results 81 to 90 of about 1,081,549 (346)
Molecular basis of a high affinity murine interleukin-5 receptor. [PDF]
The EMBO Journal, 1991 The mouse interleukin-5 receptor (mIL-5R) consists of two components one of which, the mIL-5R alpha-chain, binds mIL-5 with low affinity. Recently we demonstrated that monoclonal antibodies (Mabs) recognizing the second mIL-5R beta-chain, immunoprecipitate a p130-140 protein doublet which corresponds to the mIL-3R and the mIL-3R-like protein, the ...
R, Devos +6 more
openaire +2 more sources
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
Targeting P2X7 receptor for the treatment of central post-stroke pain in a rodent model
Neurobiology of Disease, 2015 Stroke is a leading cause of death and disability in industrialized countries. Approximately 8–14% of stroke survivors suffer from central post-stroke pain (CPSP) when hemorrhagic stroke occurs in lateral thalamic regions, which severely affects their ...
Yung-Hui Kuan +4 more
doaj +1 more source
Comparison of 5 Different Rat Models to Establish a Standard Animal Model for Research Into Interstitial Cystitis [PDF]
International Neurourology Journal, 2017 Purpose We evaluated 5 different rat models using different agents in order to establish a standard animal model for interstitial cystitis (IC) in terms of the functional and pathologic characteristics of the bladder.
Phil Hyun Song +11 more
doaj +1 more source
Immune and Inflammatory Pathways in Non-Alcoholic Steatohepatitis (NASH). An update [PDF]
, 2019 Non-alcoholic steatohepatitis (NASH), also known as fatty liver disease (FLD), is a major public health problem. It is considered to be the hepatic manifestation of the metabolic syndrome.
Breaban, Iulia +10 more
core +1 more source
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
Cytokine tuning of intestinal epithelial function [PDF]
, 2018 The intestine serves as both our largest single barrier to the external environment and the host of more immune cells than any other location in our bodies.
Andrews, Caroline +2 more
core +4 more sources
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
A murine intestinal intraepithelial NKp46-negative innate lymphoid cell population characterized by group 1 properties [PDF]
, 2017 The Ly49E receptor is preferentially expressed on murine innate-like lymphocytes, such as epidermal V gamma 3 T cells, intestinal intraepithelial CD8 alpha alpha(+) T lymphocytes, and CD49a(+) liver natural killer (NK) cells.
Biswas, Aindrila +15 more
core +2 more sources
Aging and Cancer, EarlyView.This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source