Results 171 to 180 of about 53,904 (214)

Leptin and leptin receptor-related monogenic obesity

Biochimie, 2012
The studies based on candidate genes and encoded proteins known to cause severe obesity in rodents, have shown that these genes also contribute to human early-onset obesity especially for those involved in the leptin pathway: the leptin (LEP) and leptin receptor (LEPR) genes.
Beatrice, Dubern, Karine, Clement
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Role of leptin and leptin receptors in hematological malignancies

Leukemia & Lymphoma, 2015
Leptin is an adipose-derived cytokine that has an important role in bodyweight homeostasis and energy balance. There are a number of studies which have suggested that leptin and its receptors dysregulation play a critical role in the development of malignancies including hematological malignancies, mainly via activation of the JAK/STAT pathway which ...
Shahab, Uddin, Ramzi M, Mohammad
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Leptin and Leptin Receptor in Anterior Pituitary Function

Pituitary, 2001
Leptin is a 16 kDa protein that exerts important effects on the regulation of food intake and energy expenditure by interacting with the leptin receptor in the brain and in many other tissues. Although leptin is produced mainly by white adipose tissue, several laboratories have shown low levels of leptin production by a growing number of tissues ...
R V, Lloyd, L, Jin, I, Tsumanuma, S, Vidal, K, Kovacs, E, Horvath, B W, Scheithauer, M E, Couce, B, Burguera   +8 more
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Leptin, leptin soluble receptor and coronary atherosclerosis

Experimental and Clinical Endocrinology & Diabetes, 2007
AbstractBackground  The adipose tissue‐related hormone leptin plays an important role in the regulation of body weight. The associations of leptin and leptin soluble receptor (sOb‐R) with coronary artery disease (CAD) are not clear.Design  We measured leptin and sOb‐R in 543 consecutive patients (379 men, 164 women) referred for coronary angiography ...
G, Hoefle, C H, Saely, L, Risch, P, Rein, L, Koch, F, Schmid, S, Aczél, T, Marte, P, Langer, H, Drexel   +9 more
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Leptin, Leptin Receptors, and the Control of Body Weight

Nutrition Reviews, 2009
The assimilation, storage, and disposition of nutrient energy constitute a complex homeostatic system central to the survival of both prokaryotic and eukaryotic organisms. In vertebrates, and especially among land dwelling mammalian species, the ability to store large quantities of energy-dense fuel in the form of adipose tissue triglyceride permits ...
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Localization of leptin and leptin receptor in the bovine adenohypophysis

Domestic Animal Endocrinology, 2008
The present study was carried out to detail the cellular localization of leptin (Lep) and the leptin receptor (LepR) in the bovine adenohypophysis. Lep immunoreactivity (Lep-ir) was found in about 30% of adenohypophysial cells in the gland. Immunochemistry of Lep and specific hormones using serial sections revealed that Lep-ir was present in 60.4% of ...
Hideki, Ogasawara, Shyuichi, Ohwada, Yasuhiro, Nagai, Yoshikazu, Taketa, Masatoshi, Matsuzaki, Sachi, Tanaka, Kouichi, Watanabe, Hisashi, Aso, Takahiro, Yamaguchi   +8 more
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Localization of Leptin Binding Domain in the Leptin Receptor

Molecular Pharmacology, 1998
The leptin receptor is a member of the class I cytokine receptor family and is involved in the control of appetite and body weight. The predicted amino acid sequence of the extracellular region of the cloned leptin receptor differs from that of many other cytokine receptors in that it contains two homologous segments representing potential ligand ...
T M, Fong, R R, Huang, M R, Tota, C, Mao, T, Smith, J, Varnerin, V V, Karpitskiy, J E, Krause, L H, Van der Ploeg   +8 more
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Immunoassays for Leptin and Leptin Receptors

2006
Availability of methods for accurate and reproducible quantification of lepth in various biological fluids in humans and in animals has greatly facilitated research leading to the understanding of its role in various physiological and pathophysiological conditions. Immunoassay techniques provide a simple and robust tool for measurement of biomolecules.
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Plasma leptin levels in pigs with different leptin and leptin receptor genotypes

Journal of Animal Breeding and Genetics, 2008
SummaryA C3469T mutation at exon 3 of the pig leptin (Lep) gene has been genotyped in diverse pig breeds yielding controversial results with regard to its association with growth, fatness and carcass traits. A similar situation has been reported for a HpaII restriction fragment length polymorphism (RFLP) in the pig leptin receptor (Lepr) gene, where ...
Amills, Marcel, Villalba, D., Tor, M., Mercadé, Anna, Gallardo, David, Cabrera, Betlem, Jiménez, N., Noguera, José L., Sánchez, Armand, Estany, J.   +9 more
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The involvement of leptin in humans revealed by mutations in leptin and leptin receptor genes

Trends in Pharmacological Sciences, 1999
Support for our work comes mostly from the Centre National de la Recherche Scientifique, the Institut National de la Sante et de la Recherche Medicale, the University of Paris VII, the Ministry for Research and Technology. We are also grateful for help from the Ligue Nationale contre le Cancer, the Fondation pour la Recherche Medicale Francaise and ...
A D, Strosberg, T, Issad
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