Results 271 to 280 of about 94,971 (311)

Leptin Receptor and Leukemia

Leukemia & Lymphoma, 2000
The receptor for leptin, the gene product of the obese gene, is expressed in hematopoietic stem cells. Leptin stimulates normal myeloid and erythroid development, and is secreted from bone marrow adipocytes, which occupy most of the marrow cavity in humans.
M, Hino, T, Nakao, T, Yamane, K, Ohta, T, Takubo, N, Tatsumi   +5 more
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Leptin, leptin soluble receptor and coronary atherosclerosis

Experimental and Clinical Endocrinology & Diabetes, 2007
AbstractBackground  The adipose tissue‐related hormone leptin plays an important role in the regulation of body weight. The associations of leptin and leptin soluble receptor (sOb‐R) with coronary artery disease (CAD) are not clear.Design  We measured leptin and sOb‐R in 543 consecutive patients (379 men, 164 women) referred for coronary angiography ...
G, Hoefle, C H, Saely, L, Risch, P, Rein, L, Koch, F, Schmid, S, Aczél, T, Marte, P, Langer, H, Drexel   +9 more
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Leptin and Leptin Receptor in Anterior Pituitary Function

Pituitary, 2001
Leptin is a 16 kDa protein that exerts important effects on the regulation of food intake and energy expenditure by interacting with the leptin receptor in the brain and in many other tissues. Although leptin is produced mainly by white adipose tissue, several laboratories have shown low levels of leptin production by a growing number of tissues ...
R V, Lloyd, L, Jin, I, Tsumanuma, S, Vidal, K, Kovacs, E, Horvath, B W, Scheithauer, M E, Couce, B, Burguera   +8 more
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Homology Modeling of Human Leptin/ Leptin Receptor Complex

Biochemical and Biophysical Research Communications, 2000
Leptin receptor mediates the weight regulatory signal carried by the adipocyte-secreted peptide hormone, leptin. It is important to understand the atomic interactions between leptin and the receptor for the therapeutic applications. However, the structure of leptin receptor has not yet been determined. Leptin shows structural similarity to G-CSF, while
T, Hiroike, J, Higo, H, Jingami, H, Toh
openaire   +2 more sources

Human mast cells express leptin and leptin receptors

Histochemistry and Cell Biology, 2009
Mast cells are immune cells that produce and secrete a variety of mediators and cytokines that influence various inflammatory and immune processes. Leptin is a cytokine regulating metabolic, endocrine as well as immune functions via the leptin receptor which is expressed by many immune cells.
Taildeman, Jasmien, Perez-Novo, Claudina A., Rottiers, Isabelle, Ferdinande, Liesbeth, Waeytens, Anouk, De Colvenaer, Veerle, Bachert, Claus, Demetter, Pieter, Waelput, Wim, Braet, Katleen, Cuvelier, Claude A.   +10 more
openaire   +4 more sources

[Leptin Receptor].

Nihon rinsho. Japanese journal of clinical medicine, 1998
Leptin is a fat cell-derived satiety factor that regulates food intake and energy expenditure. Its effects are mediated by interactions with the leptin receptor (Ob-R) that is alternatively spliced to encode at least five isoforms(a-e), which are distributed in a wide range of tissues including the hypothalamus.
K, Takaya, Y, Ogawa, H, Masuzaki, N, Matsuoka, K, Hosoda, K, Nakao   +5 more
openaire   +1 more source

Serum leptin levels, skin leptin and leptin receptor expression in psoriasis

British Journal of Dermatology, 2008
Recent studies support the relation of psoriasis with obesity and cardiovascular disease. Leptin, a peptide hormone secreted predominantly from adipose tissue, is involved in the regulation of energy intake and expenditure. Recently, it has been shown to have several immunological effects including induction of proinflammatory cytokine production.To ...
A A, Cerman, S, Bozkurt, A, Sav, A, Tulunay, M O, Elbaşi, T, Ergun   +5 more
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Expression of Placental Leptin and Leptin Receptors in Preeclampsia

International Journal of Gynecological Pathology, 2004
This study investigated the expression profile of placental leptin and leptin receptor isoforms in preeclampsia, using placental tissue from normal pregnancies that were matched in gestational age and birth weight as controls. A total of 29 cases of preeclampsia were studied by immunohistochemistry, including 16 severe and 13 mild preeclampsia cases ...
Li, RHW, Poon, SCS, Yu, MY, Wong, YF
openaire   +4 more sources

Soluble receptor inhibits leptin transport

Journal of Cellular Physiology, 2007
AbstractEvidence both from mice and cultured cells suggests an important role of soluble leptin receptors in obesity and leptin signaling. However, the direct effects of soluble receptors on leptin uptake by cells are not clear. This study shows that soluble leptin receptors antagonize the permeation of leptin across the mouse blood‐brain barrier by ...
Hong, Tu, Abba J, Kastin, Hung, Hsuchou, Weihong, Pan   +3 more
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Immunoassays for Leptin and Leptin Receptors

2006
Availability of methods for accurate and reproducible quantification of lepth in various biological fluids in humans and in animals has greatly facilitated research leading to the understanding of its role in various physiological and pathophysiological conditions. Immunoassay techniques provide a simple and robust tool for measurement of biomolecules.
openaire   +1 more source