Results 261 to 270 of about 720,642 (282)

Molecular mechanism of LH/CG receptor activation

Molecular and Cellular Endocrinology, 1996
It is known that the N-terminal half of the LH/CG receptor is responsible for high hCG binding whereas the C-terminal half is capable of receptor activation. Our results suggest that initial hCG binding at the high affinity site in the N-half receptor induces conformational adjustments.
K S, Ryu, I, Ji, L, Chang, T H, Ji
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Characteristics of Soluble Gonadotropin Receptors for LH and hCG

1974
In order initiate studies on the molecular properties of the gonadotropin receptor sites for luteinizing hormone, subcellular fractions of testis and ovarian homogenates with specific binding affinity for LH and hCG have been treated with non-ionic deter­gents such as ‘Triton X-100’ and ‘Lubrol’ to obtain “solubilized” receptor preparations which are ...
M L, Dufau, E, Charreau, D, Ryan, K J, Catt   +3 more
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Distinct Mechanisms of cAMP Induction by Constitutively Activating LH Receptor and Wild-Type LH Receptor Activated by hCG

Endocrine, 2004
Asp578Gly is the major mutation of luteinizing hormone (LH) receptors in humans. It is a dominant mutant, constitutively activates Galphas, and induces cAMP production in the absence of the cognate hormone, causing the familial male precocious puberty. The mechanism of the elevated basal cAMP level is unclear.
ChangWoo, Lee, Inhae, Ji, Tae H, Ji
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LH and FSH Receptor Mutations and Their Effects on Puberty

Hormone Research in Paediatrics, 2002
Several mutations have been detected in the genes encoding the gonadotrophin receptors, and their phenotypic effects are observed in sexual differentiation, pubertal development and fertility of the affected individuals. Both activating and inactivating mutations are known for the gonadotrophin receptors.
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Increased number of GABAB receptors in the lethargic (lh/lh) mouse model of absence epilepsy

Brain Research, 1993
This study begins to explore possible mechanisms underlying the role of GABAB receptors in absence seizures in lethargic (lh/lh) mice. To test the hypothesis that alterations intrinsic to the GABAB receptor underlie enhanced synaptic activation of these receptors in absence seizures, we measured GABA-displaceable [3H]baclofen binding to neocortical ...
F H, Lin, Z, Cao, D A, Hosford
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Regulation of the LH/CG Receptor by Gonadotropins

1992
The induction of the lutropin/choriogonadotropin receptor (LH/CG-R) by follicle-stimulating hormone (FSH) is one of the hallmarks of the differentiating granulosa cell (GC) (1–3). The mechanisms underlying the induction and regulation of the LH/CG-R, however, are for the most part not well understood.
Deborah L. Segaloff, JoAnne S. Richards, Mario Ascoli, Haiyun Wang   +3 more
openaire   +1 more source

[LH receptors: follicle and endometrium].

Journal de gynecologie, obstetrique et biologie de la reproduction, 2002
LH-receptors are widely distributed in the human body. The talk focussed on ovarian and endometrial receptors. Ovarian LH receptors Uterine LH receptors In conclusion, LH and hCG should no longer be viewed as only gonadal regulating hormones. They have multiple targets in the body.
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Structural features of the LH/CG receptor

Acta Endocrinologica, 1990
M K, Metsikkö, U E, Petäjä-Repo, J T, Lakkakorpi, H J, Rajaniemi   +3 more
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[LH receptors. A new family of G-protein receptors].

Annales d'endocrinologie, 1995
Monoclonal antibodies have been raised against porcine LH receptor and allowed to clone the corresponding messenger RNA from testicular cells. The structure of the LH receptor have been determined. It shows similarities but also differences to other G protein coupled receptors.
M, Misrahi, M T, Vu Hai, G, Meduri, H, Loosfelt, M, Atger, B, Gross, A, Jolivet, E, Milgrom   +7 more
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Fish FSH receptors bind LH

General and Comparative Endocrinology, 2005
In mammals, the interactions between glycoprotein hormones and their cognate receptors are highly specific; unintended cross-reactivity under normal physiological conditions has not been observed. The interactions between fish gonadotropins and their receptors, on the other hand, appeared to be less discriminatory.
Bogerd, Jan, Granneman, Joke C M, Schulz, Rüdiger W, Vischer, Henry F   +3 more
openaire   +1 more source