Results 261 to 270 of about 49,123 (292)
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Biochemical Pharmacology, 1990
Methods previously published by us [Wimalasena et al., J Biol Chem 260: 10689-10697, 1985; Wimalasena et al., J Biol Chem 261: 9416-9420, 1986] were utilized to solubilize the human corpus luteal leuteinizing hormone/human chorionic gonadotropin (LH/hCG) receptor with 3-[(3-cholamide-propyl)dimethylammonio]-1-propanesulfonate (CHAPS) and to purify the ...
K, Alpaugh +4 more
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Methods previously published by us [Wimalasena et al., J Biol Chem 260: 10689-10697, 1985; Wimalasena et al., J Biol Chem 261: 9416-9420, 1986] were utilized to solubilize the human corpus luteal leuteinizing hormone/human chorionic gonadotropin (LH/hCG) receptor with 3-[(3-cholamide-propyl)dimethylammonio]-1-propanesulfonate (CHAPS) and to purify the ...
K, Alpaugh +4 more
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2019
This chapter focuses on the Lutropin (LH)/human chorionic gonadotropin (hCG) receptor itself and largely ignore events subsequent to the binding reaction. Evidence for the existence of gonadotropin receptors began to accumulate in 1940 when S. M. Seidlin noted that a crude gonadotropin preparation lost biological activity when mixed with a mince of hog
Patrick C. Roche, Robert J. Ryan
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This chapter focuses on the Lutropin (LH)/human chorionic gonadotropin (hCG) receptor itself and largely ignore events subsequent to the binding reaction. Evidence for the existence of gonadotropin receptors began to accumulate in 1940 when S. M. Seidlin noted that a crude gonadotropin preparation lost biological activity when mixed with a mince of hog
Patrick C. Roche, Robert J. Ryan
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Targeted disruption of LH receptor gene revealed the importance of uterine LH signaling
Molecular and Cellular Endocrinology, 2005Numerous previous studies have demonstrated that LH and hCG can directly regulate several uterine functions. We investigated in the present study, whether uterine phenotype in LH receptor knockout animals resulted also from the absence of direct actions of LH in the uterus.
D X, Lin, Z M, Lei, X, Li, Ch V, Rao
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Inhibition of Synthesis of Luteinizing Hormone (LH) Receptors by a Down-Regulating Dose of LH*
Endocrinology, 1984Although LH is known to cause down-regulation of the LH/human CG (hCG) receptor, the mechanisms underlying this process are not well understood. Here we have analyzed the effects of LH on the turnover of LH receptors in cultured granulosa cells. Down-regulation was stimulated in FSH-primed granulosa cells by exposure to LH for 1 h.
R H, Schwall, G F, Erickson
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Labeling of LH/hCG receptor in rat ovaries
Biochemical and Biophysical Research Communications, 1975An approach to label the luteinizing hormone/human chorionic gonadotropin (LH/hCG) receptor in ovaries from hCG-primed and superovulated immature rats is described. When ovaries from saline- and hCG-treated animals were incubated in vitro with N-acetyl-l-carbon-14 D-glucosamine and tritiated leucine a marked increase in the incorporation of carbon-14 ...
M R, Pandian, O P, Bahl, S J, Segal
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Studies on the mechanism of LH receptor control by FSH
Molecular and Cellular Endocrinology, 1982Abstract The mechanism of the control of LH/hCG receptor by FSH was investigated using granulosa cells from the immature hypophysectomized estrogen primed rat as a model. The specific binding of [ 125 I]hCG to freshly collected granulosa cells was low (0.18 ± 0.01 fmoles/10 6 cells). By contrast, a marked increase in [ 125 I]hCG binding was observed
G F, Erickson +4 more
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Interactions of LH and hCG with Testicular Gonadotropin Receptors
1973Gonadal receptor sites for LH and hCG were originally demonstrated by morphological studies which employed a variety of labeled hormone preparations to show trophic hormone localization in cells concerned with steroid synthesis and secretion (1–4). Uptake of LH by the Leydig cells of the rat testis has been demonstrated in vivo (3), and in vitro with ...
K J, Catt, M L, Dufau
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Genetic Variation in Testicular LH Receptors in the Mouse
Endocrine Research Communications, 1982The concentration of testicular hCG (LH) binding sites was measured in five mutants with defective endocrine and/or reproductive functions, in a hypoandrogenic inbred strain and in six normal strains. A decrease in hCG binding was found in dw/dw mice, and an increase in Tfm/y and C57Bl10/J mice.
Amador, A, Bartke, A, Beamer, W G
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Purification of LH/hCG Receptor
1990Lutropin (LH) and human choriogonadotropin (hCG) bind to a common specific receptor on the ovarian and testicular plasma membranes (Catt et. al, 1976). The availability of the purified receptor and a knowledge of its size and the number of subunits is essential before any structural characterization can be undertaken.
Om P. Bahl, Hakimuddin T. Sojar
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Molecular mechanism of LH/CG receptor activation
Molecular and Cellular Endocrinology, 1996It is known that the N-terminal half of the LH/CG receptor is responsible for high hCG binding whereas the C-terminal half is capable of receptor activation. Our results suggest that initial hCG binding at the high affinity site in the N-half receptor induces conformational adjustments.
K S, Ryu, I, Ji, L, Chang, T H, Ji
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